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The Escherichia coli ftsK1 mutation attenuates the induction of sigma(s)-dependent genes upon transition to stationary phase

Diez, A A ; Tunlid, Anders LU and Nyström, T (2002) In FEMS Microbiology Letters 206(1). p.19-23
Abstract
A mutation in the cell division gene ftsK causes super-induction of sigma(70)-dependent stress defense genes, such as uspA, during entry of cells into stationary phase. In contrast, we report here that stationary phase induction of sigma(S)-dependent genes, uspB and cfa, is attenuated and that sigma(S) accumulates at a lower rate in ftsK1 cells. Ectopic overexpression of rpoS restored induction of the rpoS regulon in the ftsK mutant, as did a deletion in the recA gene. Thus, a mutation in the cell division gene,ftsY, uncouples the otherwise coordinated induction of sigma(S)-dependent genes and the universal stress response gene, uspA, during entry into stationary phase. (C) 2002 Federation of European Microbiological Societies, Published... (More)
A mutation in the cell division gene ftsK causes super-induction of sigma(70)-dependent stress defense genes, such as uspA, during entry of cells into stationary phase. In contrast, we report here that stationary phase induction of sigma(S)-dependent genes, uspB and cfa, is attenuated and that sigma(S) accumulates at a lower rate in ftsK1 cells. Ectopic overexpression of rpoS restored induction of the rpoS regulon in the ftsK mutant, as did a deletion in the recA gene. Thus, a mutation in the cell division gene,ftsY, uncouples the otherwise coordinated induction of sigma(S)-dependent genes and the universal stress response gene, uspA, during entry into stationary phase. (C) 2002 Federation of European Microbiological Societies, Published by Elsevier Science B.V. All rights reserved. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
FEMS Microbiology Letters
volume
206
issue
1
pages
19 - 23
publisher
Oxford University Press
external identifiers
  • pmid:11786251
  • wos:000173284600003
  • scopus:0037005897
ISSN
1574-6968
DOI
10.1016/S0378-1097(01)00509-2
language
English
LU publication?
yes
id
1ee4618d-caba-4a9a-ae5f-f57b1aa6c0fd (old id 146932)
date added to LUP
2016-04-01 15:59:38
date last changed
2024-02-26 10:51:45
@article{1ee4618d-caba-4a9a-ae5f-f57b1aa6c0fd,
  abstract     = {{A mutation in the cell division gene ftsK causes super-induction of sigma(70)-dependent stress defense genes, such as uspA, during entry of cells into stationary phase. In contrast, we report here that stationary phase induction of sigma(S)-dependent genes, uspB and cfa, is attenuated and that sigma(S) accumulates at a lower rate in ftsK1 cells. Ectopic overexpression of rpoS restored induction of the rpoS regulon in the ftsK mutant, as did a deletion in the recA gene. Thus, a mutation in the cell division gene,ftsY, uncouples the otherwise coordinated induction of sigma(S)-dependent genes and the universal stress response gene, uspA, during entry into stationary phase. (C) 2002 Federation of European Microbiological Societies, Published by Elsevier Science B.V. All rights reserved.}},
  author       = {{Diez, A A and Tunlid, Anders and Nyström, T}},
  issn         = {{1574-6968}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{19--23}},
  publisher    = {{Oxford University Press}},
  series       = {{FEMS Microbiology Letters}},
  title        = {{The Escherichia coli ftsK1 mutation attenuates the induction of sigma(s)-dependent genes upon transition to stationary phase}},
  url          = {{http://dx.doi.org/10.1016/S0378-1097(01)00509-2}},
  doi          = {{10.1016/S0378-1097(01)00509-2}},
  volume       = {{206}},
  year         = {{2002}},
}