From the bone marrow to the thymus: the road map of early stages of T-cell development.
(2009) In Critical Reviews in Immunology 29(6). p.487-530- Abstract
- The thymus produces new T cells throughout life but has no self-renewing ability and requires replenishment and recruitment of progenitors derived from the bone marrow. Despite the progress in delineation of mature blood cell development several questions remain regarding T lymphopoiesis. Understanding the developmental stages from multipotent hematopoietic stem cells (HSCs) to the T-cell lineage-restricted progenitors has many potential clinical implications as it is important for understanding malignant transformation in T-cell cancer, accelerating T-cell regeneration after bone marrow transplantation and chemotherapy, and establishing new therapies to treat T-cell immune deficiencies. This review focuses on the steps leading from the... (More)
- The thymus produces new T cells throughout life but has no self-renewing ability and requires replenishment and recruitment of progenitors derived from the bone marrow. Despite the progress in delineation of mature blood cell development several questions remain regarding T lymphopoiesis. Understanding the developmental stages from multipotent hematopoietic stem cells (HSCs) to the T-cell lineage-restricted progenitors has many potential clinical implications as it is important for understanding malignant transformation in T-cell cancer, accelerating T-cell regeneration after bone marrow transplantation and chemotherapy, and establishing new therapies to treat T-cell immune deficiencies. This review focuses on the steps leading from the HSCs in the bone marrow to the lineage committed T cells inside the thymus. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1553086
- author
- Sitnicka Quinn, Ewa LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- T-Lymphocytes: immunology, Thymus Gland: cytology, Thymus Gland: immunology, Bone Marrow: immunology, T-Lymphocytes: cytology
- in
- Critical Reviews in Immunology
- volume
- 29
- issue
- 6
- pages
- 487 - 530
- publisher
- Begell House
- external identifiers
-
- wos:000274695900003
- pmid:20121697
- scopus:76749136189
- ISSN
- 1040-8401
- DOI
- 10.1615/CritRevImmunol.v29.i6.30
- language
- English
- LU publication?
- yes
- id
- bb2b3f8b-9959-4a64-83c1-3910a8fbfd32 (old id 1553086)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20121697?dopt=Abstract
- date added to LUP
- 2016-04-04 08:15:00
- date last changed
- 2022-08-08 07:09:48
@article{bb2b3f8b-9959-4a64-83c1-3910a8fbfd32,
abstract = {{The thymus produces new T cells throughout life but has no self-renewing ability and requires replenishment and recruitment of progenitors derived from the bone marrow. Despite the progress in delineation of mature blood cell development several questions remain regarding T lymphopoiesis. Understanding the developmental stages from multipotent hematopoietic stem cells (HSCs) to the T-cell lineage-restricted progenitors has many potential clinical implications as it is important for understanding malignant transformation in T-cell cancer, accelerating T-cell regeneration after bone marrow transplantation and chemotherapy, and establishing new therapies to treat T-cell immune deficiencies. This review focuses on the steps leading from the HSCs in the bone marrow to the lineage committed T cells inside the thymus.}},
author = {{Sitnicka Quinn, Ewa}},
issn = {{1040-8401}},
keywords = {{T-Lymphocytes: immunology; Thymus Gland: cytology; Thymus Gland: immunology; Bone Marrow: immunology; T-Lymphocytes: cytology}},
language = {{eng}},
number = {{6}},
pages = {{487--530}},
publisher = {{Begell House}},
series = {{Critical Reviews in Immunology}},
title = {{From the bone marrow to the thymus: the road map of early stages of T-cell development.}},
url = {{http://dx.doi.org/10.1615/CritRevImmunol.v29.i6.30}},
doi = {{10.1615/CritRevImmunol.v29.i6.30}},
volume = {{29}},
year = {{2009}},
}