Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation
(2009) 3rd International Conference on Bioinformatics and Biomedical Engineering p.2291-2294- Abstract
- Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously... (More)
- Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1917519
- author
- Wirestam, Ronnie LU ; Engvall, Christian ; Ryding, Erik ; Holtas, Stig ; Stahlberg, Freddy and Reinstrup, Peter
- organization
- publishing date
- 2009
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- magnetic resonance imaging, perfusion, cerebral blood flow, mean, transit time, hypocapnia
- host publication
- 2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11
- pages
- 2291 - 2294
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- conference name
- 3rd International Conference on Bioinformatics and Biomedical Engineering
- conference dates
- 2009-06-11 - 2009-06-16
- external identifiers
-
- wos:000286342801119
- scopus:72749090604
- language
- English
- LU publication?
- yes
- id
- 7f3c1aa7-1a65-4698-9146-6acba2c16b18 (old id 1917519)
- date added to LUP
- 2016-04-04 12:04:05
- date last changed
- 2022-01-29 22:52:36
@inproceedings{7f3c1aa7-1a65-4698-9146-6acba2c16b18, abstract = {{Cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) decreased during hyperventilation in all volunteers (average decrease 29%), and the corresponding global CBF estimates were 73 +/- 19 ml/(min 100g) during normal breathing and 52 +/- 7.9 ml/(min 100g) during hyperventilation (mean +/- SD, n=8). Furthermore, the hypocapnic conditions induced by hyperventilation resulted in a prolongation of the mean transit time (MTT) by on average 13%. The observed CBF estimates appeared to be systematically overestimated, in accordance with previously published DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.}}, author = {{Wirestam, Ronnie and Engvall, Christian and Ryding, Erik and Holtas, Stig and Stahlberg, Freddy and Reinstrup, Peter}}, booktitle = {{2009 3Rd International Conference On Bioinformatics And Biomedical Engineering, Vols 1-11}}, keywords = {{magnetic resonance imaging; perfusion; cerebral blood flow; mean; transit time; hypocapnia}}, language = {{eng}}, pages = {{2291--2294}}, publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}}, title = {{Change in Cerebral Perfusion Detected by Dynamic Susceptibility Contrast Magnetic Resonance Imaging Normal volunteers examined during normal breathing and hyperventilation}}, year = {{2009}}, }