Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk
(2010) In British Journal of Haematology 150(4). p.473-479- Abstract
- P>A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles (P-trend = 1 center dot 40 x 10-15), consistent with a polygenic model of disease... (More)
- P>A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles (P-trend = 1 center dot 40 x 10-15), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1678490
- author
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- chronic lymphocytic leukaemia, risk, genotype, genome wide association
- in
- British Journal of Haematology
- volume
- 150
- issue
- 4
- pages
- 473 - 479
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000280629300009
- scopus:77955129094
- pmid:20553269
- ISSN
- 0007-1048
- DOI
- 10.1111/j.1365-2141.2010.08270.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematology/Transplantation (013022014)
- id
- d4ddae80-a095-4df1-a6f1-a239634c60e8 (old id 1678490)
- date added to LUP
- 2016-04-01 10:58:34
- date last changed
- 2022-08-13 00:34:30
@article{d4ddae80-a095-4df1-a6f1-a239634c60e8, abstract = {{P>A recent genome wide association study of chronic lymphocytic leukaemia (CLL) provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden (824 cases, 850 controls). Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk increased with increasing numbers of risk alleles (P-trend = 1 center dot 40 x 10-15), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL.}}, author = {{Crowther-Swanepoel, Dalemari and Mansouri, Mahmoud and Enjuanes, Anna and Vega, Ana and Smedby, Karin E. and Ruiz-Ponte, Clara and Jurlander, Jesper and Juliusson, Gunnar and Montserrat, Emilio and Catovsky, Daniel and Campo, Elias and Carracedo, Angel and Rosenquist, Richard and Houlston, Richard S.}}, issn = {{0007-1048}}, keywords = {{chronic lymphocytic leukaemia; risk; genotype; genome wide association}}, language = {{eng}}, number = {{4}}, pages = {{473--479}}, publisher = {{Wiley-Blackwell}}, series = {{British Journal of Haematology}}, title = {{Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk}}, url = {{http://dx.doi.org/10.1111/j.1365-2141.2010.08270.x}}, doi = {{10.1111/j.1365-2141.2010.08270.x}}, volume = {{150}}, year = {{2010}}, }