Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development
Palmer, N. and Kaldis, P. LU
(2016)
In Current Topics in Developmental Biology
120.
p.1-53
- Abstract
The preimplantation development stage of mammalian embryogenesis consists of a series of highly conserved, regulated, and predictable cell divisions. This process is essential to allow the rapid expansion and differentiation of a single-cell zygote into a multicellular blastocyst containing cells of multiple developmental lineages. This period of development, also known as the germinal stage, encompasses several important developmental transitions, which are accompanied by dramatic changes in cell cycle profiles and dynamics. These changes are driven primarily by differences in the establishment and enforcement of cell cycle checkpoints, which must be bypassed to facilitate the completion of essential cell cycle events. Much of the... (More)
The preimplantation development stage of mammalian embryogenesis consists of a series of highly conserved, regulated, and predictable cell divisions. This process is essential to allow the rapid expansion and differentiation of a single-cell zygote into a multicellular blastocyst containing cells of multiple developmental lineages. This period of development, also known as the germinal stage, encompasses several important developmental transitions, which are accompanied by dramatic changes in cell cycle profiles and dynamics. These changes are driven primarily by differences in the establishment and enforcement of cell cycle checkpoints, which must be bypassed to facilitate the completion of essential cell cycle events. Much of the current knowledge in this area has been amassed through the study of knockout models in mice. These mouse models are powerful experimental tools, which have allowed us to dissect the relative dependence of the early embryonic cell cycles on various aspects of the cell cycle machinery and highlight the extent of functional redundancy between members of the same gene family. This chapter will explore the ways in which the cell cycle machinery, their accessory proteins, and their stimuli operate during mammalian preimplantation using mouse models as a reference and how this allows for the usually well-defined stages of the cell cycle to be shaped and transformed during this unique and critical stage of development.
(Less)
- author
- Palmer, N.
and Kaldis, P.
LU
- publishing date
- 2016-01-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- keywords
- Cdk2, Cell cycle, Cyclin, Cyclin-dependent kinase, Fertility, Ovary
- host publication
- Mammalian Preimplantation Development, 2016
- series title
- Current Topics in Developmental Biology
- editor
- De Pamphilis, Melvin L.
- volume
- 120
- pages
- 1 - 53
- publisher
- Academic Press
- external identifiers
-
- pmid:27475848
- scopus:84992316549
- ISSN
- 0070-2153
- ISBN
- 9780128014288
- DOI
- 10.1016/bs.ctdb.2016.05.001
- language
- English
- LU publication?
- no
- id
- 1ddef40b-3056-4265-ab07-25d935d22957
- date added to LUP
- 2019-09-18 13:45:11
- date last changed
- 2024-04-30 21:41:01
@inbook{1ddef40b-3056-4265-ab07-25d935d22957,
abstract = {{<p>The preimplantation development stage of mammalian embryogenesis consists of a series of highly conserved, regulated, and predictable cell divisions. This process is essential to allow the rapid expansion and differentiation of a single-cell zygote into a multicellular blastocyst containing cells of multiple developmental lineages. This period of development, also known as the germinal stage, encompasses several important developmental transitions, which are accompanied by dramatic changes in cell cycle profiles and dynamics. These changes are driven primarily by differences in the establishment and enforcement of cell cycle checkpoints, which must be bypassed to facilitate the completion of essential cell cycle events. Much of the current knowledge in this area has been amassed through the study of knockout models in mice. These mouse models are powerful experimental tools, which have allowed us to dissect the relative dependence of the early embryonic cell cycles on various aspects of the cell cycle machinery and highlight the extent of functional redundancy between members of the same gene family. This chapter will explore the ways in which the cell cycle machinery, their accessory proteins, and their stimuli operate during mammalian preimplantation using mouse models as a reference and how this allows for the usually well-defined stages of the cell cycle to be shaped and transformed during this unique and critical stage of development.</p>}},
author = {{Palmer, N. and Kaldis, P.}},
booktitle = {{Mammalian Preimplantation Development, 2016}},
editor = {{De Pamphilis, Melvin L.}},
isbn = {{9780128014288}},
issn = {{0070-2153}},
keywords = {{Cdk2; Cell cycle; Cyclin; Cyclin-dependent kinase; Fertility; Ovary}},
language = {{eng}},
month = {{01}},
pages = {{1--53}},
publisher = {{Academic Press}},
series = {{Current Topics in Developmental Biology}},
title = {{Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development}},
url = {{http://dx.doi.org/10.1016/bs.ctdb.2016.05.001}},
doi = {{10.1016/bs.ctdb.2016.05.001}},
volume = {{120}},
year = {{2016}},
}