Towards a cost-effective immobilized lipase for specialty chemicals
(2011) In Journal of Molecular Catalysis B: Enzymatic 68(2). p.200-205- Abstract
- Biocatalysis has the potential to provide the chemical industry with several advantages for the production of chemicals; but the use of this technology for the production of speciality and bulk chemicals is unfortunately limited due to the high costs related to the production of the biocatalyst. We have immobilized Candida antarctica lipase B (CALB) on different resins in order to obtain a more cost-effective biocatalyst, i.e. to find the cheapest preparation per catalytic activity, for one esterification and one amidation reaction. It was found that lipase immobilized on macroporous polypropylene (Accurel MP1000) and polymethylmethacrylate (Lewatit) provided biocatalyst preparations where the cost of enzyme and carrier was significantly... (More)
- Biocatalysis has the potential to provide the chemical industry with several advantages for the production of chemicals; but the use of this technology for the production of speciality and bulk chemicals is unfortunately limited due to the high costs related to the production of the biocatalyst. We have immobilized Candida antarctica lipase B (CALB) on different resins in order to obtain a more cost-effective biocatalyst, i.e. to find the cheapest preparation per catalytic activity, for one esterification and one amidation reaction. It was found that lipase immobilized on macroporous polypropylene (Accurel MP1000) and polymethylmethacrylate (Lewatit) provided biocatalyst preparations where the cost of enzyme and carrier was significantly less than the cost of commercially available Novozym (R) 435, indicating a potential for decreased cost. Also the stability of Accurel MP1000 bound enzyme during repeated use matched that of Novozym (R) 435. Finally the in-house biocatalyst was used in a packed-bed set-up, showing an excellent stability in repeated batches at 70 degrees C. 2010 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1877971
- author
- Tufvesson, Pär LU ; Törnvall, Ulrika LU ; Carvalho, Jorge LU ; Karlsson, Annika J. and Hatti-Kaul, Rajni LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Amidation, Esterification, Batch stirred tank reactor, Packed-bed, reactor, Biocatalyst stability
- in
- Journal of Molecular Catalysis B: Enzymatic
- volume
- 68
- issue
- 2
- pages
- 200 - 205
- publisher
- Elsevier
- external identifiers
-
- wos:000286778400012
- scopus:78650517734
- ISSN
- 1873-3158
- DOI
- 10.1016/j.molcatb.2010.11.004
- language
- English
- LU publication?
- yes
- id
- 8cd03b23-8b73-473f-b4ba-058e1bb5cc67 (old id 1877971)
- date added to LUP
- 2016-04-01 10:16:48
- date last changed
- 2022-01-25 21:39:27
@article{8cd03b23-8b73-473f-b4ba-058e1bb5cc67, abstract = {{Biocatalysis has the potential to provide the chemical industry with several advantages for the production of chemicals; but the use of this technology for the production of speciality and bulk chemicals is unfortunately limited due to the high costs related to the production of the biocatalyst. We have immobilized Candida antarctica lipase B (CALB) on different resins in order to obtain a more cost-effective biocatalyst, i.e. to find the cheapest preparation per catalytic activity, for one esterification and one amidation reaction. It was found that lipase immobilized on macroporous polypropylene (Accurel MP1000) and polymethylmethacrylate (Lewatit) provided biocatalyst preparations where the cost of enzyme and carrier was significantly less than the cost of commercially available Novozym (R) 435, indicating a potential for decreased cost. Also the stability of Accurel MP1000 bound enzyme during repeated use matched that of Novozym (R) 435. Finally the in-house biocatalyst was used in a packed-bed set-up, showing an excellent stability in repeated batches at 70 degrees C. 2010 Elsevier B.V. All rights reserved.}}, author = {{Tufvesson, Pär and Törnvall, Ulrika and Carvalho, Jorge and Karlsson, Annika J. and Hatti-Kaul, Rajni}}, issn = {{1873-3158}}, keywords = {{Amidation; Esterification; Batch stirred tank reactor; Packed-bed; reactor; Biocatalyst stability}}, language = {{eng}}, number = {{2}}, pages = {{200--205}}, publisher = {{Elsevier}}, series = {{Journal of Molecular Catalysis B: Enzymatic}}, title = {{Towards a cost-effective immobilized lipase for specialty chemicals}}, url = {{http://dx.doi.org/10.1016/j.molcatb.2010.11.004}}, doi = {{10.1016/j.molcatb.2010.11.004}}, volume = {{68}}, year = {{2011}}, }