An Mhc class I allele associated to the expression of T-dependent immune response in the house sparrow
(2005) In Immunogenetics 57(10). p.782-789- Abstract
- The major histocompatibility complex (Mhc) encodes for highly variable molecules, responsible for foreign antigen recognition and subsequent activation of immune responses in hosts. Mhc polymorphism should hence be related to pathogen resistance and immune activity, with individuals that carry either a higher diversity of Mhc alleles or one specific Mhc allele exhibiting a stronger immune response to a given antigen. Links between Mhc alleles and immune activity have never been explored in natural populations of vertebrates. To fill this gap, we challenged house sparrows (Passer domesticus) with two T-dependent antigens (phytohemagglutinin and sheep red blood cells) and examined both primary and secondary immune responses in relation to... (More)
- The major histocompatibility complex (Mhc) encodes for highly variable molecules, responsible for foreign antigen recognition and subsequent activation of immune responses in hosts. Mhc polymorphism should hence be related to pathogen resistance and immune activity, with individuals that carry either a higher diversity of Mhc alleles or one specific Mhc allele exhibiting a stronger immune response to a given antigen. Links between Mhc alleles and immune activity have never been explored in natural populations of vertebrates. To fill this gap, we challenged house sparrows (Passer domesticus) with two T-dependent antigens (phytohemagglutinin and sheep red blood cells) and examined both primary and secondary immune responses in relation to their Mhc class I genotypes. The total number of Mhc alleles had no influence on either primary or secondary response to the two antigens. One particular Mhc allele, however, was associated with an increased response to both antigens. Our results point toward a contribution of the Mhc, or of other genes in linkage disequilibrium with the Mhc, in the regulation of immune responses in a wild animal species. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/149181
- author
- Bonneaud, C ; Richard, M ; Faivre, B ; Westerdahl, Helena LU and Sorci, G
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunogenetics
- volume
- 57
- issue
- 10
- pages
- 782 - 789
- publisher
- Springer
- external identifiers
-
- pmid:16189664
- wos:000233239500008
- scopus:27744514294
- pmid:16189664
- ISSN
- 1432-1211
- DOI
- 10.1007/s00251-005-0046-5
- language
- English
- LU publication?
- yes
- id
- b46b055c-33ac-430d-843a-0b1b012d4142 (old id 149181)
- date added to LUP
- 2016-04-01 11:59:24
- date last changed
- 2022-03-28 18:34:01
@article{b46b055c-33ac-430d-843a-0b1b012d4142,
abstract = {{The major histocompatibility complex (Mhc) encodes for highly variable molecules, responsible for foreign antigen recognition and subsequent activation of immune responses in hosts. Mhc polymorphism should hence be related to pathogen resistance and immune activity, with individuals that carry either a higher diversity of Mhc alleles or one specific Mhc allele exhibiting a stronger immune response to a given antigen. Links between Mhc alleles and immune activity have never been explored in natural populations of vertebrates. To fill this gap, we challenged house sparrows (Passer domesticus) with two T-dependent antigens (phytohemagglutinin and sheep red blood cells) and examined both primary and secondary immune responses in relation to their Mhc class I genotypes. The total number of Mhc alleles had no influence on either primary or secondary response to the two antigens. One particular Mhc allele, however, was associated with an increased response to both antigens. Our results point toward a contribution of the Mhc, or of other genes in linkage disequilibrium with the Mhc, in the regulation of immune responses in a wild animal species.}},
author = {{Bonneaud, C and Richard, M and Faivre, B and Westerdahl, Helena and Sorci, G}},
issn = {{1432-1211}},
language = {{eng}},
number = {{10}},
pages = {{782--789}},
publisher = {{Springer}},
series = {{Immunogenetics}},
title = {{An Mhc class I allele associated to the expression of T-dependent immune response in the house sparrow}},
url = {{http://dx.doi.org/10.1007/s00251-005-0046-5}},
doi = {{10.1007/s00251-005-0046-5}},
volume = {{57}},
year = {{2005}},
}