Association between plasma leptin and blood pressure in two population-based samples of children and adolescents
(2011) In Journal of Hypertension 29(6). p.1093-1100- Abstract
- Objectives In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of leptin in the association between body mass index and blood pressure. Methods To examine these aims we used a cross-sectional random sample of children and adolescents from Denmark and Norway (n=1993) who had measures of leptin, anthropometry, blood pressure and other personal and biological risk factors for raised blood pressure available. Results... (More)
- Objectives In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of leptin in the association between body mass index and blood pressure. Methods To examine these aims we used a cross-sectional random sample of children and adolescents from Denmark and Norway (n=1993) who had measures of leptin, anthropometry, blood pressure and other personal and biological risk factors for raised blood pressure available. Results Both body mass index and leptin were positively associated with blood pressure (P<0.001). The association with leptin was stronger in pre- and early-pubertal children compared to late-and post-pubertal adolescents (P<0.01 for interaction). The association between leptin and blood pressure was almost completely mediated by body mass index, whereas the association between body mass index and blood pressure was modestly mediated by leptin. Conclusion Leptin was strongly associated with blood pressure, a relationship that to a large extent was mediated by body mass index. Conversely, the association between body mass index and blood pressure was only modestly mediated by leptin. This indicates that the influence of adiposity on blood pressure is also driven by other biological risk factors beyond leptin. Such factors could include insulin, glucose, and triglycerides although residual confounding also could account for the observed relationships. J Hypertens 29:1093-1100 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1987742
- author
- Grontved, Anders ; Steene-Johannessen, Jostein ; Kynde, Iben ; Franks, Paul LU ; Helge, Jorn Wulf ; Froberg, Karsten ; Anderssen, Sigmund A. and Andersen, Lars Bo
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adiposity, blood pressure, children, leptin
- in
- Journal of Hypertension
- volume
- 29
- issue
- 6
- pages
- 1093 - 1100
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000290251500011
- pmid:21505347
- scopus:85027930595
- ISSN
- 1473-5598
- DOI
- 10.1097/HJH.0b013e328346d787
- language
- English
- LU publication?
- yes
- id
- 48cff098-5a0d-43f7-b234-4fdd9e2b5495 (old id 1987742)
- date added to LUP
- 2016-04-01 12:58:31
- date last changed
- 2024-01-09 06:25:36
@article{48cff098-5a0d-43f7-b234-4fdd9e2b5495,
abstract = {{Objectives In this study we examined the association between leptin and blood pressure in a population-based study of Danish and Norwegian children and adolescents. Because of the putative bidirectional relationship between leptin and adiposity we formally tested (i) the mediating effect of body mass index in the association between leptin and blood pressure, and (ii) the mediating effect of leptin in the association between body mass index and blood pressure. Methods To examine these aims we used a cross-sectional random sample of children and adolescents from Denmark and Norway (n=1993) who had measures of leptin, anthropometry, blood pressure and other personal and biological risk factors for raised blood pressure available. Results Both body mass index and leptin were positively associated with blood pressure (P<0.001). The association with leptin was stronger in pre- and early-pubertal children compared to late-and post-pubertal adolescents (P<0.01 for interaction). The association between leptin and blood pressure was almost completely mediated by body mass index, whereas the association between body mass index and blood pressure was modestly mediated by leptin. Conclusion Leptin was strongly associated with blood pressure, a relationship that to a large extent was mediated by body mass index. Conversely, the association between body mass index and blood pressure was only modestly mediated by leptin. This indicates that the influence of adiposity on blood pressure is also driven by other biological risk factors beyond leptin. Such factors could include insulin, glucose, and triglycerides although residual confounding also could account for the observed relationships. J Hypertens 29:1093-1100 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.}},
author = {{Grontved, Anders and Steene-Johannessen, Jostein and Kynde, Iben and Franks, Paul and Helge, Jorn Wulf and Froberg, Karsten and Anderssen, Sigmund A. and Andersen, Lars Bo}},
issn = {{1473-5598}},
keywords = {{adiposity; blood pressure; children; leptin}},
language = {{eng}},
number = {{6}},
pages = {{1093--1100}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Journal of Hypertension}},
title = {{Association between plasma leptin and blood pressure in two population-based samples of children and adolescents}},
url = {{http://dx.doi.org/10.1097/HJH.0b013e328346d787}},
doi = {{10.1097/HJH.0b013e328346d787}},
volume = {{29}},
year = {{2011}},
}