Activated protein C-protein C inhibitor complex: a new biological marker for aortic aneurysms.
(2006) In Journal of Vascular Surgery 43(5). p.935-939- Abstract
- Objective: The concentration of the complex between activated protein C (APC) and protein C inhibitor (PCI) is a measure of thrombin generation. We studied whether it can provide information useful for the diagnosis and treatment of arterial vascular disease. Methods: Blood was obtained from 429 vascular patients admitted consecutively during September 2004 to March 2005. The APC-PCI complex was measured by using a sandwich immunofluorometric method. The patients were divided into cohorts according to the planned treatment and compared with a control group of healthy individuals. Results: The APC-PCI complex concentration varied from 0.08 to 2.50 mu g/L. In the cohort of patients with aortic aneurysms (n = 78), the median APC-PCI value was... (More)
- Objective: The concentration of the complex between activated protein C (APC) and protein C inhibitor (PCI) is a measure of thrombin generation. We studied whether it can provide information useful for the diagnosis and treatment of arterial vascular disease. Methods: Blood was obtained from 429 vascular patients admitted consecutively during September 2004 to March 2005. The APC-PCI complex was measured by using a sandwich immunofluorometric method. The patients were divided into cohorts according to the planned treatment and compared with a control group of healthy individuals. Results: The APC-PCI complex concentration varied from 0.08 to 2.50 mu g/L. In the cohort of patients with aortic aneurysms (n = 78), the median APC-PCI value was 0.45 (10(th) to 90(th) percentile, 0.24-1.47), and values were clearly increased compared with all other cohorts (P <.0001). Patients with carotid disease (n = 73) yielded a median of 0.22 (10(th) to 90(th) percentile, 0.15-0.48). The median for claudicants (n = 74) was 0.26 mu g/L (10(th) to 90(th) percentile, 0.15-0.75), which was higher than in those (n = 97) with critical ischemia (0.20; 10(th) to 90(th) percentile, 0.13-0.36; P <.0023). The cohort with other forms of antherosclerotic disease (n = 40) had a median of 0.23 (10(th) to 90(th) percentile, 0.14-0.42), whereas the value for a cohort of 21 patients with venous disease was 0.19 (10(th) to 90(th) percentile, 0.10-0.34). The median was 0.15 (10(th) to 90(th) percentile, 0.10-0.23) for the control group (n = 121). Conclusions: Patients with atherosclerosis had an increased APC-PCI concentration that corresponded to increased generation of thrombin. Patients with aortic aneurysm had a threefold higher median concentration than the control group. We suggest that this remarkable increase is caused by the local activation of coagulation, and we surmise that APC-PCI measurements can be used as a screening tool to identify patients with aortic aneurysms. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/156967
- author
- Kölbel, Tilo LU ; Strandberg, Karin LU ; Mattiasson, Ingrid LU ; Stenflo, Johan LU and Lindblad, Bengt LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aortic Aneurysm, 80 and over, Intermittent Claudication: blood, Humans, Female, Enzyme Activation, Cohort Studies, Carotid Stenosis: diagnosis, Carotid Stenosis: blood, Biological Markers: blood, Atherosclerosis: diagnosis, Atherosclerosis: blood, Abdominal: diagnosis, Abdominal: blood, Aged, Adult, Intermittent Claudication: diagnosis, Ischemia: diagnosis, Ischemia: blood, Leg: blood supply, Male, Mass Screening, Middle Aged, Predictive Value of Tests, Protein C: metabolism, Protein C Inhibitor: blood, Reference Values, Research Support, Non-U.S. Gov't, Statistics, Thrombin: metabolism
- in
- Journal of Vascular Surgery
- volume
- 43
