Different equations to combine creatinine and cystatin C to predict GFR. Arithmetic mean of existing equations performs as well as complex combinations
Nyman, Ulf ; Grubb, Anders LU
; Sterner, Gunnar
LU
and Björk, Jonas
LU
(2009)
In Scandinavian Journal of Clinical & Laboratory Investigation
69(5).
p.619-627
- Abstract
- Purpose: To test various ways of combining creatinine and cystatin C in equations to predict glomerular filtration rate (GFR). Material and methods: Performance of the following expressions to predict GFR was compared with measured GFR (iohexol clearance, mL/min/1.73 m(2)) in 857 patients: (i) Lund-Malmo creatinine equation, (ii) Grubb cystatin C equation, (iii) arithmetic mean of (1) and (2), (iv) geometric mean of (1) and (2), (v) linear regression on (1) and (2), (vi) regression on (1) and cystatin C, and (vii) regression on creatinine, cystatin C, age and gender. Results: For the entire cohort median percent error (bias) was <5% for all expressions, though all expressions tended to underestimate (<8.3 to <15.8%) GFR at levels... (More)
- Purpose: To test various ways of combining creatinine and cystatin C in equations to predict glomerular filtration rate (GFR). Material and methods: Performance of the following expressions to predict GFR was compared with measured GFR (iohexol clearance, mL/min/1.73 m(2)) in 857 patients: (i) Lund-Malmo creatinine equation, (ii) Grubb cystatin C equation, (iii) arithmetic mean of (1) and (2), (iv) geometric mean of (1) and (2), (v) linear regression on (1) and (2), (vi) regression on (1) and cystatin C, and (vii) regression on creatinine, cystatin C, age and gender. Results: For the entire cohort median percent error (bias) was <5% for all expressions, though all expressions tended to underestimate (<8.3 to <15.8%) GFR at levels <90 mL/min/1.73 m(2). The five expressions combining creatinine and cystatin C significantly improved correlation and accuracy (p < 0.001) within 15 and 30% of measured GFR compared with the equations based on the separate analytes and with no significant difference between the five expressions. In a subgroup of patients with neurological disease and muscle atrophy the cystatin C equation performed better than the expressions combining creatinine and cystatin C. Conclusion: Simply calculating the arithmetic mean of predicted GFR based on separate creatinine and cystatin C equations performs equally well as more complex equations. Reporting GFR based on separate creatinine and cystatin C equations, and their arithmetic mean also has the definite advantage that the physician can choose the estimated GFR, most appropriate depending on the clinical setting and patient characteristics. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1474944
- author
- Nyman, Ulf
; Grubb, Anders
LU
; Sterner, Gunnar
LU
and Björk, Jonas
LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- glomerular filtration rate, Kidney disease, kidney function tests, renal insufficiency
- in
- Scandinavian Journal of Clinical & Laboratory Investigation
- volume
- 69
- issue
- 5
- pages
- 619 - 627
- publisher
- Informa Healthcare
- external identifiers
-
- wos:000269541400013
- scopus:70249092880
- pmid:19731180
- ISSN
- 1502-7686
- DOI
- 10.1080/00365510902946992
- language
- English
- LU publication?
- yes
- id
- 477b85d2-1a72-4392-8f16-18e22a9ce2d0 (old id 1474944)
- date added to LUP
- 2016-04-01 14:21:05
- date last changed
- 2023-01-04 04:09:49
@article{477b85d2-1a72-4392-8f16-18e22a9ce2d0,
abstract = {{Purpose: To test various ways of combining creatinine and cystatin C in equations to predict glomerular filtration rate (GFR). Material and methods: Performance of the following expressions to predict GFR was compared with measured GFR (iohexol clearance, mL/min/1.73 m(2)) in 857 patients: (i) Lund-Malmo creatinine equation, (ii) Grubb cystatin C equation, (iii) arithmetic mean of (1) and (2), (iv) geometric mean of (1) and (2), (v) linear regression on (1) and (2), (vi) regression on (1) and cystatin C, and (vii) regression on creatinine, cystatin C, age and gender. Results: For the entire cohort median percent error (bias) was <5% for all expressions, though all expressions tended to underestimate (<8.3 to <15.8%) GFR at levels <90 mL/min/1.73 m(2). The five expressions combining creatinine and cystatin C significantly improved correlation and accuracy (p < 0.001) within 15 and 30% of measured GFR compared with the equations based on the separate analytes and with no significant difference between the five expressions. In a subgroup of patients with neurological disease and muscle atrophy the cystatin C equation performed better than the expressions combining creatinine and cystatin C. Conclusion: Simply calculating the arithmetic mean of predicted GFR based on separate creatinine and cystatin C equations performs equally well as more complex equations. Reporting GFR based on separate creatinine and cystatin C equations, and their arithmetic mean also has the definite advantage that the physician can choose the estimated GFR, most appropriate depending on the clinical setting and patient characteristics.}},
author = {{Nyman, Ulf and Grubb, Anders and Sterner, Gunnar and Björk, Jonas}},
issn = {{1502-7686}},
keywords = {{glomerular filtration rate; Kidney disease; kidney function tests; renal insufficiency}},
language = {{eng}},
number = {{5}},
pages = {{619--627}},
publisher = {{Informa Healthcare}},
series = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
title = {{Different equations to combine creatinine and cystatin C to predict GFR. Arithmetic mean of existing equations performs as well as complex combinations}},
url = {{http://dx.doi.org/10.1080/00365510902946992}},
doi = {{10.1080/00365510902946992}},
volume = {{69}},
year = {{2009}},
}