Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome.
Fava, Cristiano LU ; Montagnana, Martina LU ; Guerriero, Massimo ; Almgren, Peter LU ; von Wowern, Fredrik ; Minuz, Pietro and Melander, Olle LU
(2009)
In Journal of Hypertension
27.
p.1794-1803
- Abstract
- OBJECTIVE: To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits. METHODS: We conducted fine mapping of the hypertension-linked region on chromosome 2 spanning between 107 and 130 cM using 11 informative polymorphic markers in 260 healthy white siblings belonging to 118 nuclear families. Variance-component linkage analysis was performed for each MetS component and a composite sum of MetS phenotypes as quantitative trait after adjustment for significant covariates using 'Solar software package'.... (More)
- OBJECTIVE: To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits. METHODS: We conducted fine mapping of the hypertension-linked region on chromosome 2 spanning between 107 and 130 cM using 11 informative polymorphic markers in 260 healthy white siblings belonging to 118 nuclear families. Variance-component linkage analysis was performed for each MetS component and a composite sum of MetS phenotypes as quantitative trait after adjustment for significant covariates using 'Solar software package'. Successively, the I/D polymorphism of the ADRA2B gene was genotyped in 5283 patients in the Malmö Diet and Cancer-cardiovascular arm, seeking for association with the MetS using standard definitions and separately, with its individual components. RESULTS: For 24-h pulse pressure and waist/hip ratio, LOD [logarithm of the odds (to the base 10)] scores of more than two were found between 107 and 122 cM on chromosome 2. For the composite sum of MetS phenotypes, LOD score of more than 1 was found between 116 and 120 cM. There was no difference between carriers and noncarriers of the D-allele of the ADRA2B gene in MetS prevalence but D-carriers were associated with significantly higher levels of diastolic blood pressure. CONCLUSION: Our results suggest that chromosome 2 could harbor one or more genes implied in blood pressure homeostasis and MetS development. The ADRA2B I/D polymorphism is not consistently associated with MetS and metabolic/anthropometric parameters but with diastolic blood pressure in an urban-based population of middle-aged Swedes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1453150
- author
- Fava, Cristiano
LU
; Montagnana, Martina
LU
; Guerriero, Massimo
; Almgren, Peter
LU
; von Wowern, Fredrik
; Minuz, Pietro
and Melander, Olle
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Hypertension
- volume
- 27
- pages
- 1794 - 1803
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000269549500012
- pmid:19593211
- scopus:73249130357
- ISSN
- 1473-5598
- DOI
- 10.1097/HJH.0b013e32832d3f9c
- language
- English
- LU publication?
- yes
- id
- 1d058ef1-dc5e-41f3-81e5-aca334d55f62 (old id 1453150)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19593211?dopt=Abstract
- date added to LUP
- 2016-04-04 09:06:50
- date last changed
- 2024-03-13 10:48:31
@article{1d058ef1-dc5e-41f3-81e5-aca334d55f62,
abstract = {{OBJECTIVE: To test whether a previously hypertension-linked 23 cM region on chromosome 2 is linked to the metabolic syndrome (MetS) or its individual components, and whether a common I/D polymorphism of the adrenergic receptor 2b (ADRA2B) gene, mapping in that region, is associated with the same traits. METHODS: We conducted fine mapping of the hypertension-linked region on chromosome 2 spanning between 107 and 130 cM using 11 informative polymorphic markers in 260 healthy white siblings belonging to 118 nuclear families. Variance-component linkage analysis was performed for each MetS component and a composite sum of MetS phenotypes as quantitative trait after adjustment for significant covariates using 'Solar software package'. Successively, the I/D polymorphism of the ADRA2B gene was genotyped in 5283 patients in the Malmö Diet and Cancer-cardiovascular arm, seeking for association with the MetS using standard definitions and separately, with its individual components. RESULTS: For 24-h pulse pressure and waist/hip ratio, LOD [logarithm of the odds (to the base 10)] scores of more than two were found between 107 and 122 cM on chromosome 2. For the composite sum of MetS phenotypes, LOD score of more than 1 was found between 116 and 120 cM. There was no difference between carriers and noncarriers of the D-allele of the ADRA2B gene in MetS prevalence but D-carriers were associated with significantly higher levels of diastolic blood pressure. CONCLUSION: Our results suggest that chromosome 2 could harbor one or more genes implied in blood pressure homeostasis and MetS development. The ADRA2B I/D polymorphism is not consistently associated with MetS and metabolic/anthropometric parameters but with diastolic blood pressure in an urban-based population of middle-aged Swedes.}},
author = {{Fava, Cristiano and Montagnana, Martina and Guerriero, Massimo and Almgren, Peter and von Wowern, Fredrik and Minuz, Pietro and Melander, Olle}},
issn = {{1473-5598}},
language = {{eng}},
pages = {{1794--1803}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Hypertension}},
title = {{Chromosome 2q12, the ADRA2B I/D polymorphism and metabolic syndrome.}},
url = {{http://dx.doi.org/10.1097/HJH.0b013e32832d3f9c}},
doi = {{10.1097/HJH.0b013e32832d3f9c}},
volume = {{27}},
year = {{2009}},
}