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Measurement and mathematical modelling of elastic and resistive lung mechanical properties studied at sinusoidal expiratory flow.

Bitzén, Ulrika LU ; Niklason, Lisbet LU ; Göransson, Ingegerd LU and Jonson, Björn LU (2010) In Clinical Physiology and Functional Imaging 30. p.439-446
Abstract
Summary Elastic pressure/volume (P(el)/V) and elastic pressure/resistance (P(el)/R) diagrams reflect parenchymal and bronchial properties, respectively. The objective was to develop a method for determination and mathematical characterization of P(el)/V and P(el)/R relationships, simultaneously studied at sinusoidal flow-modulated vital capacity expirations in a body plethysmograph. Analysis was carried out by iterative parameter estimation based on a composite mathematical model describing a three-segment P(el)/V curve and a hyperbolic P(el)/R curve. The hypothesis was tested that the sigmoid P(el)/V curve is non-symmetric. Thirty healthy subjects were studied. The hypothesis of a non-symmetric P(el)/V curve was verified. Its upper volume... (More)
Summary Elastic pressure/volume (P(el)/V) and elastic pressure/resistance (P(el)/R) diagrams reflect parenchymal and bronchial properties, respectively. The objective was to develop a method for determination and mathematical characterization of P(el)/V and P(el)/R relationships, simultaneously studied at sinusoidal flow-modulated vital capacity expirations in a body plethysmograph. Analysis was carried out by iterative parameter estimation based on a composite mathematical model describing a three-segment P(el)/V curve and a hyperbolic P(el)/R curve. The hypothesis was tested that the sigmoid P(el)/V curve is non-symmetric. Thirty healthy subjects were studied. The hypothesis of a non-symmetric P(el)/V curve was verified. Its upper volume asymptote was nearly equal to total lung capacity (TLC), indicating lung stiffness increasing at high lung volume as the main factor limiting TLC at health. The asymptotic minimal resistance of the hyperbolic P(el)/R relationship reflected lung size. A detailed description of both P(el)/V and P(el)/R relationships was simultaneously derived from sinusoidal flow-modulated vital capacity expirations. The nature of the P(el)/V curve merits the use of a non-symmetric P(el)/V model. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging
volume
30
pages
439 - 446
publisher
Wiley-Blackwell
external identifiers
  • wos:000282573200009
  • pmid:20726995
  • scopus:78649473364
  • pmid:20726995
ISSN
1475-0961
DOI
10.1111/j.1475-097X.2010.00963.x
language
English
LU publication?
yes
id
11be05ff-cac7-44cd-b44c-d5095c95f2cb (old id 1665144)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20726995?dopt=Abstract
date added to LUP
2016-04-04 07:00:29
date last changed
2025-04-04 14:01:39
@article{11be05ff-cac7-44cd-b44c-d5095c95f2cb,
  abstract     = {{Summary Elastic pressure/volume (P(el)/V) and elastic pressure/resistance (P(el)/R) diagrams reflect parenchymal and bronchial properties, respectively. The objective was to develop a method for determination and mathematical characterization of P(el)/V and P(el)/R relationships, simultaneously studied at sinusoidal flow-modulated vital capacity expirations in a body plethysmograph. Analysis was carried out by iterative parameter estimation based on a composite mathematical model describing a three-segment P(el)/V curve and a hyperbolic P(el)/R curve. The hypothesis was tested that the sigmoid P(el)/V curve is non-symmetric. Thirty healthy subjects were studied. The hypothesis of a non-symmetric P(el)/V curve was verified. Its upper volume asymptote was nearly equal to total lung capacity (TLC), indicating lung stiffness increasing at high lung volume as the main factor limiting TLC at health. The asymptotic minimal resistance of the hyperbolic P(el)/R relationship reflected lung size. A detailed description of both P(el)/V and P(el)/R relationships was simultaneously derived from sinusoidal flow-modulated vital capacity expirations. The nature of the P(el)/V curve merits the use of a non-symmetric P(el)/V model.}},
  author       = {{Bitzén, Ulrika and Niklason, Lisbet and Göransson, Ingegerd and Jonson, Björn}},
  issn         = {{1475-0961}},
  language     = {{eng}},
  pages        = {{439--446}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Clinical Physiology and Functional Imaging}},
  title        = {{Measurement and mathematical modelling of elastic and resistive lung mechanical properties studied at sinusoidal expiratory flow.}},
  url          = {{http://dx.doi.org/10.1111/j.1475-097X.2010.00963.x}},
  doi          = {{10.1111/j.1475-097X.2010.00963.x}},
  volume       = {{30}},
  year         = {{2010}},
}