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Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase

Kempe, Maria LU and Mosbach, Klaus LU (1994) In Journal of Chromatography A 664(2). p.276-279
Abstract
A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Chromatography A
volume
664
issue
2
pages
276 - 279
publisher
Elsevier
external identifiers
  • scopus:0028196748
ISSN
0021-9673
DOI
10.1016/0021-9673(94)87016-0
language
English
LU publication?
yes
id
8bcd2020-84b6-4570-bdfa-e41082217ca3 (old id 1516062)
date added to LUP
2016-04-01 17:02:57
date last changed
2021-08-29 05:10:34
@article{8bcd2020-84b6-4570-bdfa-e41082217ca3,
  abstract     = {{A synthetic polymer selective for (S)-naproxen was prepared by molecular imprinting. 4-Vinylpyridine and ethylene glycol dimethacrylate were copolymerised in the presence of the template, (S)-naproxen. The template was extracted from the polymer, leaving specific recognition sites, complementary to the template. The polymer was utilized as a stationary phase in HPLC. Racemic naproxen was efficiently resolved on the polymer. Furthermore, the polymer was able to separate naproxen from the structurally related ibuprofen and ketoprofen.}},
  author       = {{Kempe, Maria and Mosbach, Klaus}},
  issn         = {{0021-9673}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{276--279}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Chromatography A}},
  title        = {{Direct resolution of naproxen on a non-covalently molecularly imprinted chiral stationary phase}},
  url          = {{http://dx.doi.org/10.1016/0021-9673(94)87016-0}},
  doi          = {{10.1016/0021-9673(94)87016-0}},
  volume       = {{664}},
  year         = {{1994}},
}