- issue
- 5
- pages
- 935 - 939
- publisher
- Mosby-Elsevier
- external identifiers
-
- wos:000237261400013
- pmid:16678686
- scopus:33646137368
- pmid:16678686
- ISSN
- 1097-6809
- DOI
- 10.1016/j.jvs.2006.01.019
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit for Clinical Vascular Disease Research (013242410), Clinical Chemistry, Malmö (013016000), Emergency medicine/Medicine/Surgery (013240200)
- id
- 3f8a36db-cb0c-47c4-be72-18b7e4988d8f (old id 156967)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16678686&dopt=Abstract
- date added to LUP
- 2016-04-01 15:51:49
- date last changed
- 2022-01-28 07:38:43
@article{3f8a36db-cb0c-47c4-be72-18b7e4988d8f, abstract = {{Objective: The concentration of the complex between activated protein C (APC) and protein C inhibitor (PCI) is a measure of thrombin generation. We studied whether it can provide information useful for the diagnosis and treatment of arterial vascular disease. Methods: Blood was obtained from 429 vascular patients admitted consecutively during September 2004 to March 2005. The APC-PCI complex was measured by using a sandwich immunofluorometric method. The patients were divided into cohorts according to the planned treatment and compared with a control group of healthy individuals. Results: The APC-PCI complex concentration varied from 0.08 to 2.50 mu g/L. In the cohort of patients with aortic aneurysms (n = 78), the median APC-PCI value was 0.45 (10(th) to 90(th) percentile, 0.24-1.47), and values were clearly increased compared with all other cohorts (P <.0001). Patients with carotid disease (n = 73) yielded a median of 0.22 (10(th) to 90(th) percentile, 0.15-0.48). The median for claudicants (n = 74) was 0.26 mu g/L (10(th) to 90(th) percentile, 0.15-0.75), which was higher than in those (n = 97) with critical ischemia (0.20; 10(th) to 90(th) percentile, 0.13-0.36; P <.0023). The cohort with other forms of antherosclerotic disease (n = 40) had a median of 0.23 (10(th) to 90(th) percentile, 0.14-0.42), whereas the value for a cohort of 21 patients with venous disease was 0.19 (10(th) to 90(th) percentile, 0.10-0.34). The median was 0.15 (10(th) to 90(th) percentile, 0.10-0.23) for the control group (n = 121). Conclusions: Patients with atherosclerosis had an increased APC-PCI concentration that corresponded to increased generation of thrombin. Patients with aortic aneurysm had a threefold higher median concentration than the control group. We suggest that this remarkable increase is caused by the local activation of coagulation, and we surmise that APC-PCI measurements can be used as a screening tool to identify patients with aortic aneurysms.}}, author = {{Kölbel, Tilo and Strandberg, Karin and Mattiasson, Ingrid and Stenflo, Johan and Lindblad, Bengt}}, issn = {{1097-6809}}, keywords = {{Aortic Aneurysm; 80 and over; Intermittent Claudication: blood; Humans; Female; Enzyme Activation; Cohort Studies; Carotid Stenosis: diagnosis; Carotid Stenosis: blood; Biological Markers: blood; Atherosclerosis: diagnosis; Atherosclerosis: blood; Abdominal: diagnosis; Abdominal: blood; Aged; Adult; Intermittent Claudication: diagnosis; Ischemia: diagnosis; Ischemia: blood; Leg: blood supply; Male; Mass Screening; Middle Aged; Predictive Value of Tests; Protein C: metabolism; Protein C Inhibitor: blood; Reference Values; Research Support; Non-U.S. Gov't; Statistics; Thrombin: metabolism}}, language = {{eng}}, number = {{5}}, pages = {{935--939}}, publisher = {{Mosby-Elsevier}}, series = {{Journal of Vascular Surgery}}, title = {{Activated protein C-protein C inhibitor complex: a new biological marker for aortic aneurysms.}}, url = {{http://dx.doi.org/10.1016/j.jvs.2006.01.019}}, doi = {{10.1016/j.jvs.2006.01.019}}, volume = {{43}}, year = {{2006}}, }