Properties of somatosensory synaptic integration in cerebellar granule cells in vivo.
(2006) In The Journal of Neuroscience 26(45). p.11786-11797- Abstract
- In decerebrated, nonanesthetized cats, we made intracellular whole-cell recordings and extracellular cell-attached recordings from granule cells in the cerebellar C3 zone. Spontaneous EPSPs had large, relatively constant peak amplitudes, whereas IPSPs were small and did not appear to contribute substantially to synaptic integration at a short time scale. In many cases, the EPSPs of individual mossy fiber synapses appeared to be separable by their peak amplitudes. A substantial proportion of our granule cells had small receptive fields on the forelimb skin. Skin stimulation evoked explosive responses in which the constituent EPSPs were analyzed. In the rising phase of the response, our analyses indicated a participation of three to four... (More)
- In decerebrated, nonanesthetized cats, we made intracellular whole-cell recordings and extracellular cell-attached recordings from granule cells in the cerebellar C3 zone. Spontaneous EPSPs had large, relatively constant peak amplitudes, whereas IPSPs were small and did not appear to contribute substantially to synaptic integration at a short time scale. In many cases, the EPSPs of individual mossy fiber synapses appeared to be separable by their peak amplitudes. A substantial proportion of our granule cells had small receptive fields on the forelimb skin. Skin stimulation evoked explosive responses in which the constituent EPSPs were analyzed. In the rising phase of the response, our analyses indicated a participation of three to four different mossy fiber synapses, corresponding to the total number of mossy fiber afferents. The cutaneous receptive fields of the driven EPSPs overlapped, indicating an absence of convergence of mossy fibers activated from different receptive fields. Also in granule cells activated by joint movements did we find indications that different afferents were driven by the same type of input. Regardless of input type, the temporal patterns of granule cell spike activity, both spontaneous and evoked, appeared to primarily follow the activity in the presynaptic mossy fibers, although much of the nonsynchronized mossy fiber input was filtered out. In contrast to the prevailing theories of granule cell function, our results suggest a function of granule cells as signal-to-noise enhancing threshold elements, rather than as sparse coding pattern discriminators or temporal pattern generators. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/163348
- author
- Jörntell, Henrik LU and Ekerot, Carl-Fredrik LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- synaptic transmission, synaptic integration, Golgi cells, mossy fibers, granule cells, parallel fibers
- in
- The Journal of Neuroscience
- volume
- 26
- issue
- 45
- pages
- 11786 - 11797
- publisher
- Society for Neuroscience
- external identifiers
-
- wos:000241892700029
- scopus:33751098776
- ISSN
- 1529-2401
- DOI
- 10.1523/JNEUROSCI.2939-06.2006
- language
- English
- LU publication?
- yes
- id
- c312bc4a-199a-46ba-868b-b5e7114ea820 (old id 163348)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17093099&dopt=Abstract
- date added to LUP
- 2016-04-01 16:29:19
- date last changed
- 2023-10-02 20:27:21
@article{c312bc4a-199a-46ba-868b-b5e7114ea820,
abstract = {{In decerebrated, nonanesthetized cats, we made intracellular whole-cell recordings and extracellular cell-attached recordings from granule cells in the cerebellar C3 zone. Spontaneous EPSPs had large, relatively constant peak amplitudes, whereas IPSPs were small and did not appear to contribute substantially to synaptic integration at a short time scale. In many cases, the EPSPs of individual mossy fiber synapses appeared to be separable by their peak amplitudes. A substantial proportion of our granule cells had small receptive fields on the forelimb skin. Skin stimulation evoked explosive responses in which the constituent EPSPs were analyzed. In the rising phase of the response, our analyses indicated a participation of three to four different mossy fiber synapses, corresponding to the total number of mossy fiber afferents. The cutaneous receptive fields of the driven EPSPs overlapped, indicating an absence of convergence of mossy fibers activated from different receptive fields. Also in granule cells activated by joint movements did we find indications that different afferents were driven by the same type of input. Regardless of input type, the temporal patterns of granule cell spike activity, both spontaneous and evoked, appeared to primarily follow the activity in the presynaptic mossy fibers, although much of the nonsynchronized mossy fiber input was filtered out. In contrast to the prevailing theories of granule cell function, our results suggest a function of granule cells as signal-to-noise enhancing threshold elements, rather than as sparse coding pattern discriminators or temporal pattern generators.}},
author = {{Jörntell, Henrik and Ekerot, Carl-Fredrik}},
issn = {{1529-2401}},
keywords = {{synaptic transmission; synaptic integration; Golgi cells; mossy fibers; granule cells; parallel fibers}},
language = {{eng}},
number = {{45}},
pages = {{11786--11797}},
publisher = {{Society for Neuroscience}},
series = {{The Journal of Neuroscience}},
title = {{Properties of somatosensory synaptic integration in cerebellar granule cells in vivo.}},
url = {{http://dx.doi.org/10.1523/JNEUROSCI.2939-06.2006}},
doi = {{10.1523/JNEUROSCI.2939-06.2006}},
volume = {{26}},
year = {{2006}},
}