Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor.
(2006) In European Journal of Pharmacology 531(1-3). p.259-263- Abstract
- The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT(1) and AT(2) receptor blockers candesartan and PD 123319. Both angiotensin AT(1) and AT(2) receptors were detected on the endothelium by imnitmohistochemistry. (c) 2005... (More)
- The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT(1) and AT(2) receptor blockers candesartan and PD 123319. Both angiotensin AT(1) and AT(2) receptors were detected on the endothelium by imnitmohistochemistry. (c) 2005 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/150341
- author
- Wackenfors, Angelica LU ; Vikman, Petter LU ; Nilsson, Elisabeth LU ; Edvinsson, Lars LU and Malmsjö, Malin LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cerebral artery, hyperpolarising factor, angiotensin II, endothelium-derived, vasodilatation
- in
- European Journal of Pharmacology
- volume
- 531
- issue
- 1-3
- pages
- 259 - 263
- publisher
- Elsevier
- external identifiers
-
- wos:000235566200039
- pmid:16410000
- scopus:32044470234
- ISSN
- 1879-0712
- DOI
- 10.1016/j.ejphar.2005.11.064
- language
- English
- LU publication?
- yes
- id
- 1d4e1ca1-6c49-4fc7-a703-28a780ab705c (old id 150341)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16410000&dopt=Abstract
- date added to LUP
- 2016-04-01 12:11:03
- date last changed
- 2024-01-08 11:25:09
@article{1d4e1ca1-6c49-4fc7-a703-28a780ab705c, abstract = {{The angiotensin II-induced vasodilatation was evaluated in rat middle cerebral artery, especially regarding endothelium-derived hyperpolarising factor (EDHF), by use of a pressurised arteriograph. The angiotensin II dilatation was partly antagonised by inhibitors of nitric oxide synthase and cyclo-oxygenase. The remaining dilatation was inhibited by the potassium channel blockers, charybdotoxin and apamin, providing direct evidence that angiotensin II induces EDHF-mediated dilatation in cerebral arteries. The angiotensin II dilatation was blocked by the angiotensin AT(1) and AT(2) receptor blockers candesartan and PD 123319. Both angiotensin AT(1) and AT(2) receptors were detected on the endothelium by imnitmohistochemistry. (c) 2005 Elsevier B.V. All rights reserved.}}, author = {{Wackenfors, Angelica and Vikman, Petter and Nilsson, Elisabeth and Edvinsson, Lars and Malmsjö, Malin}}, issn = {{1879-0712}}, keywords = {{cerebral artery; hyperpolarising factor; angiotensin II; endothelium-derived; vasodilatation}}, language = {{eng}}, number = {{1-3}}, pages = {{259--263}}, publisher = {{Elsevier}}, series = {{European Journal of Pharmacology}}, title = {{Angiotensin II-induced vasodilatation in cerebral arteries is mediated by endothelium-derived hyperpolarising factor.}}, url = {{https://lup.lub.lu.se/search/files/2817317/625265.pdf}}, doi = {{10.1016/j.ejphar.2005.11.064}}, volume = {{531}}, year = {{2006}}, }