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The anti-angiogenic peptide anginex greatly enhances Galectin-1 binding affinity for glycoproteins

Salomonsson, Emma LU ; Thijssen, Victor L. ; Griffioen, Arjan W. ; Nilsson, Ulf J. LU and Leffler, Hakon LU (2011) In Journal of Biological Chemistry 286(16). p.13801-13804
Abstract

Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoproteins with hundred-to thousand-fold higher affinity. Anginex also interacts with galectin-2,-7,-8N, and-9N but not with galectin-3,-4, or-9C.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Biological Chemistry
volume
286
issue
16
pages
4 pages
publisher
American Society for Biochemistry and Molecular Biology
external identifiers
  • wos:000289556200002
  • pmid:21372130
  • scopus:79954601101
  • pmid:21372130
ISSN
1083-351X
DOI
10.1074/jbc.C111.229096
language
English
LU publication?
yes
id
dd31896a-adc8-42dd-8a9c-11029def289a (old id 1884385)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21372130?dopt=Abstract
date added to LUP
2016-04-04 07:57:42
date last changed
2023-02-15 16:37:41
@article{dd31896a-adc8-42dd-8a9c-11029def289a,
  abstract     = {{<p>Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a β-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be the target for anginex, a powerful anti-angiogenic peptide with anti-tumor activity. Here we show that when bound to anginex, galectin-1 binds various glycoproteins with hundred-to thousand-fold higher affinity. Anginex also interacts with galectin-2,-7,-8N, and-9N but not with galectin-3,-4, or-9C.</p>}},
  author       = {{Salomonsson, Emma and Thijssen, Victor L. and Griffioen, Arjan W. and Nilsson, Ulf J. and Leffler, Hakon}},
  issn         = {{1083-351X}},
  language     = {{eng}},
  number       = {{16}},
  pages        = {{13801--13804}},
  publisher    = {{American Society for Biochemistry and Molecular Biology}},
  series       = {{Journal of Biological Chemistry}},
  title        = {{The anti-angiogenic peptide anginex greatly enhances Galectin-1 binding affinity for glycoproteins}},
  url          = {{http://dx.doi.org/10.1074/jbc.C111.229096}},
  doi          = {{10.1074/jbc.C111.229096}},
  volume       = {{286}},
  year         = {{2011}},
}