Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey
(2010) In American Journal of Kidney Diseases 55(3). p.485-496- Abstract
- Background: End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design: Cross-sectional survey. Setting & Participants: Total populations aged 20-60 years of 5 villages in Northwest Nicaragua: mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). Predictor or Factor: Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors. Outcomes: Serum creatinine (SCr) values greater than laboratory reference range for sex,... (More)
- Background: End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design: Cross-sectional survey. Setting & Participants: Total populations aged 20-60 years of 5 villages in Northwest Nicaragua: mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). Predictor or Factor: Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors. Outcomes: Serum creatinine (SCr) values greater than laboratory reference range for sex, estimated glomerular filtration rate <60 mL/min/1.73 m(2), proteinuria stratified in the low (dipstick protein excretion, 30-300 mg/dL) and high (>300 mg/dL) range. Results: Prevalences of abnormal SCr levels: 18% (of all men) and 5% (of all women); in the mining/subsistence farming village, 26% and 7%; banana/sugarcane, 22% and 6%; fishing, 13% and 4%; services, 0% and 1%; and coffee, 7% and 0%. Prevalences of estimated glomerular filtration rate <60 mL/min/1.73 m2: 14% (of all men) and 3% (of all women); in the listed villages, 19% and 5%, 17% and 4%, 10% and 2%, 0% and 0%, and 7% and 0%, respectively. Proteinuria, predominantly in the low range, affected 14% and 11% of all men and women without marked differences between villages. By occupation, abnormal SCr levels occurred in 31% and 24% of male and female agricultural workers at 100-300 m above sea level, but not at higher altitudes, and also was high in male artisans (43%), construction workers (15%), and miners (14%). In logistic regression models, for the banana/sugarcane and mining/subsistence farming villages, high blood pressure and age were significant predictors of abnormal SCr levels in men, and for mining/subsistence farming, age in women. Limitations: Causality is not addressed. Conclusions: In some Nicaraguan villages and population segments, men in particular show a high prevalence of decreased kidney function of unknown origin, possibly environmental or occupational. Am J Kidney Dis 55: 485-496. (C) 2010 by the National Kidney Foundation, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1589817
- author
- Torres, Cecilia ; Aragon, Aurora ; Gonzalez, Marvin ; Lopez, Indiana ; Jakobsson, Kristina LU ; Elinder, Carl-Gustaf ; Lundberg, Ingvar and Wesseling, Catharina
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- agriculture, occupation, Central America, prevalence, rate (GFR), glomerular filtration, Serum creatinine, chronic kidney disease (CKD)
- in
- American Journal of Kidney Diseases
- volume
- 55
- issue
- 3
- pages
- 485 - 496
- publisher
- Elsevier
- external identifiers
-
- wos:000275109000013
- scopus:77049094625
- pmid:20116154
- ISSN
- 1523-6838
- DOI
- 10.1053/j.ajkd.2009.12.012
- language
- English
- LU publication?
- yes
- id
- 88f3e82a-68a6-4148-b088-ea008f51a9d3 (old id 1589817)
- date added to LUP
- 2016-04-01 10:41:58
- date last changed
- 2022-04-20 05:13:10
@article{88f3e82a-68a6-4148-b088-ea008f51a9d3, abstract = {{Background: End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. Study Design: Cross-sectional survey. Setting & Participants: Total populations aged 20-60 years of 5 villages in Northwest Nicaragua: mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). Predictor or Factor: Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors. Outcomes: Serum creatinine (SCr) values greater than laboratory reference range for sex, estimated glomerular filtration rate <60 mL/min/1.73 m(2), proteinuria stratified in the low (dipstick protein excretion, 30-300 mg/dL) and high (>300 mg/dL) range. Results: Prevalences of abnormal SCr levels: 18% (of all men) and 5% (of all women); in the mining/subsistence farming village, 26% and 7%; banana/sugarcane, 22% and 6%; fishing, 13% and 4%; services, 0% and 1%; and coffee, 7% and 0%. Prevalences of estimated glomerular filtration rate <60 mL/min/1.73 m2: 14% (of all men) and 3% (of all women); in the listed villages, 19% and 5%, 17% and 4%, 10% and 2%, 0% and 0%, and 7% and 0%, respectively. Proteinuria, predominantly in the low range, affected 14% and 11% of all men and women without marked differences between villages. By occupation, abnormal SCr levels occurred in 31% and 24% of male and female agricultural workers at 100-300 m above sea level, but not at higher altitudes, and also was high in male artisans (43%), construction workers (15%), and miners (14%). In logistic regression models, for the banana/sugarcane and mining/subsistence farming villages, high blood pressure and age were significant predictors of abnormal SCr levels in men, and for mining/subsistence farming, age in women. Limitations: Causality is not addressed. Conclusions: In some Nicaraguan villages and population segments, men in particular show a high prevalence of decreased kidney function of unknown origin, possibly environmental or occupational. Am J Kidney Dis 55: 485-496. (C) 2010 by the National Kidney Foundation, Inc.}}, author = {{Torres, Cecilia and Aragon, Aurora and Gonzalez, Marvin and Lopez, Indiana and Jakobsson, Kristina and Elinder, Carl-Gustaf and Lundberg, Ingvar and Wesseling, Catharina}}, issn = {{1523-6838}}, keywords = {{agriculture; occupation; Central America; prevalence; rate (GFR); glomerular filtration; Serum creatinine; chronic kidney disease (CKD)}}, language = {{eng}}, number = {{3}}, pages = {{485--496}}, publisher = {{Elsevier}}, series = {{American Journal of Kidney Diseases}}, title = {{Decreased Kidney Function of Unknown Cause in Nicaragua: A Community-Based Survey}}, url = {{http://dx.doi.org/10.1053/j.ajkd.2009.12.012}}, doi = {{10.1053/j.ajkd.2009.12.012}}, volume = {{55}}, year = {{2010}}, }