Imaging the Tumor Antioxidant Response with [18F]FSPG PET
(2024) In Methods in molecular biology (Clifton, N.J.) 2729. p.233-249- Abstract
(4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid ([18F]FSPG) is a flourine-18 labeled glutamate analog that enables the noninvasive in vivo imaging of cellular redox status. [18F]FSPG is transported across the cell membrane by the cystine/glutamate antiporter, system xc-, whose expression is upregulated in multiple cancer types. The requirement of cystine for the biosynthesis of glutathione, a major antioxidant, connects [18F]FSPG tissue retention to the intracellular redox response via system xc- activity. We herein describe the use of [18F]FSPG positron emission tomography (PET) to image the tumor antioxidant response and highlight key methodological considerations.
Please use this url to cite or link to this publication:
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- author
- Timmermand, Oskar Vilhelmsson LU and Witney, Timothy H
- publishing date
- 2024
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Humans, Antioxidants, Cystine, Positron-Emission Tomography/methods, Neoplasms/diagnostic imaging, Glutamic Acid
- host publication
- Positron Emission Tomography
- series title
- Methods in molecular biology (Clifton, N.J.)
- editor
- Witney, Timothy H. and Shuhendler, Adam J.
- volume
- 2729
- pages
- 17 pages
- publisher
- Humana Press
- external identifiers
-
- scopus:85177728820
- pmid:38006500
- ISSN
- 1940-6029
- ISBN
- 978-1-0716-3498-1
- 978-1-0716-3499-8
- DOI
- 10.1007/978-1-0716-3499-8_14
- language
- English
- LU publication?
- no
- additional info
- © 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
- id
- 18dd3771-32f0-485d-bcb3-b522ecd1058e
- date added to LUP
- 2024-09-26 15:11:18
- date last changed
- 2024-09-27 04:01:23
@inbook{18dd3771-32f0-485d-bcb3-b522ecd1058e, abstract = {{<p>(4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid ([18F]FSPG) is a flourine-18 labeled glutamate analog that enables the noninvasive in vivo imaging of cellular redox status. [18F]FSPG is transported across the cell membrane by the cystine/glutamate antiporter, system xc-, whose expression is upregulated in multiple cancer types. The requirement of cystine for the biosynthesis of glutathione, a major antioxidant, connects [18F]FSPG tissue retention to the intracellular redox response via system xc- activity. We herein describe the use of [18F]FSPG positron emission tomography (PET) to image the tumor antioxidant response and highlight key methodological considerations.</p>}}, author = {{Timmermand, Oskar Vilhelmsson and Witney, Timothy H}}, booktitle = {{Positron Emission Tomography}}, editor = {{Witney, Timothy H. and Shuhendler, Adam J.}}, isbn = {{978-1-0716-3498-1}}, issn = {{1940-6029}}, keywords = {{Humans; Antioxidants; Cystine; Positron-Emission Tomography/methods; Neoplasms/diagnostic imaging; Glutamic Acid}}, language = {{eng}}, pages = {{233--249}}, publisher = {{Humana Press}}, series = {{Methods in molecular biology (Clifton, N.J.)}}, title = {{Imaging the Tumor Antioxidant Response with [18F]FSPG PET}}, url = {{http://dx.doi.org/10.1007/978-1-0716-3499-8_14}}, doi = {{10.1007/978-1-0716-3499-8_14}}, volume = {{2729}}, year = {{2024}}, }