White matter mapping in Alzheimer's disease: A neuropathological study.
Sjöbeck, Martin LU ; Haglund, Mattias LU and Englund, Elisabet LU
(2006)
In Neurobiology of Aging
27(5).
p.673-680
- Abstract
- White matter disease (WMD) with pervasive non-focal subtotal tissue loss is frequently seen in Alzheimer's disease (AD) upon neuropatholooical examination. Although WMD has varying effects on AD symptoms, accurate clinical detection is difficult due partly to scarcity of correlative structural imaging and histopathological studies. Neuropathological Studies of WMD severity and distribution have been conducted earlier using semi-quantitative methods. A technique for quantifying WMD objectively in large white matter areas, based on optical density (OD) measurements oil images of scanned whole-brain sections, was developed and was validated using conventional microscopic assessment. Altogether, 16 AD cases with concomitant WMD (AD-WMD) and 9... (More)
- White matter disease (WMD) with pervasive non-focal subtotal tissue loss is frequently seen in Alzheimer's disease (AD) upon neuropatholooical examination. Although WMD has varying effects on AD symptoms, accurate clinical detection is difficult due partly to scarcity of correlative structural imaging and histopathological studies. Neuropathological Studies of WMD severity and distribution have been conducted earlier using semi-quantitative methods. A technique for quantifying WMD objectively in large white matter areas, based on optical density (OD) measurements oil images of scanned whole-brain sections, was developed and was validated using conventional microscopic assessment. Altogether, 16 AD cases with concomitant WMD (AD-WMD) and 9 cases of AD without WMD (AD-only) were analysed. The OD values correlated significantly with the neuropathological severity of WMD and were significantly lower in AD-WMD than ill AD-only in frontal, frontoparietal, temporal and parietal white matter but not ill the occipital white matter, the frontal OD difference being greatest. Useful baseline information oil WMD distribution in AD to relate to in vivo imaging results was obtained. (c) 2005 Published by Elsevier Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/138000
- author
- Sjöbeck, Martin
LU
; Haglund, Mattias
LU
and Englund, Elisabet
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer's disease, optical density, white matter disease, dementia
- in
- Neurobiology of Aging
- volume
- 27
- issue
- 5
- pages
- 673 - 680
- publisher
- Elsevier
- external identifiers
-
- pmid:15894407
- wos:000237177200003
- scopus:33645958247
- pmid:15894407
- ISSN
- 1558-1497
- DOI
- 10.1016/j.neurobiolaging.2005.03.007
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Pathology, (Lund) (013030000)
- id
- d8aa6566-c9b5-4477-8b9d-f77c6da39893 (old id 138000)
- date added to LUP
- 2016-04-01 12:19:02
- date last changed
- 2022-01-27 01:56:14
@article{d8aa6566-c9b5-4477-8b9d-f77c6da39893,
abstract = {{White matter disease (WMD) with pervasive non-focal subtotal tissue loss is frequently seen in Alzheimer's disease (AD) upon neuropatholooical examination. Although WMD has varying effects on AD symptoms, accurate clinical detection is difficult due partly to scarcity of correlative structural imaging and histopathological studies. Neuropathological Studies of WMD severity and distribution have been conducted earlier using semi-quantitative methods. A technique for quantifying WMD objectively in large white matter areas, based on optical density (OD) measurements oil images of scanned whole-brain sections, was developed and was validated using conventional microscopic assessment. Altogether, 16 AD cases with concomitant WMD (AD-WMD) and 9 cases of AD without WMD (AD-only) were analysed. The OD values correlated significantly with the neuropathological severity of WMD and were significantly lower in AD-WMD than ill AD-only in frontal, frontoparietal, temporal and parietal white matter but not ill the occipital white matter, the frontal OD difference being greatest. Useful baseline information oil WMD distribution in AD to relate to in vivo imaging results was obtained. (c) 2005 Published by Elsevier Inc.}},
author = {{Sjöbeck, Martin and Haglund, Mattias and Englund, Elisabet}},
issn = {{1558-1497}},
keywords = {{Alzheimer's disease; optical density; white matter disease; dementia}},
language = {{eng}},
number = {{5}},
pages = {{673--680}},
publisher = {{Elsevier}},
series = {{Neurobiology of Aging}},
title = {{White matter mapping in Alzheimer's disease: A neuropathological study.}},
url = {{http://dx.doi.org/10.1016/j.neurobiolaging.2005.03.007}},
doi = {{10.1016/j.neurobiolaging.2005.03.007}},
volume = {{27}},
year = {{2006}},
}