Cardiovascular Diseases and Hippocampal Infarcts
Rauramaa, Tuomas ; Pikkarainen, Maria ; Englund, Elisabet LU
; Ince, Paul G.
; Jellinger, Kurt
; Paetau, Anders
; Parkkinen, Laura
and Alafuzoff, Irina
(2011)
In Hippocampus
21(3).
p.281-287
- Abstract
- The prevalence of hippocampal lesions such as hippocampal infarcts have not been studied in detail even though hippocampal alterations are known to be associated with various clinical conditions such as age-related degenerative disorders and epilepsy. Methods: Here we defined the hippocampal infarcts and assessed the prevalence of this lesion in large unselected population of 1,245 subjects age ranging from 1 to 99 years (mean age 79 +/- 1 S. E. M). Furthermore, we assessed the association of these lesions with various cardio-and cerebro-vascular disorders and other neurodegenerative lesions. The prevalence of hippocampal infarct in the study population of 1,245 subjects was 12%, increasing to 13% when only those with a clinically... (More)
- The prevalence of hippocampal lesions such as hippocampal infarcts have not been studied in detail even though hippocampal alterations are known to be associated with various clinical conditions such as age-related degenerative disorders and epilepsy. Methods: Here we defined the hippocampal infarcts and assessed the prevalence of this lesion in large unselected population of 1,245 subjects age ranging from 1 to 99 years (mean age 79 +/- 1 S. E. M). Furthermore, we assessed the association of these lesions with various cardio-and cerebro-vascular disorders and other neurodegenerative lesions. The prevalence of hippocampal infarct in the study population of 1,245 subjects was 12%, increasing to 13% when only those with a clinically diagnosed cognitive impairment (n = 311) were analyzed. Large hemispheric brain infarcts were seen in 31% of the study subjects and these lesions were strongly associated with cardiovascular risk factors such as hypertension (43%), coronary disease (32%), myocardial infarct (22%), atrial fibrillation (20%), and heart failure (20%). In contrast, hippocampal infarcts displayed a significant association only with large hemispheric brain infarct, heart failure, and cardiovascular index as assessed postmortem. It is noteworthy that only widespread hippocampal infarcts were associated with clinical symptoms of cognitive impairment or epilepsy. The surprisingly low prevalence of 12% of hippocampal infarcts in aged population found here and the failure to detect an association between this lesion and various cerebro-cardio-vascular lesions is intriguing. Whether susceptibility to ischemia in line with susceptibility to neuronal degeneration in this region is influenced by still undetermined risk-factors need further investigation. Furthermore it should be noted that the size of the hippocampal tissue damage, i.e., small vs. large cystic infarcts is of significance regarding clinical alterations. (C) 2010 Wiley-Liss, Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1869294
- author
- Rauramaa, Tuomas
; Pikkarainen, Maria
; Englund, Elisabet
LU
; Ince, Paul G.
; Jellinger, Kurt
; Paetau, Anders
; Parkkinen, Laura
and Alafuzoff, Irina
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- postmortem study, histology, hippocampus, infarct, cardiovascular, disease
- in
- Hippocampus
- volume
- 21
- issue
- 3
- pages
- 281 - 287
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000288033600006
- scopus:79951938540
- pmid:20054813
- ISSN
- 1050-9631
- DOI
- 10.1002/hipo.20747
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- eccf6126-1394-4efd-8c47-4829fec77fdd (old id 1869294)
- date added to LUP
- 2016-04-01 10:22:52
- date last changed
- 2022-05-05 21:33:40
@article{eccf6126-1394-4efd-8c47-4829fec77fdd,
abstract = {{The prevalence of hippocampal lesions such as hippocampal infarcts have not been studied in detail even though hippocampal alterations are known to be associated with various clinical conditions such as age-related degenerative disorders and epilepsy. Methods: Here we defined the hippocampal infarcts and assessed the prevalence of this lesion in large unselected population of 1,245 subjects age ranging from 1 to 99 years (mean age 79 +/- 1 S. E. M). Furthermore, we assessed the association of these lesions with various cardio-and cerebro-vascular disorders and other neurodegenerative lesions. The prevalence of hippocampal infarct in the study population of 1,245 subjects was 12%, increasing to 13% when only those with a clinically diagnosed cognitive impairment (n = 311) were analyzed. Large hemispheric brain infarcts were seen in 31% of the study subjects and these lesions were strongly associated with cardiovascular risk factors such as hypertension (43%), coronary disease (32%), myocardial infarct (22%), atrial fibrillation (20%), and heart failure (20%). In contrast, hippocampal infarcts displayed a significant association only with large hemispheric brain infarct, heart failure, and cardiovascular index as assessed postmortem. It is noteworthy that only widespread hippocampal infarcts were associated with clinical symptoms of cognitive impairment or epilepsy. The surprisingly low prevalence of 12% of hippocampal infarcts in aged population found here and the failure to detect an association between this lesion and various cerebro-cardio-vascular lesions is intriguing. Whether susceptibility to ischemia in line with susceptibility to neuronal degeneration in this region is influenced by still undetermined risk-factors need further investigation. Furthermore it should be noted that the size of the hippocampal tissue damage, i.e., small vs. large cystic infarcts is of significance regarding clinical alterations. (C) 2010 Wiley-Liss, Inc.}},
author = {{Rauramaa, Tuomas and Pikkarainen, Maria and Englund, Elisabet and Ince, Paul G. and Jellinger, Kurt and Paetau, Anders and Parkkinen, Laura and Alafuzoff, Irina}},
issn = {{1050-9631}},
keywords = {{postmortem study; histology; hippocampus; infarct; cardiovascular; disease}},
language = {{eng}},
number = {{3}},
pages = {{281--287}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Hippocampus}},
title = {{Cardiovascular Diseases and Hippocampal Infarcts}},
url = {{http://dx.doi.org/10.1002/hipo.20747}},
doi = {{10.1002/hipo.20747}},
volume = {{21}},
year = {{2011}},
}