Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies
(2009) In Haematologica 94(11). p.1581-1589- Abstract
- There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying... (More)
- There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1517726
- author
- Kristinsson, Sigurdur Y. ; Goldin, Lynn R. ; Bjorkholm, Magnus ; Koshiol, Jill ; Turesson, Ingemar LU and Landgren, Ola
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- susceptibility, familial aggregation, multiple myeloma, MGUS, lymphoma, Waldenstrom's macroglobulinemia, lymphoplasmacytic lymphoma, leukemia, chronic lymphocytic, Hodgkin's lymphoma, non-Hodgkin's lymphoma, immune-related, autoimmune disease, rheumatoid arthritis, monoclonal, B-cell lymphocytosis
- in
- Haematologica
- volume
- 94
- issue
- 11
- pages
- 1581 - 1589
- publisher
- Ferrata Storti Foundation
- external identifiers
-
- wos:000272165800015
- scopus:70449337660
- pmid:19586941
- ISSN
- 1592-8721
- DOI
- 10.3324/haematol.2009.008979
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)
- id
- 42c05c61-27ba-44a9-a457-2f44ff2ba68b (old id 1517726)
- date added to LUP
- 2016-04-01 14:09:57
- date last changed
- 2022-01-27 23:06:49
@article{42c05c61-27ba-44a9-a457-2f44ff2ba68b,
abstract = {{There are data to support a role for genetic and immune-related factors in the pathogenesis of lymphomas and plasma cell diseases. In this paper, we review our published large population-based studies and other relevant studies in Hodgkin's and non-Hodgkin's lymphomas, multiple myeloma, and the precursor condition monoclonal gammopathy of undetermined significance. We discuss the overlap in risk factors between related malignancies and explore the underlying mechanisms. Based on these studies, we provide clinical implications and discuss the relevance of these data for patient counseling and clinical follow-up. Finally, we suggest future directions for new studies designed to increase our current knowledge and to define underlying biological mechanisms of our findings.}},
author = {{Kristinsson, Sigurdur Y. and Goldin, Lynn R. and Bjorkholm, Magnus and Koshiol, Jill and Turesson, Ingemar and Landgren, Ola}},
issn = {{1592-8721}},
keywords = {{susceptibility; familial aggregation; multiple myeloma; MGUS; lymphoma; Waldenstrom's macroglobulinemia; lymphoplasmacytic lymphoma; leukemia; chronic lymphocytic; Hodgkin's lymphoma; non-Hodgkin's lymphoma; immune-related; autoimmune disease; rheumatoid arthritis; monoclonal; B-cell lymphocytosis}},
language = {{eng}},
number = {{11}},
pages = {{1581--1589}},
publisher = {{Ferrata Storti Foundation}},
series = {{Haematologica}},
title = {{Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies}},
url = {{http://dx.doi.org/10.3324/haematol.2009.008979}},
doi = {{10.3324/haematol.2009.008979}},
volume = {{94}},
year = {{2009}},
}