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Functionalised ZnO-nanorod-based selective electrochemical sensor for intracellular glucose

Asif, Muhammad H. ; Ali, Syed M. Usman ; Nur, Omer ; Willander, Magnus ; Brannmark, Cecilia ; Stralfors, Peter ; Englund, Ulrika H. ; Elinder, Fredrik and Danielsson, Bengt LU (2010) In Biosensors & Bioelectronics 25(10). p.2205-2211
Abstract
In this article, we report a functionalised ZnO-nanorod-based selective electrochemical sensor for intracellular glucose. To adjust the sensor for intracellular glucose measurements, we grew hexagonal ZnO nanorods on the tip of a silver-covered borosilicate glass capillary (0.7 mu m diameter) and coated them with the enzyme glucose oxidase. The enzyme-coated ZnO nanorods exhibited a glucose-dependent electrochemical potential difference versus an Ag/AgCl reference microelectrode. The potential difference was linear over the concentration range of interest (0.5-1000 mu M). The measured glucose concentration in human adipocytes or frog oocytes using our ZnO-nanorod sensor was consistent with values of glucose concentration reported in the... (More)
In this article, we report a functionalised ZnO-nanorod-based selective electrochemical sensor for intracellular glucose. To adjust the sensor for intracellular glucose measurements, we grew hexagonal ZnO nanorods on the tip of a silver-covered borosilicate glass capillary (0.7 mu m diameter) and coated them with the enzyme glucose oxidase. The enzyme-coated ZnO nanorods exhibited a glucose-dependent electrochemical potential difference versus an Ag/AgCl reference microelectrode. The potential difference was linear over the concentration range of interest (0.5-1000 mu M). The measured glucose concentration in human adipocytes or frog oocytes using our ZnO-nanorod sensor was consistent with values of glucose concentration reported in the literature; furthermore, the sensor was able to show that insulin increased the intracellular glucose concentration. This nanoelectrode device demonstrates a simple technique to measure intracellular glucose concentration. (C) 2010 Elsevier B.V. All rights reserved. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Intracellular glucose, ZnO nanorods, Functionalisation, sensor, Electrochemical
in
Biosensors & Bioelectronics
volume
25
issue
10
pages
2205 - 2211
publisher
Elsevier
external identifiers
  • wos:000278702600004
  • scopus:77952567384
  • pmid:20303253
ISSN
1873-4235
DOI
10.1016/j.bios.2010.02.025
language
English
LU publication?
yes
id
6909007a-d399-4578-9c55-dc19df88a99d (old id 1631580)
date added to LUP
2016-04-01 13:14:05
date last changed
2022-03-21 17:28:21
@article{6909007a-d399-4578-9c55-dc19df88a99d,
  abstract     = {{In this article, we report a functionalised ZnO-nanorod-based selective electrochemical sensor for intracellular glucose. To adjust the sensor for intracellular glucose measurements, we grew hexagonal ZnO nanorods on the tip of a silver-covered borosilicate glass capillary (0.7 mu m diameter) and coated them with the enzyme glucose oxidase. The enzyme-coated ZnO nanorods exhibited a glucose-dependent electrochemical potential difference versus an Ag/AgCl reference microelectrode. The potential difference was linear over the concentration range of interest (0.5-1000 mu M). The measured glucose concentration in human adipocytes or frog oocytes using our ZnO-nanorod sensor was consistent with values of glucose concentration reported in the literature; furthermore, the sensor was able to show that insulin increased the intracellular glucose concentration. This nanoelectrode device demonstrates a simple technique to measure intracellular glucose concentration. (C) 2010 Elsevier B.V. All rights reserved.}},
  author       = {{Asif, Muhammad H. and Ali, Syed M. Usman and Nur, Omer and Willander, Magnus and Brannmark, Cecilia and Stralfors, Peter and Englund, Ulrika H. and Elinder, Fredrik and Danielsson, Bengt}},
  issn         = {{1873-4235}},
  keywords     = {{Intracellular glucose; ZnO nanorods; Functionalisation; sensor; Electrochemical}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{2205--2211}},
  publisher    = {{Elsevier}},
  series       = {{Biosensors & Bioelectronics}},
  title        = {{Functionalised ZnO-nanorod-based selective electrochemical sensor for intracellular glucose}},
  url          = {{http://dx.doi.org/10.1016/j.bios.2010.02.025}},
  doi          = {{10.1016/j.bios.2010.02.025}},
  volume       = {{25}},
  year         = {{2010}},
}