Pneumococcal vaccination in children at risk of developing recurrent acute otitis media - a randomized study.
(2011) In Acta paediatrica 100. p.1354-1358- Abstract
- Aim: Acute otitis media (AOM) is a common childhood disease, which often becomes recurrent (rAOM). A small reduction of AOM episodes has been noted in unselected child cohorts after vaccination with heptavalent conjugate pneumococcal vaccine (PCV7). The purpose of this study was to investigate how vaccination affects young children at risk of developing rAOM. Methods: Ninety-six children with an AOM onset before six months of age, implying a high risk for rAOM, were closely monitored until the age of two years. Fortysix were vaccinated with PCV7 and 50 were not. All episodes of AOM, emergency visits and ventilation tube insertions were registered. Results: A total of 363 AOM episodes were diagnosed. The incidence was reduced by 26%... (More)
- Aim: Acute otitis media (AOM) is a common childhood disease, which often becomes recurrent (rAOM). A small reduction of AOM episodes has been noted in unselected child cohorts after vaccination with heptavalent conjugate pneumococcal vaccine (PCV7). The purpose of this study was to investigate how vaccination affects young children at risk of developing rAOM. Methods: Ninety-six children with an AOM onset before six months of age, implying a high risk for rAOM, were closely monitored until the age of two years. Fortysix were vaccinated with PCV7 and 50 were not. All episodes of AOM, emergency visits and ventilation tube insertions were registered. Results: A total of 363 AOM episodes were diagnosed. The incidence was reduced by 26% (p=0.03), the number of emergency visits due to suspected AOM by 36% (p=0.01), and the proportion of children who received ventilation tubes was halved in the vaccine group(p=0.02). Conclusions: During the first two years of life, PCV7 significantly reduced AOM episodes, emergency visits and ventilation tube insertions in children with rAOM. Pneumococcal vaccine may be a future route to reduce antibiotic use and health care consumption in otitis-prone children. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1936734
- author
- Gisselsson-Solén, Marie LU ; Melhus, Åsa and Hermansson, Ann LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta paediatrica
- volume
- 100
- pages
- 1354 - 1358
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000294900300028
- pmid:21517964
- scopus:80052838685
- pmid:21517964
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2011.02332.x
- language
- English
- LU publication?
- yes
- id
- 1a42e02b-21eb-468d-a1a0-0125149e04d8 (old id 1936734)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21517964?dopt=Abstract
- date added to LUP
- 2016-04-04 09:13:12
- date last changed
- 2022-01-29 08:49:59
@article{1a42e02b-21eb-468d-a1a0-0125149e04d8,
abstract = {{Aim: Acute otitis media (AOM) is a common childhood disease, which often becomes recurrent (rAOM). A small reduction of AOM episodes has been noted in unselected child cohorts after vaccination with heptavalent conjugate pneumococcal vaccine (PCV7). The purpose of this study was to investigate how vaccination affects young children at risk of developing rAOM. Methods: Ninety-six children with an AOM onset before six months of age, implying a high risk for rAOM, were closely monitored until the age of two years. Fortysix were vaccinated with PCV7 and 50 were not. All episodes of AOM, emergency visits and ventilation tube insertions were registered. Results: A total of 363 AOM episodes were diagnosed. The incidence was reduced by 26% (p=0.03), the number of emergency visits due to suspected AOM by 36% (p=0.01), and the proportion of children who received ventilation tubes was halved in the vaccine group(p=0.02). Conclusions: During the first two years of life, PCV7 significantly reduced AOM episodes, emergency visits and ventilation tube insertions in children with rAOM. Pneumococcal vaccine may be a future route to reduce antibiotic use and health care consumption in otitis-prone children.}},
author = {{Gisselsson-Solén, Marie and Melhus, Åsa and Hermansson, Ann}},
issn = {{1651-2227}},
language = {{eng}},
pages = {{1354--1358}},
publisher = {{Wiley-Blackwell}},
series = {{Acta paediatrica}},
title = {{Pneumococcal vaccination in children at risk of developing recurrent acute otitis media - a randomized study.}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.2011.02332.x}},
doi = {{10.1111/j.1651-2227.2011.02332.x}},
volume = {{100}},
year = {{2011}},
}