Lactobacillus plantarum 299v Enhances the Concentrations of Fecal Short-Chain Fatty Acids in Patients with Recurrent Clostridium difficile-Associated Diarrhea.
(2007) In Digestive Diseases and Sciences 52. p.2082-2086- Abstract
- Our objective was to document how intake of Lactobacillus plantarum 299v affects the concentrations of fecal organic acids during and after metronidazole treatment in 19 patients with recurrent Clostridium difficile-associated diarrhea. Fecal samples were analyzed by gas-liquid chromatography. After intake of metronidazole a significant decrease in total short-chain fatty acids was seen in the placebo group (from 77.1 to 45.5 mu mol/g; P=0.028) but not in the Lactobacillus group (79.8-60.4 mu mol/g). In addition, a statistically significant difference between treatment groups was noted for butyrate (5.6-1.2 mu mol/g in the placebo group vs. 7.6-5.6 mu mol/g in the Lactobacillus group; P=0.047). At the end of the study and after cessation... (More)
- Our objective was to document how intake of Lactobacillus plantarum 299v affects the concentrations of fecal organic acids during and after metronidazole treatment in 19 patients with recurrent Clostridium difficile-associated diarrhea. Fecal samples were analyzed by gas-liquid chromatography. After intake of metronidazole a significant decrease in total short-chain fatty acids was seen in the placebo group (from 77.1 to 45.5 mu mol/g; P=0.028) but not in the Lactobacillus group (79.8-60.4 mu mol/g). In addition, a statistically significant difference between treatment groups was noted for butyrate (5.6-1.2 mu mol/g in the placebo group vs. 7.6-5.6 mu mol/g in the Lactobacillus group; P=0.047). At the end of the study and after cessation of placebo or Lactobacillus, the total short-chain fatty acids rose to the same levels as before antibiotic treatment in the placebo group. Both treatment groups showed a significant decrease in concentrations of succinate at the end of the study in comparison to the time when metronidazole intake was stopped (6.3-1.5 mu mol/g in the placebo group versus 9.3-0.9 mu mol/g in the Lactobacillus group; P=0.028). The present study of fecal samples from a clinical trial is the first to demonstrate that administration of Lactobacillus plantarum 299v reduces the negative effects of an antibiotic on colonic fermentation. The intake of this probiotic strain may thereby provide an additional benefit for patients with recurrent Clostridium difficile-associated diarrhea. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/167738
- author
- Wullt, Marlene LU ; Johansson Hagslatt, Marie-Louise ; Odenholt, Inga LU and Berggren, Anna
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- treatment, microflora, colonic, diarrhea, probiotic bacteria, Lactobacillus plantarum 299v, short-chain fatty acids, recurrent Clostridium difficile-associated
- in
- Digestive Diseases and Sciences
- volume
- 52
- pages
- 2082 - 2086
- publisher
- Springer
- external identifiers
-
- wos:000248810300010
- scopus:34547830316
- ISSN
- 1573-2568
- DOI
- 10.1007/s10620-006-9123-3
- language
- English
- LU publication?
- yes
- id
- 0e3fe9c9-f7ce-4ca7-948b-289527758392 (old id 167738)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17420953&dopt=Abstract
- date added to LUP
- 2016-04-01 11:55:53
- date last changed
- 2022-04-13 03:30:35
@article{0e3fe9c9-f7ce-4ca7-948b-289527758392,
abstract = {{Our objective was to document how intake of Lactobacillus plantarum 299v affects the concentrations of fecal organic acids during and after metronidazole treatment in 19 patients with recurrent Clostridium difficile-associated diarrhea. Fecal samples were analyzed by gas-liquid chromatography. After intake of metronidazole a significant decrease in total short-chain fatty acids was seen in the placebo group (from 77.1 to 45.5 mu mol/g; P=0.028) but not in the Lactobacillus group (79.8-60.4 mu mol/g). In addition, a statistically significant difference between treatment groups was noted for butyrate (5.6-1.2 mu mol/g in the placebo group vs. 7.6-5.6 mu mol/g in the Lactobacillus group; P=0.047). At the end of the study and after cessation of placebo or Lactobacillus, the total short-chain fatty acids rose to the same levels as before antibiotic treatment in the placebo group. Both treatment groups showed a significant decrease in concentrations of succinate at the end of the study in comparison to the time when metronidazole intake was stopped (6.3-1.5 mu mol/g in the placebo group versus 9.3-0.9 mu mol/g in the Lactobacillus group; P=0.028). The present study of fecal samples from a clinical trial is the first to demonstrate that administration of Lactobacillus plantarum 299v reduces the negative effects of an antibiotic on colonic fermentation. The intake of this probiotic strain may thereby provide an additional benefit for patients with recurrent Clostridium difficile-associated diarrhea.}},
author = {{Wullt, Marlene and Johansson Hagslatt, Marie-Louise and Odenholt, Inga and Berggren, Anna}},
issn = {{1573-2568}},
keywords = {{treatment; microflora; colonic; diarrhea; probiotic bacteria; Lactobacillus plantarum 299v; short-chain fatty acids; recurrent Clostridium difficile-associated}},
language = {{eng}},
pages = {{2082--2086}},
publisher = {{Springer}},
series = {{Digestive Diseases and Sciences}},
title = {{Lactobacillus plantarum 299v Enhances the Concentrations of Fecal Short-Chain Fatty Acids in Patients with Recurrent Clostridium difficile-Associated Diarrhea.}},
url = {{http://dx.doi.org/10.1007/s10620-006-9123-3}},
doi = {{10.1007/s10620-006-9123-3}},
volume = {{52}},
year = {{2007}},
}