Sex-specific cardiovascular morbidity and mortality in a cohort treated for hypertension.
(2006) In Journal of Hypertension 24(8). p.1523-1529- Abstract
- Objective Incidence of cardiovascular disease (CVD) is higher in men than in women. The aim of this study was to investigate whether the gender differential can be modified by pharmacological intervention in a population-based setting. Design and method In a prospective population-based cohort - the Malmo Diet and Cancer study - a total of 3608 hypertensives (1559 men, 2049 women), 45-73 years old, with a mean of 10 years' treatment at baseline examination, participated in the study. Information on blood pressure-lowering medication was collected in a questionnaire. Incidences of first-ever cardiac event, stroke or CVD death were followed. The mean period of follow-up was 7.4 years. Results During follow-up, 341 first-ever CVD events and... (More)
- Objective Incidence of cardiovascular disease (CVD) is higher in men than in women. The aim of this study was to investigate whether the gender differential can be modified by pharmacological intervention in a population-based setting. Design and method In a prospective population-based cohort - the Malmo Diet and Cancer study - a total of 3608 hypertensives (1559 men, 2049 women), 45-73 years old, with a mean of 10 years' treatment at baseline examination, participated in the study. Information on blood pressure-lowering medication was collected in a questionnaire. Incidences of first-ever cardiac event, stroke or CVD death were followed. The mean period of follow-up was 7.4 years. Results During follow-up, 341 first-ever CVD events and 128 CVD deaths occurred. The risk of CVD morbidity or mortality was significantly higher in hypertensive men than in hypertensive women: cardiac event [relative risk (RR) = 3.11; 95% confidence interval (CI): 2.13 - 4.54], stroke (RR U 1.50; 95% CI: 1.01 - 2.22) and CVD death (RR = 2.96; 95% CI: 1.86 - 4.20). However, the gender gap in CVD risks was reduced with advancing age. Two background factors - single household and concomitant diabetes - are apt to have an independent sex-specific impact on CVD risk. Conclusions Gender remains a strong independent predictor for CVD morbidity and mortality, irrespective of antihypertensive intervention or other risk factors. Increased clinical attention should be given to hypertensive men living alone and hypertensive women with diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/160362
- author
- Li, Cairu LU ; Engström, Gunnar LU ; Hedblad, Bo LU and Janzon, Lars LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cardiovascular risk, blood pressure-lowering treatment, gender, differential, hypertension
- in
- Journal of Hypertension
- volume
- 24
- issue
- 8
- pages
- 1523 - 1529
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000240211900011
- scopus:33746707536
- ISSN
- 1473-5598
- DOI
- 10.1097/01.hjh.0000239287.10013.e0
- language
- English
- LU publication?
- yes
- id
- 14408559-09c1-4d44-beda-73a9ed9333c4 (old id 160362)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16877954&dopt=Abstract
- date added to LUP
- 2016-04-01 15:58:37
- date last changed
- 2022-01-28 08:27:52
@article{14408559-09c1-4d44-beda-73a9ed9333c4,
abstract = {{Objective Incidence of cardiovascular disease (CVD) is higher in men than in women. The aim of this study was to investigate whether the gender differential can be modified by pharmacological intervention in a population-based setting. Design and method In a prospective population-based cohort - the Malmo Diet and Cancer study - a total of 3608 hypertensives (1559 men, 2049 women), 45-73 years old, with a mean of 10 years' treatment at baseline examination, participated in the study. Information on blood pressure-lowering medication was collected in a questionnaire. Incidences of first-ever cardiac event, stroke or CVD death were followed. The mean period of follow-up was 7.4 years. Results During follow-up, 341 first-ever CVD events and 128 CVD deaths occurred. The risk of CVD morbidity or mortality was significantly higher in hypertensive men than in hypertensive women: cardiac event [relative risk (RR) = 3.11; 95% confidence interval (CI): 2.13 - 4.54], stroke (RR U 1.50; 95% CI: 1.01 - 2.22) and CVD death (RR = 2.96; 95% CI: 1.86 - 4.20). However, the gender gap in CVD risks was reduced with advancing age. Two background factors - single household and concomitant diabetes - are apt to have an independent sex-specific impact on CVD risk. Conclusions Gender remains a strong independent predictor for CVD morbidity and mortality, irrespective of antihypertensive intervention or other risk factors. Increased clinical attention should be given to hypertensive men living alone and hypertensive women with diabetes.}},
author = {{Li, Cairu and Engström, Gunnar and Hedblad, Bo and Janzon, Lars}},
issn = {{1473-5598}},
keywords = {{cardiovascular risk; blood pressure-lowering treatment; gender; differential; hypertension}},
language = {{eng}},
number = {{8}},
pages = {{1523--1529}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Hypertension}},
title = {{Sex-specific cardiovascular morbidity and mortality in a cohort treated for hypertension.}},
url = {{http://dx.doi.org/10.1097/01.hjh.0000239287.10013.e0}},
doi = {{10.1097/01.hjh.0000239287.10013.e0}},
volume = {{24}},
year = {{2006}},
}