Diffusion and perfusion MRI in patients with ruptured and unruptured intracranial aneurysms treated by endovascular coiling: complications, procedural results, MR findings and clinical outcome.

Cronqvist, Mats; Wirestam, Ronnie; Ramgren, B; Brandt, Lennart; Nilsson, Ola; Säveland, Hans; Holtås, Stig; Larsson, Elna-Marie

Diffusion and perfusion MRI in patients with ruptured and unruptured intracranial aneurysms treated by endovascular coiling: complications, procedural results, MR findings and clinical outcome.

Mark

Cronqvist, Mats ^LU ; Wirestam, Ronnie ^LU

; Ramgren, B ; Brandt, Lennart ^LU ; Nilsson, Ola ^LU ; Säveland, Hans ^LU ; Holtås, Stig ^LU and Larsson, Elna-Marie ^LU (2005) In Neuroradiology 47(11). p.855-873

Abstract: Our purpose was to evaluate treatment safety as well as complications frequency and management in endovascular coiling of intracerebral aneurysms using MR diffusion and perfusion imaging. In this prospective study, 77 MR examinations were performed in conjunction with 43 procedures in 40 patients, 14 patients presented with ruptured and 26 with unruptured aneurysms. Mean time interval between treatment and post-procedure MRI was 29 and 25 h for the ruptured and unruptured aneurysm group, respectively. Peri-procedural complications, including five major events and five minor transient events, occurred in 10/43 procedures (23%), necessitating thrombolytic therapy in two patients and angioplasty in one, all three within the unruptured... (More); Our purpose was to evaluate treatment safety as well as complications frequency and management in endovascular coiling of intracerebral aneurysms using MR diffusion and perfusion imaging. In this prospective study, 77 MR examinations were performed in conjunction with 43 procedures in 40 patients, 14 patients presented with ruptured and 26 with unruptured aneurysms. Mean time interval between treatment and post-procedure MRI was 29 and 25 h for the ruptured and unruptured aneurysm group, respectively. Peri-procedural complications, including five major events and five minor transient events, occurred in 10/43 procedures (23%), necessitating thrombolytic therapy in two patients and angioplasty in one, all three within the unruptured aneurysm group. Fifty-one new lesions were found on post-treatment DWI and 47 of them were regarded as of ischemic origin. Most lesions were small (< 3 mm), ipsilateral to the treated aneurysm and asymptomatic (37/40 patients). Sixty-seven percent of the lesions were found in the ruptured and 33% in the unruptured aneurysm group. The ischemic lesions did occur more frequently in patients treated for aneurysm of large neck size and according to the remodelling technique. The overall morbidity and mortality rates were 14.6 and 7.3% whereas morbidity and mortality rates related to the technique were only 2.6 and 0%, respectively. Silent embolism seems to be more common than clinically evident and partially related to patient presentation, heparinazation and treatment strategy. The capability to depict early complications and analyse their potential causes by using MR with DWI has been of great importance in our modification and improvement of therapeutic protocols, evaluations and strategies. (Less)

Please use this url to cite or link to this publication: https://lup.lub.lu.se/record/144550

author

Cronqvist, Mats ^LU ; Wirestam, Ronnie ^LU

; Ramgren, B ; Brandt, Lennart ^LU ; Nilsson, Ola ^LU ; Säveland, Hans ^LU ; Holtås, Stig ^LU and Larsson, Elna-Marie ^LU

organization

publishing date

2005

type

Contribution to journal

publication status

published

subject

keywords

imaging, intracranial aneurysm, endovascular treatment, magnetic resonance

in

Neuroradiology

volume

47

issue

11

pages

855 - 873

publisher

Springer

external identifiers

wos:000233247700009
pmid:16235046
scopus:28044431830

ISSN

1432-1920

DOI

10.1007/s00234-005-1408-2

language

English

LU publication?

yes

id

6fd0129a-cf52-42e2-9c7d-120eec5177dd (old id 144550)

alternative location

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16235046&dopt=Abstract

date added to LUP

2016-04-01 12:00:50

date last changed

2022-02-03 08:19:30

@article{6fd0129a-cf52-42e2-9c7d-120eec5177dd,
  abstract     = {{Our purpose was to evaluate treatment safety as well as complications frequency and management in endovascular coiling of intracerebral aneurysms using MR diffusion and perfusion imaging. In this prospective study, 77 MR examinations were performed in conjunction with 43 procedures in 40 patients, 14 patients presented with ruptured and 26 with unruptured aneurysms. Mean time interval between treatment and post-procedure MRI was 29 and 25 h for the ruptured and unruptured aneurysm group, respectively. Peri-procedural complications, including five major events and five minor transient events, occurred in 10/43 procedures (23%), necessitating thrombolytic therapy in two patients and angioplasty in one, all three within the unruptured aneurysm group. Fifty-one new lesions were found on post-treatment DWI and 47 of them were regarded as of ischemic origin. Most lesions were small (&lt; 3 mm), ipsilateral to the treated aneurysm and asymptomatic (37/40 patients). Sixty-seven percent of the lesions were found in the ruptured and 33% in the unruptured aneurysm group. The ischemic lesions did occur more frequently in patients treated for aneurysm of large neck size and according to the remodelling technique. The overall morbidity and mortality rates were 14.6 and 7.3% whereas morbidity and mortality rates related to the technique were only 2.6 and 0%, respectively. Silent embolism seems to be more common than clinically evident and partially related to patient presentation, heparinazation and treatment strategy. The capability to depict early complications and analyse their potential causes by using MR with DWI has been of great importance in our modification and improvement of therapeutic protocols, evaluations and strategies.}},
  author       = {{Cronqvist, Mats and Wirestam, Ronnie and Ramgren, B and Brandt, Lennart and Nilsson, Ola and Säveland, Hans and Holtås, Stig and Larsson, Elna-Marie}},
  issn         = {{1432-1920}},
  keywords     = {{imaging; intracranial aneurysm; endovascular treatment; magnetic resonance}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{855--873}},
  publisher    = {{Springer}},
  series       = {{Neuroradiology}},
  title        = {{Diffusion and perfusion MRI in patients with ruptured and unruptured intracranial aneurysms treated by endovascular coiling: complications, procedural results, MR findings and clinical outcome.}},
  url          = {{http://dx.doi.org/10.1007/s00234-005-1408-2}},
  doi          = {{10.1007/s00234-005-1408-2}},
  volume       = {{47}},
  year         = {{2005}},
}

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Diffusion and perfusion MRI in patients with ruptured and unruptured intracranial aneurysms treated by endovascular coiling: complications, procedural results, MR findings and clinical outcome.