Laminins.
(2010) In Cell and Tissue Research 339. p.259-268- Abstract
- Laminins are cell adhesion molecules that comprise a family of glycoproteins found predominantly in basement membranes, which are the thin sheets of extracellular matrix that underlie epithelial and endothelial cells and surround muscle cells, Schwann cells, and fat cells. Many laminins self-assemble to form networks that remain in close association with cells through interactions with cell surface receptors. Laminins are vital for many physiological functions. They are essential for early embryonic development and organogenesis and have crucial functions in several tissues including muscle, nerve, skin, kidney, lung, and the vasculature. A great wealth of data on laminins is available, and an in-depth description is not attempted here. In... (More)
- Laminins are cell adhesion molecules that comprise a family of glycoproteins found predominantly in basement membranes, which are the thin sheets of extracellular matrix that underlie epithelial and endothelial cells and surround muscle cells, Schwann cells, and fat cells. Many laminins self-assemble to form networks that remain in close association with cells through interactions with cell surface receptors. Laminins are vital for many physiological functions. They are essential for early embryonic development and organogenesis and have crucial functions in several tissues including muscle, nerve, skin, kidney, lung, and the vasculature. A great wealth of data on laminins is available, and an in-depth description is not attempted here. In this review, I will instead provide a snapshot of laminin structure, tissue distribution, and interactions with other matrix molecules and receptors and briefly describe laminin mutations in mice and humans. Several illuminating and timely reviews are cited that can be consulted for references to original articles and more detailed information concerning laminins. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1469574
- author
- Durbeej-Hjalt, Madeleine LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cell and Tissue Research
- volume
- 339
- pages
- 259 - 268
- publisher
- Springer
- external identifiers
-
- wos:000273953300021
- pmid:19693542
- scopus:72449128021
- pmid:19693542
- ISSN
- 1432-0878
- DOI
- 10.1007/s00441-009-0838-2
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cell and Matrix Biology (LUR000002), Muscle biology (013212015)
- id
- 724009bb-0c2c-4f55-a7b4-da5065b13a1b (old id 1469574)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19693542?dopt=Abstract
- date added to LUP
- 2016-04-04 08:56:58
- date last changed
- 2022-04-23 18:36:58
@article{724009bb-0c2c-4f55-a7b4-da5065b13a1b,
abstract = {{Laminins are cell adhesion molecules that comprise a family of glycoproteins found predominantly in basement membranes, which are the thin sheets of extracellular matrix that underlie epithelial and endothelial cells and surround muscle cells, Schwann cells, and fat cells. Many laminins self-assemble to form networks that remain in close association with cells through interactions with cell surface receptors. Laminins are vital for many physiological functions. They are essential for early embryonic development and organogenesis and have crucial functions in several tissues including muscle, nerve, skin, kidney, lung, and the vasculature. A great wealth of data on laminins is available, and an in-depth description is not attempted here. In this review, I will instead provide a snapshot of laminin structure, tissue distribution, and interactions with other matrix molecules and receptors and briefly describe laminin mutations in mice and humans. Several illuminating and timely reviews are cited that can be consulted for references to original articles and more detailed information concerning laminins.}},
author = {{Durbeej-Hjalt, Madeleine}},
issn = {{1432-0878}},
language = {{eng}},
pages = {{259--268}},
publisher = {{Springer}},
series = {{Cell and Tissue Research}},
title = {{Laminins.}},
url = {{http://dx.doi.org/10.1007/s00441-009-0838-2}},
doi = {{10.1007/s00441-009-0838-2}},
volume = {{339}},
year = {{2010}},
}