Chapter 12 - Molecular mechanisms of l-DOPA-induced dyskinesia
Cenci, M. Angela LU
and Ferrario, Juan
(2025)
35.
p.235-249
- Abstract
- l-DOPA-induced dyskinesia (LID) is a prevalent complication of dopamine replacement therapy in Parkinson’s disease. In addition to its clinical importance, LID represents a paradigm to unravel how altered signaling downstream of dopamine receptors can disrupt mechanisms of synaptic plasticity and motor information processing in the cortico-basal ganglia network. This chapter focuses on experimental studies that have linked LID to aberrant dopamine receptor-mediated signaling and transcriptional changes in the striatum. After losing their dopamine input, striatal spiny projection neurons respond to l-DOPA with an excessive activation of both canonical and non-canonical signaling pathways, leading to extensive changes to gene, and protein... (More)
- l-DOPA-induced dyskinesia (LID) is a prevalent complication of dopamine replacement therapy in Parkinson’s disease. In addition to its clinical importance, LID represents a paradigm to unravel how altered signaling downstream of dopamine receptors can disrupt mechanisms of synaptic plasticity and motor information processing in the cortico-basal ganglia network. This chapter focuses on experimental studies that have linked LID to aberrant dopamine receptor-mediated signaling and transcriptional changes in the striatum. After losing their dopamine input, striatal spiny projection neurons respond to l-DOPA with an excessive activation of both canonical and non-canonical signaling pathways, leading to extensive changes to gene, and protein expression that have long-lasting functional consequences. Molecular studies on LID provide important pathophysiological clues and reveal targets for future therapies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/14a4bb29-116b-4621-be43-a88d480f8ea0
- author
- Cenci, M. Angela
LU
and Ferrario, Juan
- organization
- publishing date
- 2025
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Basal ganglia, Dopamine, Intracellular signaling, Movement disorders, Parkinsonism
- host publication
- Handbook of Parkinson's Disease Mechanisms
- editor
- Moratalla, Rosario and Murer, Mario Gustavo
- volume
- 35
- pages
- 235 - 249
- publisher
- Elsevier
- external identifiers
-
- scopus:105021264743
- DOI
- 10.1016/B978-0-443-21992-4.00023-3
- language
- English
- LU publication?
- yes
- id
- 14a4bb29-116b-4621-be43-a88d480f8ea0
- alternative location
- https://www.sciencedirect.com/science/article/pii/B9780443219924000233
- date added to LUP
- 2025-12-01 15:41:32
- date last changed
- 2025-12-02 08:36:12
@inbook{14a4bb29-116b-4621-be43-a88d480f8ea0,
abstract = {{l-DOPA-induced dyskinesia (LID) is a prevalent complication of dopamine replacement therapy in Parkinson’s disease. In addition to its clinical importance, LID represents a paradigm to unravel how altered signaling downstream of dopamine receptors can disrupt mechanisms of synaptic plasticity and motor information processing in the cortico-basal ganglia network. This chapter focuses on experimental studies that have linked LID to aberrant dopamine receptor-mediated signaling and transcriptional changes in the striatum. After losing their dopamine input, striatal spiny projection neurons respond to l-DOPA with an excessive activation of both canonical and non-canonical signaling pathways, leading to extensive changes to gene, and protein expression that have long-lasting functional consequences. Molecular studies on LID provide important pathophysiological clues and reveal targets for future therapies.}},
author = {{Cenci, M. Angela and Ferrario, Juan}},
booktitle = {{Handbook of Parkinson's Disease Mechanisms}},
editor = {{Moratalla, Rosario and Murer, Mario Gustavo}},
keywords = {{Basal ganglia; Dopamine; Intracellular signaling; Movement disorders; Parkinsonism}},
language = {{eng}},
pages = {{235--249}},
publisher = {{Elsevier}},
title = {{Chapter 12 - Molecular mechanisms of l-DOPA-induced dyskinesia}},
url = {{http://dx.doi.org/10.1016/B978-0-443-21992-4.00023-3}},
doi = {{10.1016/B978-0-443-21992-4.00023-3}},
volume = {{35}},
year = {{2025}},
}