The clinical use of N-terminal-pro brain natriuretic peptide in elderly patients with mental illness.
(2010) In Clinical Biochemistry 43. p.1282-1286- Abstract
- BACKGROUND: Serum N-terminal-pro brain natriuretic peptide (NT-proBNP) is regarded as a marker of vascular disease and has previously been shown to exhibit an increased frequency of pathological values in elderly patients with mental illness with vascular disease compared to patients without vascular disease. Vascular disease plays an important role in cognitive impairment in elderly patients with mental illness. METHOD: We have investigated the relation between NT-proBNP, vascular disease and cognition in consecutively enrolled elderly patients with mental illness. RESULTS: NT-proBNP level is increased in patients with vascular disease compared to patients without vascular disease, and a logistic regression analysis showed that NT-proBNP... (More)
- BACKGROUND: Serum N-terminal-pro brain natriuretic peptide (NT-proBNP) is regarded as a marker of vascular disease and has previously been shown to exhibit an increased frequency of pathological values in elderly patients with mental illness with vascular disease compared to patients without vascular disease. Vascular disease plays an important role in cognitive impairment in elderly patients with mental illness. METHOD: We have investigated the relation between NT-proBNP, vascular disease and cognition in consecutively enrolled elderly patients with mental illness. RESULTS: NT-proBNP level is increased in patients with vascular disease compared to patients without vascular disease, and a logistic regression analysis showed that NT-proBNP was a significant predictor of vascular disease. However, NT-proBNP level did not predict cognition as assessed by MMSE score. NT-proBNP level also showed a highly significant relation to mortality in all patients. CONCLUSION: Determinations of NT-proBNP could be used in elderly patients with mental illness to detect patients in need of control and treatment of vascular risk factors. The levels of NT-proBNP may also provide prognostic information. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1665129
- author
- Nilsson, Karin LU ; Gustafson, Lars LU and Hultberg, Björn LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Biochemistry
- volume
- 43
- pages
- 1282 - 1286
- publisher
- Elsevier
- external identifiers
-
- wos:000283041500003
- pmid:20727348
- scopus:77957376224
- pmid:20727348
- ISSN
- 1873-2933
- DOI
- 10.1016/j.clinbiochem.2010.08.011
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Division of Clinical Chemistry and Pharmacology (013250300)
- id
- 5f34ad36-cec1-4800-95a8-56f15afd738c (old id 1665129)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20727348?dopt=Abstract
- date added to LUP
- 2016-04-04 07:06:15
- date last changed
- 2022-01-29 01:38:50
@article{5f34ad36-cec1-4800-95a8-56f15afd738c, abstract = {{BACKGROUND: Serum N-terminal-pro brain natriuretic peptide (NT-proBNP) is regarded as a marker of vascular disease and has previously been shown to exhibit an increased frequency of pathological values in elderly patients with mental illness with vascular disease compared to patients without vascular disease. Vascular disease plays an important role in cognitive impairment in elderly patients with mental illness. METHOD: We have investigated the relation between NT-proBNP, vascular disease and cognition in consecutively enrolled elderly patients with mental illness. RESULTS: NT-proBNP level is increased in patients with vascular disease compared to patients without vascular disease, and a logistic regression analysis showed that NT-proBNP was a significant predictor of vascular disease. However, NT-proBNP level did not predict cognition as assessed by MMSE score. NT-proBNP level also showed a highly significant relation to mortality in all patients. CONCLUSION: Determinations of NT-proBNP could be used in elderly patients with mental illness to detect patients in need of control and treatment of vascular risk factors. The levels of NT-proBNP may also provide prognostic information.}}, author = {{Nilsson, Karin and Gustafson, Lars and Hultberg, Björn}}, issn = {{1873-2933}}, language = {{eng}}, pages = {{1282--1286}}, publisher = {{Elsevier}}, series = {{Clinical Biochemistry}}, title = {{The clinical use of N-terminal-pro brain natriuretic peptide in elderly patients with mental illness.}}, url = {{http://dx.doi.org/10.1016/j.clinbiochem.2010.08.011}}, doi = {{10.1016/j.clinbiochem.2010.08.011}}, volume = {{43}}, year = {{2010}}, }