Inflammation-sensitive proteins and risk of atrial fibrillation: a population-based cohort study.
Adamsson Eryd, Samuel LU ; Smith, Gustav LU ; Melander, Olle LU
; Hedblad, Bo
LU
and Engström, Gunnar
LU
(2011)
In European Journal of Epidemiology
26.
p.449-455
- Abstract
- Low-grade inflammation has been repeatedly associated with cardiovascular diseases but the relationship with incidence of atrial fibrillation (AF) remains unclear. We explored the association between elevated plasma levels of inflammation-sensitive proteins (ISPs) and incidence of AF in a population-based cohort. Plasma levels of five ISPs (fibrinogen, haptoglobin, ceruloplasmin, α(1)-antitrypsin and orosomucoid) and two complement factors (C3 and C4) were measured in 6,031 men (mean age 46.8 years) without history of myocardial infarction, heart failure, stroke or cancer. Incidence of hospitalizations due to AF during a mean follow-up of 25 years was studied both in relation to individual inflammatory proteins and the number of elevated... (More)
- Low-grade inflammation has been repeatedly associated with cardiovascular diseases but the relationship with incidence of atrial fibrillation (AF) remains unclear. We explored the association between elevated plasma levels of inflammation-sensitive proteins (ISPs) and incidence of AF in a population-based cohort. Plasma levels of five ISPs (fibrinogen, haptoglobin, ceruloplasmin, α(1)-antitrypsin and orosomucoid) and two complement factors (C3 and C4) were measured in 6,031 men (mean age 46.8 years) without history of myocardial infarction, heart failure, stroke or cancer. Incidence of hospitalizations due to AF during a mean follow-up of 25 years was studied both in relation to individual inflammatory proteins and the number of elevated ISPs. During follow-up, 667 patients were hospitalized with a diagnosis of AF. After adjustment for potential confounding factors, the hazard ratios (HR) for AF were 1.00 (reference), 1.08 (95% CI: 0.88-1.31), 1.07 (CI: 0.84-1.36), and 1.40 (CI: 1.12-1.74), respectively, in men with none, one, two and three or more ISPs in the 4th quartile (P for trend = 0.007). Ceruloplasmin was the only individual ISP significantly associated with incidence of AF after adjustment for confounding factors (HR 1.17 per standard deviation, 95% CI: 1.08-1.26). In conclusion, a score of five ISPs was associated with long-term incidence of hospitalizations due to AF in middle-aged men. Of the individual ISPs, a significant association was observed for ceruloplasmin, a protein previously associated with copper metabolism and oxidative stress. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1883652
- author
- Adamsson Eryd, Samuel
LU
; Smith, Gustav
LU
; Melander, Olle
LU
; Hedblad, Bo
LU
and Engström, Gunnar
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Epidemiology
- volume
- 26
- pages
- 449 - 455
- publisher
- Springer
- external identifiers
-
- wos:000293164500004
- pmid:21424216
- scopus:79959762923
- pmid:21424216
- ISSN
- 1573-7284
- DOI
- 10.1007/s10654-011-9565-6
- language
- English
- LU publication?
- yes
- id
- 631b9e9b-cc3a-491f-a0fe-293714b7c74c (old id 1883652)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21424216?dopt=Abstract
- date added to LUP
- 2016-04-01 10:35:14
- date last changed
- 2024-01-06 20:20:20
@article{631b9e9b-cc3a-491f-a0fe-293714b7c74c,
abstract = {{Low-grade inflammation has been repeatedly associated with cardiovascular diseases but the relationship with incidence of atrial fibrillation (AF) remains unclear. We explored the association between elevated plasma levels of inflammation-sensitive proteins (ISPs) and incidence of AF in a population-based cohort. Plasma levels of five ISPs (fibrinogen, haptoglobin, ceruloplasmin, α(1)-antitrypsin and orosomucoid) and two complement factors (C3 and C4) were measured in 6,031 men (mean age 46.8 years) without history of myocardial infarction, heart failure, stroke or cancer. Incidence of hospitalizations due to AF during a mean follow-up of 25 years was studied both in relation to individual inflammatory proteins and the number of elevated ISPs. During follow-up, 667 patients were hospitalized with a diagnosis of AF. After adjustment for potential confounding factors, the hazard ratios (HR) for AF were 1.00 (reference), 1.08 (95% CI: 0.88-1.31), 1.07 (CI: 0.84-1.36), and 1.40 (CI: 1.12-1.74), respectively, in men with none, one, two and three or more ISPs in the 4th quartile (P for trend = 0.007). Ceruloplasmin was the only individual ISP significantly associated with incidence of AF after adjustment for confounding factors (HR 1.17 per standard deviation, 95% CI: 1.08-1.26). In conclusion, a score of five ISPs was associated with long-term incidence of hospitalizations due to AF in middle-aged men. Of the individual ISPs, a significant association was observed for ceruloplasmin, a protein previously associated with copper metabolism and oxidative stress.}},
author = {{Adamsson Eryd, Samuel and Smith, Gustav and Melander, Olle and Hedblad, Bo and Engström, Gunnar}},
issn = {{1573-7284}},
language = {{eng}},
pages = {{449--455}},
publisher = {{Springer}},
series = {{European Journal of Epidemiology}},
title = {{Inflammation-sensitive proteins and risk of atrial fibrillation: a population-based cohort study.}},
url = {{https://lup.lub.lu.se/search/files/1969533/1890964.pdf}},
doi = {{10.1007/s10654-011-9565-6}},
volume = {{26}},
year = {{2011}},
}