Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves
(1986) In Acta Physiologica Scandinavica 126(4). p.14-609- Abstract
The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating... (More)
The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.
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- author
- Hansson, H A ; Dahlin, L B LU ; Danielsen, Nils LU ; Fryklund, L ; Nachemson, A K ; Polleryd, P ; Rozell, Bjorn ; Skottner, Anna ; Stemme, S and Lundborg, G LU
- organization
- publishing date
- 1986-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Animals, Female, Fluorescent Antibody Technique, Insulin-Like Growth Factor I, Nerve Regeneration, Peripheral Nerves, Rats, Rats, Inbred Strains, Schwann Cells, Sciatic Nerve, Somatomedins, Time Factors, Journal Article, Research Support, Non-U.S. Gov't
- in
- Acta Physiologica Scandinavica
- volume
- 126
- issue
- 4
- pages
- 6 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0022452186
- pmid:3521205
- ISSN
- 0001-6772
- DOI
- 10.1111/j.1748-1716.1986.tb07862.x
- language
- English
- LU publication?
- yes
- id
- 186456bf-7329-4f7c-bf41-92bea3a8fd84
- date added to LUP
- 2017-10-13 14:09:34
- date last changed
- 2024-06-25 06:09:37
@article{186456bf-7329-4f7c-bf41-92bea3a8fd84, abstract = {{<p>The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.</p>}}, author = {{Hansson, H A and Dahlin, L B and Danielsen, Nils and Fryklund, L and Nachemson, A K and Polleryd, P and Rozell, Bjorn and Skottner, Anna and Stemme, S and Lundborg, G}}, issn = {{0001-6772}}, keywords = {{Animals; Female; Fluorescent Antibody Technique; Insulin-Like Growth Factor I; Nerve Regeneration; Peripheral Nerves; Rats; Rats, Inbred Strains; Schwann Cells; Sciatic Nerve; Somatomedins; Time Factors; Journal Article; Research Support, Non-U.S. Gov't}}, language = {{eng}}, number = {{4}}, pages = {{14--609}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Physiologica Scandinavica}}, title = {{Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves}}, url = {{http://dx.doi.org/10.1111/j.1748-1716.1986.tb07862.x}}, doi = {{10.1111/j.1748-1716.1986.tb07862.x}}, volume = {{126}}, year = {{1986}}, }