Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment.
(2005) In Hormone Research 64(Suppl 3). p.45-50- Abstract
- Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effect of GH on insulin sensitivity and a deterioration in glucose tolerance. Research has shown that GH induces insulin resistance by the stimulation of lipolysis and a concomitant switch from oxidation of glucose to oxidation of lipids, during both acute and chronic treatment. However, although this is a consistent effect of GH therapy, it does not... (More)
- Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effect of GH on insulin sensitivity and a deterioration in glucose tolerance. Research has shown that GH induces insulin resistance by the stimulation of lipolysis and a concomitant switch from oxidation of glucose to oxidation of lipids, during both acute and chronic treatment. However, although this is a consistent effect of GH therapy, it does not mean per se that it leads to abnormal glucose tolerance and diabetes mellitus. This article discusses this and other potential long-term metabolic effects of GH, and raises a number of questions to be addressed by future research. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/150077
- author
- Groop, Leif LU ; Segerlantz, Mikael LU and Bramnert, Margareta LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- insulin sensitivity, adults, growth hormone, treatment, growth hormone deficiency
- in
- Hormone Research
- volume
- 64
- issue
- Suppl 3
- pages
- 45 - 50
- publisher
- Karger
- external identifiers
-
- wos:000235194200008
- scopus:31544438039
- ISSN
- 0301-0163
- DOI
- 10.1159/000089317
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Endocrinology (013241500), Diabetes and Endocrinology (013241530)
- id
- 17e42f4c-195c-4fc7-9a1d-73fe501bcbc3 (old id 150077)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16439844&dopt=Abstract
- date added to LUP
- 2016-04-01 16:56:29
- date last changed
- 2024-01-11 17:44:07
@article{17e42f4c-195c-4fc7-9a1d-73fe501bcbc3,
abstract = {{Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role. The introduction of recombinant growth hormone (GH) for the treatment of GHD has opened up new treatment avenues but has also raised concerns about possible untoward long-term metabolic effects of GH, such as the potential effect of GH on insulin sensitivity and a deterioration in glucose tolerance. Research has shown that GH induces insulin resistance by the stimulation of lipolysis and a concomitant switch from oxidation of glucose to oxidation of lipids, during both acute and chronic treatment. However, although this is a consistent effect of GH therapy, it does not mean per se that it leads to abnormal glucose tolerance and diabetes mellitus. This article discusses this and other potential long-term metabolic effects of GH, and raises a number of questions to be addressed by future research.}},
author = {{Groop, Leif and Segerlantz, Mikael and Bramnert, Margareta}},
issn = {{0301-0163}},
keywords = {{insulin sensitivity; adults; growth hormone; treatment; growth hormone deficiency}},
language = {{eng}},
number = {{Suppl 3}},
pages = {{45--50}},
publisher = {{Karger}},
series = {{Hormone Research}},
title = {{Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment.}},
url = {{http://dx.doi.org/10.1159/000089317}},
doi = {{10.1159/000089317}},
volume = {{64}},
year = {{2005}},
}