Is it possible to improve the patch-test diagnostics for isocyanates? A stability study of petrolatum preparations of diphenylmethane-4,4'-diisocyanate and polymeric diphenylmethane diisocyanate.
(2007) In Contact Dermatitis 56(1). p.27-34- Abstract
- We have previously shown that the concentration of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in commercial test preparations was so low that patch testing with the same was not reliable. The stability of 4,4'-MDI in petrolatum (pet.) was compared with pet. preparations of polymeric diphenylmethane diisocyanate (PMDI), which consists of a complex mixture of monomeric isomers and oligomers of MDI. Preparations of 4,4'-MDI and PMDI were stored under 3 different conditions, i.e. at room temperature, refrigerated and frozen. They were analysed continuously during 1 year with regard to the content of 4,4'-MDI, 3-ring oligomers and 4-ring oligomers using liquid chromatography-mass spectrometry. PMDI preparations kept frozen were stable for a... (More)
- We have previously shown that the concentration of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in commercial test preparations was so low that patch testing with the same was not reliable. The stability of 4,4'-MDI in petrolatum (pet.) was compared with pet. preparations of polymeric diphenylmethane diisocyanate (PMDI), which consists of a complex mixture of monomeric isomers and oligomers of MDI. Preparations of 4,4'-MDI and PMDI were stored under 3 different conditions, i.e. at room temperature, refrigerated and frozen. They were analysed continuously during 1 year with regard to the content of 4,4'-MDI, 3-ring oligomers and 4-ring oligomers using liquid chromatography-mass spectrometry. PMDI preparations kept frozen were stable for a year. All other preparations failed to fulfil the requirements of stability, i.e. +/- 20% of the initial concentration. Storage in a freezer prolonged the lifetime for 4,4'-MDI. The decrease in concentration for preparations kept at room temperature and refrigerated was less rapid in PMDI preparations than in 4,4'-MDI preparations. PMDI preparations are better suited for patch testing patients exposed to MDI because they are more stable and homogeneous than 4,4'-MDI preparations. They better reflect possible allergens that workers are exposed to because products used in industry contain both monomers and oligomers. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/163916
- author
- Engfeldt, Malin LU ; Zimerson, Erik LU ; Karlsson, Daniel ; Skarping, Gunnar LU ; Isaksson, Marléne LU and Bruze, Magnus LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CAS 9016-87-9, contact dermatitis, CAS 101-68-8, stability, polyurethane, polymeric MDI, PMDI, patch, test preparation, diphenylmethane-4
- in
- Contact Dermatitis
- volume
- 56
- issue
- 1
- pages
- 27 - 34
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:33845543893
- ISSN
- 0105-1873
- DOI
- 10.1111/j.1600-0536.2007.01007.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pediatrics/Urology/Gynecology/Endocrinology (013240400), Occupational and Environmental Dermatology Unit (013241310), Division of Occupational and Environmental Medicine (013078001)
- id
- 91d1f30f-e1eb-4b94-a4f6-f99637fabf42 (old id 163916)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17177706&dopt=Abstract
- date added to LUP
- 2016-04-01 12:27:07
- date last changed
- 2022-08-06 18:28:32
@article{91d1f30f-e1eb-4b94-a4f6-f99637fabf42, abstract = {{We have previously shown that the concentration of diphenylmethane-4,4'-diisocyanate (4,4'-MDI) in commercial test preparations was so low that patch testing with the same was not reliable. The stability of 4,4'-MDI in petrolatum (pet.) was compared with pet. preparations of polymeric diphenylmethane diisocyanate (PMDI), which consists of a complex mixture of monomeric isomers and oligomers of MDI. Preparations of 4,4'-MDI and PMDI were stored under 3 different conditions, i.e. at room temperature, refrigerated and frozen. They were analysed continuously during 1 year with regard to the content of 4,4'-MDI, 3-ring oligomers and 4-ring oligomers using liquid chromatography-mass spectrometry. PMDI preparations kept frozen were stable for a year. All other preparations failed to fulfil the requirements of stability, i.e. +/- 20% of the initial concentration. Storage in a freezer prolonged the lifetime for 4,4'-MDI. The decrease in concentration for preparations kept at room temperature and refrigerated was less rapid in PMDI preparations than in 4,4'-MDI preparations. PMDI preparations are better suited for patch testing patients exposed to MDI because they are more stable and homogeneous than 4,4'-MDI preparations. They better reflect possible allergens that workers are exposed to because products used in industry contain both monomers and oligomers.}}, author = {{Engfeldt, Malin and Zimerson, Erik and Karlsson, Daniel and Skarping, Gunnar and Isaksson, Marléne and Bruze, Magnus}}, issn = {{0105-1873}}, keywords = {{CAS 9016-87-9; contact dermatitis; CAS 101-68-8; stability; polyurethane; polymeric MDI; PMDI; patch; test preparation; diphenylmethane-4}}, language = {{eng}}, number = {{1}}, pages = {{27--34}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{Is it possible to improve the patch-test diagnostics for isocyanates? A stability study of petrolatum preparations of diphenylmethane-4,4'-diisocyanate and polymeric diphenylmethane diisocyanate.}}, url = {{http://dx.doi.org/10.1111/j.1600-0536.2007.01007.x}}, doi = {{10.1111/j.1600-0536.2007.01007.x}}, volume = {{56}}, year = {{2007}}, }