The prevalence and clinical characteristics of Charles Bonnet Syndrome in Danish patients with neovascular age-related macular degeneration
(2012) In Acta Ophthalmologica 90(5). p.80-476- Abstract
PURPOSE: To investigate the prevalence and clinical characteristics of the Charles Bonnet Syndrome (CBS) in a group of Danish patients with neovascular age-related macular degeneration (AMD) and to study whether CBS is associated with a specific retinal morphology.
METHODS: Three-hundred consecutive patients with neovascular AMD attending assessment consultations following variable series of ranibizumab therapy were actively asked whether they had symptoms of CBS. If they responded positively, a detailed questionnaire was orally administered to inquire into the details of the symptoms. Detailed optical coherence tomography and autofluorescence was performed. A comparison was made between retinal morphology of a randomly selected... (More)
PURPOSE: To investigate the prevalence and clinical characteristics of the Charles Bonnet Syndrome (CBS) in a group of Danish patients with neovascular age-related macular degeneration (AMD) and to study whether CBS is associated with a specific retinal morphology.
METHODS: Three-hundred consecutive patients with neovascular AMD attending assessment consultations following variable series of ranibizumab therapy were actively asked whether they had symptoms of CBS. If they responded positively, a detailed questionnaire was orally administered to inquire into the details of the symptoms. Detailed optical coherence tomography and autofluorescence was performed. A comparison was made between retinal morphology of a randomly selected equal number of patients without CBS to patients with CBS.
RESULTS: Twenty-five (8.3%) patients of 300 had hallucinations attributable to CBS. The median lesion size - measured as total area with increased autofluorescence - in the CBS group (median 14.2 mm(2)) was not significantly different from the non-CBS group (median 16.2 mm(2)); however, the patients with CBS had significantly larger areas of geographic atrophy (median 2 mm(2)) compared to patients without CBS (median 0.3 mm(2)) (p = 0.002).
CONCLUSION: CBS is not uncommon in an unselected population with neovascular AMD, and symptoms of CBS may be associated with larger areas of geographic atrophy.
(Less)
- author
- Singh, Amardeep LU and Sørensen, Torben L
- publishing date
- 2012-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Aged, 80 and over, Denmark/epidemiology, Female, Geographic Atrophy/complications, Hallucinations/diagnosis, Humans, Male, Prevalence, Surveys and Questionnaires, Syndrome, Tomography, Optical Coherence, Vision, Low/diagnosis, Visual Acuity/physiology, Wet Macular Degeneration/complications
- in
- Acta Ophthalmologica
- volume
- 90
- issue
- 5
- pages
- 5 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:21106047
- scopus:84864402205
- ISSN
- 1755-3768
- DOI
- 10.1111/j.1755-3768.2010.02051.x
- language
- English
- LU publication?
- no
- additional info
- © 2010 The Authors. Acta Ophthalmologica © 2010 Acta Ophthalmologica Scandinavica Foundation.
- id
- 17ef12b0-bb95-4bcc-a6b3-a105307db189
- date added to LUP
- 2019-05-21 10:40:10
- date last changed
- 2024-06-11 12:23:44
@article{17ef12b0-bb95-4bcc-a6b3-a105307db189,
abstract = {{<p>PURPOSE: To investigate the prevalence and clinical characteristics of the Charles Bonnet Syndrome (CBS) in a group of Danish patients with neovascular age-related macular degeneration (AMD) and to study whether CBS is associated with a specific retinal morphology.</p><p>METHODS: Three-hundred consecutive patients with neovascular AMD attending assessment consultations following variable series of ranibizumab therapy were actively asked whether they had symptoms of CBS. If they responded positively, a detailed questionnaire was orally administered to inquire into the details of the symptoms. Detailed optical coherence tomography and autofluorescence was performed. A comparison was made between retinal morphology of a randomly selected equal number of patients without CBS to patients with CBS.</p><p>RESULTS: Twenty-five (8.3%) patients of 300 had hallucinations attributable to CBS. The median lesion size - measured as total area with increased autofluorescence - in the CBS group (median 14.2 mm(2)) was not significantly different from the non-CBS group (median 16.2 mm(2)); however, the patients with CBS had significantly larger areas of geographic atrophy (median 2 mm(2)) compared to patients without CBS (median 0.3 mm(2)) (p = 0.002).</p><p>CONCLUSION: CBS is not uncommon in an unselected population with neovascular AMD, and symptoms of CBS may be associated with larger areas of geographic atrophy.</p>}},
author = {{Singh, Amardeep and Sørensen, Torben L}},
issn = {{1755-3768}},
keywords = {{Aged; Aged, 80 and over; Denmark/epidemiology; Female; Geographic Atrophy/complications; Hallucinations/diagnosis; Humans; Male; Prevalence; Surveys and Questionnaires; Syndrome; Tomography, Optical Coherence; Vision, Low/diagnosis; Visual Acuity/physiology; Wet Macular Degeneration/complications}},
language = {{eng}},
number = {{5}},
pages = {{80--476}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Ophthalmologica}},
title = {{The prevalence and clinical characteristics of Charles Bonnet Syndrome in Danish patients with neovascular age-related macular degeneration}},
url = {{http://dx.doi.org/10.1111/j.1755-3768.2010.02051.x}},
doi = {{10.1111/j.1755-3768.2010.02051.x}},
volume = {{90}},
year = {{2012}},
}