Industrial ultrafiltration systems for fermentation broth recovery
Lipnizki, Frank LU
(2001)
7th Nordic Filtration Symposium 2001
- Abstract
- In the food & beverage, biotech and pharma industry the use of ultrafiltration to recover fermentation broth is the state-of-the-art. These Ultrafiltration systems consist commonly of three stages: (1) pre-concentration stage, (2) diafiltration, and (3) final concentration. The process mode can be either batch or continuous. In the batch processes for all stages of the concentration the same modules are applied. Since high viscosity modules are not very effective at low viscosities and this can lead to high-energy consumption. Further, batch processes have a long retention time, which might cause problems in dealing with non-sterile products. These problems can be overcome by using a continuous process. However, continuous... (More)
- In the food & beverage, biotech and pharma industry the use of ultrafiltration to recover fermentation broth is the state-of-the-art. These Ultrafiltration systems consist commonly of three stages: (1) pre-concentration stage, (2) diafiltration, and (3) final concentration. The process mode can be either batch or continuous. In the batch processes for all stages of the concentration the same modules are applied. Since high viscosity modules are not very effective at low viscosities and this can lead to high-energy consumption. Further, batch processes have a long retention time, which might cause problems in dealing with non-sterile products. These problems can be overcome by using a continuous process. However, continuous processes are commonly associated with high consumption of diafiltration water, this problem can be overcome by using counter-current diafiltration as proposed by Madsen [1].
DSS has experience of more than 10,000 m2 installed membrane area for whole broth recovery in continuous ultrafiltration process with diafiltration. The heart of this process is a sophisticated automatic control systems ensuring that even at different feed streams a constant concentration in the permeate can be achieved. One example for an application on industrial scale is the recovery of fermentation broth in the antibiotic production. The feed stream is 6000 kg/h and the installed membrane area is 360 m2 of PVDF membranes, which produce a final product with a molecular weight of less than 500 Dalton. The plant consists of series of plate and frame modules DSS M39, made from polysulphone for a sanitary design. Cleaning in place (CIP) is carried out periodically over 2 hours including water flushing, alkaline cleaning and optional disinfecting. The cost for each CIP cycle are about 100 US$ excluding costs of heating and water. The investment costs for the project were about 2 million US$. The projected membrane life cycle is 2 years and leads additional operating costs of about 222 US$/m2. Overall, the DSS plant design of a continuous ultrafiltration plant with diafiltration overcomes problems of the batch mode process and leads to an improved production.
[1] R. F. Madsen (2001). Design of sanitary and sterile UF- and diafiltration plants. Separation and Purification Technology, 22/23, 79. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/15736f33-fcef-4ef3-a99c-997405029153
- author
- Lipnizki, Frank
LU
- publishing date
- 2001-08-27
- type
- Contribution to conference
- publication status
- published
- subject
- conference name
- 7th Nordic Filtration Symposium 2001
- conference location
- Copenhagen, Denmark
- conference dates
- 2001-08-27 - 2001-08-28
- language
- English
- LU publication?
- no
- id
- 15736f33-fcef-4ef3-a99c-997405029153
- date added to LUP
- 2019-05-15 08:14:01
- date last changed
- 2020-10-24 02:19:54
@misc{15736f33-fcef-4ef3-a99c-997405029153,
abstract = {{In the food & beverage, biotech and pharma industry the use of ultrafiltration to recover fermentation broth is the state-of-the-art. These Ultrafiltration systems consist commonly of three stages: (1) pre-concentration stage, (2) diafiltration, and (3) final concentration. The process mode can be either batch or continuous. In the batch processes for all stages of the concentration the same modules are applied. Since high viscosity modules are not very effective at low viscosities and this can lead to high-energy consumption. Further, batch processes have a long retention time, which might cause problems in dealing with non-sterile products. These problems can be overcome by using a continuous process. However, continuous processes are commonly associated with high consumption of diafiltration water, this problem can be overcome by using counter-current diafiltration as proposed by Madsen [1]. <br>
DSS has experience of more than 10,000 m2 installed membrane area for whole broth recovery in continuous ultrafiltration process with diafiltration. The heart of this process is a sophisticated automatic control systems ensuring that even at different feed streams a constant concentration in the permeate can be achieved. One example for an application on industrial scale is the recovery of fermentation broth in the antibiotic production. The feed stream is 6000 kg/h and the installed membrane area is 360 m2 of PVDF membranes, which produce a final product with a molecular weight of less than 500 Dalton. The plant consists of series of plate and frame modules DSS M39, made from polysulphone for a sanitary design. Cleaning in place (CIP) is carried out periodically over 2 hours including water flushing, alkaline cleaning and optional disinfecting. The cost for each CIP cycle are about 100 US$ excluding costs of heating and water. The investment costs for the project were about 2 million US$. The projected membrane life cycle is 2 years and leads additional operating costs of about 222 US$/m2. Overall, the DSS plant design of a continuous ultrafiltration plant with diafiltration overcomes problems of the batch mode process and leads to an improved production. <br>
<br>
[1] R. F. Madsen (2001). Design of sanitary and sterile UF- and diafiltration plants. Separation and Purification Technology, 22/23, 79.}},
author = {{Lipnizki, Frank}},
language = {{eng}},
month = {{08}},
title = {{Industrial ultrafiltration systems for fermentation broth recovery}},
year = {{2001}},
}