Qualify of life and palliation predict survival in patients with chronic alveolar hypoventilation and nocturnal ventilatory support
(2009) In Quality of Life Research 18(3). p.273-280- Abstract
- Non-invasive positive pressure ventilation (NPPV) improves health-related quality of life (HRQL) in patients with chronic alveolar hypoventilation (CAH). We studied the prognostic impact of HRQL on survival in relation to clinical factors. Forty-four patients with CAH due to post-polio (12), scoliosis (11), post-tb (17) or other diagnoses (4) who received nocturnal NPPV were prospectively studied during 6-10 years. Blood gases and HRQL were analysed at baseline and after 9 months and after 8 years. HRQL was evaluated with measures of functioning (SIP), emotional well-being (HADS and MACL), and global QL. Blood gases and HRQL measures improved during NPPV. The overall 5-year survival rate was 73%. In multivariate survival analysis, a... (More)
- Non-invasive positive pressure ventilation (NPPV) improves health-related quality of life (HRQL) in patients with chronic alveolar hypoventilation (CAH). We studied the prognostic impact of HRQL on survival in relation to clinical factors. Forty-four patients with CAH due to post-polio (12), scoliosis (11), post-tb (17) or other diagnoses (4) who received nocturnal NPPV were prospectively studied during 6-10 years. Blood gases and HRQL were analysed at baseline and after 9 months and after 8 years. HRQL was evaluated with measures of functioning (SIP), emotional well-being (HADS and MACL), and global QL. Blood gases and HRQL measures improved during NPPV. The overall 5-year survival rate was 73%. In multivariate survival analysis, a diagnosis of post-polio and low baseline SIP physical index scores, indicating low levels of physical dysfunction, predicted longer survival (P = 0.02, respectively). Similarly, palliation of physical dysfunction and preserved or improved global QL by 9 months were associated with longer overall survival (P = 0.009 and P = 0.001, respectively; multivariate Cox regression). Seventy-three percent of patients treated for CAH with NPPV survived more than 5 years. Diagnosis and self-rated physical functioning at pre-treatment were related to survival, as were major improvements in physical functioning and global QL during NPPV. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1401694
- author
- Olofson, Jan ; Dellborg, Catharina ; Sullivan, Marianne ; Midgren, Bengt LU ; Caro, Oscar and Bergman, Bengt
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Non-invasive, Neuromuscular disorders, Restrictive chest wall disorders, positive pressure ventilation
- in
- Quality of Life Research
- volume
- 18
- issue
- 3
- pages
- 273 - 280
- publisher
- Springer
- external identifiers
-
- wos:000264266400001
- scopus:62349096239
- ISSN
- 1573-2649
- DOI
- 10.1007/s11136-009-9445-7
- language
- English
- LU publication?
- yes
- id
- 3bc11f03-24d8-47fc-bd12-f27f44b167cf (old id 1401694)
- date added to LUP
- 2016-04-01 13:09:40
- date last changed
- 2022-01-27 17:39:52
@article{3bc11f03-24d8-47fc-bd12-f27f44b167cf, abstract = {{Non-invasive positive pressure ventilation (NPPV) improves health-related quality of life (HRQL) in patients with chronic alveolar hypoventilation (CAH). We studied the prognostic impact of HRQL on survival in relation to clinical factors. Forty-four patients with CAH due to post-polio (12), scoliosis (11), post-tb (17) or other diagnoses (4) who received nocturnal NPPV were prospectively studied during 6-10 years. Blood gases and HRQL were analysed at baseline and after 9 months and after 8 years. HRQL was evaluated with measures of functioning (SIP), emotional well-being (HADS and MACL), and global QL. Blood gases and HRQL measures improved during NPPV. The overall 5-year survival rate was 73%. In multivariate survival analysis, a diagnosis of post-polio and low baseline SIP physical index scores, indicating low levels of physical dysfunction, predicted longer survival (P = 0.02, respectively). Similarly, palliation of physical dysfunction and preserved or improved global QL by 9 months were associated with longer overall survival (P = 0.009 and P = 0.001, respectively; multivariate Cox regression). Seventy-three percent of patients treated for CAH with NPPV survived more than 5 years. Diagnosis and self-rated physical functioning at pre-treatment were related to survival, as were major improvements in physical functioning and global QL during NPPV.}}, author = {{Olofson, Jan and Dellborg, Catharina and Sullivan, Marianne and Midgren, Bengt and Caro, Oscar and Bergman, Bengt}}, issn = {{1573-2649}}, keywords = {{Non-invasive; Neuromuscular disorders; Restrictive chest wall disorders; positive pressure ventilation}}, language = {{eng}}, number = {{3}}, pages = {{273--280}}, publisher = {{Springer}}, series = {{Quality of Life Research}}, title = {{Qualify of life and palliation predict survival in patients with chronic alveolar hypoventilation and nocturnal ventilatory support}}, url = {{http://dx.doi.org/10.1007/s11136-009-9445-7}}, doi = {{10.1007/s11136-009-9445-7}}, volume = {{18}}, year = {{2009}}, }