Electrostatic Chameleons in Biological Systems.
(2010) In Journal of the American Chemical Society 132(49). p.17337-17339- Abstract
- Due to large equilibrium fluctuations of protons at physiological pH, the orthophosphate ion as well as the imidazole group on histidine substantially regulate their charge upon approaching charged interfaces. This implies that these-and comparable-ions function as electostatic "proximity switches" when interacting with lipid membranes, DNA, proteins, etc. Using straightforward statistical thermodynamics as well as mesoscopic computer simulations we quantify the charge regulation mechanism and argue that it is important in a range of biological as well as technical processes.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1731830
- author
- Lund, Mikael LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the American Chemical Society
- volume
- 132
- issue
- 49
- pages
- 17337 - 17339
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000285328800001
- pmid:21086991
- scopus:78650135532
- pmid:21086991
- ISSN
- 1520-5126
- DOI
- 10.1021/ja106480a
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Theoretical Chemistry (S) (011001039)
- id
- a8897a0e-2ce5-4c01-8f75-f2ceeaa3de33 (old id 1731830)
- date added to LUP
- 2016-04-01 14:52:56
- date last changed
- 2023-01-04 07:21:23
@article{a8897a0e-2ce5-4c01-8f75-f2ceeaa3de33, abstract = {{Due to large equilibrium fluctuations of protons at physiological pH, the orthophosphate ion as well as the imidazole group on histidine substantially regulate their charge upon approaching charged interfaces. This implies that these-and comparable-ions function as electostatic "proximity switches" when interacting with lipid membranes, DNA, proteins, etc. Using straightforward statistical thermodynamics as well as mesoscopic computer simulations we quantify the charge regulation mechanism and argue that it is important in a range of biological as well as technical processes.}}, author = {{Lund, Mikael}}, issn = {{1520-5126}}, language = {{eng}}, number = {{49}}, pages = {{17337--17339}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Journal of the American Chemical Society}}, title = {{Electrostatic Chameleons in Biological Systems.}}, url = {{http://dx.doi.org/10.1021/ja106480a}}, doi = {{10.1021/ja106480a}}, volume = {{132}}, year = {{2010}}, }