Genetically modified animals in research : an analysis of applications submitted to ethics committees on animal experimentation in Sweden
(2005) In Animal Welfare 14(3). p.239-248- Abstract
- The use of genetically modified animals in biomedical research has increased during recent years and its ethical aspects have been subject to academic discussion. In order to make this discussion more concrete, we analyzed applications submitted to animal ethics committees in Sweden in 2002. The aim was to investigate the researchers’ statements concerning the production and use of genetically modified animals as well as the committees’ assessments. For our analysis, we constructed an Analytic Form. In part, we followed the questions and categories of the mandatory Application Form, noting for example species, degree of severity as regards pain and distress, handling of pain, and endpoints. In part, we created questions and categories of... (More)
- The use of genetically modified animals in biomedical research has increased during recent years and its ethical aspects have been subject to academic discussion. In order to make this discussion more concrete, we analyzed applications submitted to animal ethics committees in Sweden in 2002. The aim was to investigate the researchers’ statements concerning the production and use of genetically modified animals as well as the committees’ assessments. For our analysis, we constructed an Analytic Form. In part, we followed the questions and categories of the mandatory Application Form, noting for example species, degree of severity as regards pain and distress, handling of pain, and endpoints. In part, we created questions and categories of our own and classified the applications accordingly. We focused particularly on methods of production and on expected clinical symptoms due to genetic modification and experimental use. Our analysis – partly quantitative, partly qualitative – showed, inter alia, that applications were often approved in spite of insufficient information regarding ethically relevant aspects, that the arguments for using genetically modified animals were often unclear, and that some applicants indicated awareness of the possibility of unintended welfare effects due to genetic modification, while others did not. We noted that many applicants stressed that certain GM animals were to be used without manifesting any clinical symptoms. This was obviously viewed as an ethical advantage. We found that obvious or minor clinical symptoms due to genetic modification were expected in more than a third of the applications. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/155429
- author
- Nordgren, Anders and Röcklinsberg, Helena LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- transgenic animals, animal welfare, animal experimentation, animal ethics, genetically modified animals, animal ethics committees
- in
- Animal Welfare
- volume
- 14
- issue
- 3
- pages
- 239 - 248
- publisher
- Universities Federation for Animal welfare
- external identifiers
-
- wos:000230860200008
- scopus:23044448822
- ISSN
- 0962-7286
- language
- English
- LU publication?
- yes
- id
- 2dd63aa6-13b3-4162-bb33-cd8a169e9961 (old id 155429)
- alternative location
- http://www.ingentaconnect.com/content/ufaw/aw/2005/00000014/00000003/art00008;jsessionid=1guqy1s9u9x7r.henrietta
- date added to LUP
- 2016-04-01 16:49:09
- date last changed
- 2022-01-28 22:23:10
@article{2dd63aa6-13b3-4162-bb33-cd8a169e9961,
abstract = {{The use of genetically modified animals in biomedical research has increased during recent years and its ethical aspects have been subject to academic discussion. In order to make this discussion more concrete, we analyzed applications submitted to animal ethics committees in Sweden in 2002. The aim was to investigate the researchers’ statements concerning the production and use of genetically modified animals as well as the committees’ assessments. For our analysis, we constructed an Analytic Form. In part, we followed the questions and categories of the mandatory Application Form, noting for example species, degree of severity as regards pain and distress, handling of pain, and endpoints. In part, we created questions and categories of our own and classified the applications accordingly. We focused particularly on methods of production and on expected clinical symptoms due to genetic modification and experimental use. Our analysis – partly quantitative, partly qualitative – showed, inter alia, that applications were often approved in spite of insufficient information regarding ethically relevant aspects, that the arguments for using genetically modified animals were often unclear, and that some applicants indicated awareness of the possibility of unintended welfare effects due to genetic modification, while others did not. We noted that many applicants stressed that certain GM animals were to be used without manifesting any clinical symptoms. This was obviously viewed as an ethical advantage. We found that obvious or minor clinical symptoms due to genetic modification were expected in more than a third of the applications.}},
author = {{Nordgren, Anders and Röcklinsberg, Helena}},
issn = {{0962-7286}},
keywords = {{transgenic animals; animal welfare; animal experimentation; animal ethics; genetically modified animals; animal ethics committees}},
language = {{eng}},
number = {{3}},
pages = {{239--248}},
publisher = {{Universities Federation for Animal welfare}},
series = {{Animal Welfare}},
title = {{Genetically modified animals in research : an analysis of applications submitted to ethics committees on animal experimentation in Sweden}},
url = {{http://www.ingentaconnect.com/content/ufaw/aw/2005/00000014/00000003/art00008;jsessionid=1guqy1s9u9x7r.henrietta}},
volume = {{14}},
year = {{2005}},
}