Drug transport in responding lipid membranes can be regulated by an external osmotic gradient
(2005) In Langmuir 21(23). p.10307-10310- Abstract
- In this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear transport behavior. The external gradient can thus act as a kind of switch for diffusive transport in the skin and in controlled release drug formulations.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/157303
- author
- Costa, Fatima LU ; Åberg, Christoffer LU ; Sousa, J J S and Sparr, Emma LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Langmuir
- volume
- 21
- issue
- 23
- pages
- 10307 - 10310
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000233129500014
- scopus:28044459214
- ISSN
- 0743-7463
- DOI
- 10.1021/la051947n
- language
- English
- LU publication?
- yes
- id
- a6aef334-9996-4a7c-a399-2403113ca723 (old id 157303)
- date added to LUP
- 2016-04-01 11:41:34
- date last changed
- 2022-01-26 08:50:28
@article{a6aef334-9996-4a7c-a399-2403113ca723, abstract = {{In this paper, we demonstrate, for the first time, how an external osmotic gradient can be used to regulate diffusion of solutes across a lipid membrane. We present experimental and theoretical studies of the transport of different solutes across a monoolein membrane in the presence of an external osmotic gradient. The osmotic gradient introduces phase transformations in the membrane, and it causes nonlinear transport behavior. The external gradient can thus act as a kind of switch for diffusive transport in the skin and in controlled release drug formulations.}}, author = {{Costa, Fatima and Åberg, Christoffer and Sousa, J J S and Sparr, Emma}}, issn = {{0743-7463}}, language = {{eng}}, number = {{23}}, pages = {{10307--10310}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Langmuir}}, title = {{Drug transport in responding lipid membranes can be regulated by an external osmotic gradient}}, url = {{http://dx.doi.org/10.1021/la051947n}}, doi = {{10.1021/la051947n}}, volume = {{21}}, year = {{2005}}, }