Specificity of cyclic AMP potentiation of glucose-stimulated insulin release
(1974) In Hormone Research in Paediatrics 5(4). p.227-233- Abstract
The insulin-releasing activities of cyclic and non-cyclic nucleotides were studied with isolated pancreatic islets from obese-hyperglycemic mice. Substitution of cylidine, inosine, guanosine, or uridine for the adenosine moeity of cyclic 3ʹ,5ʹ-adenosine monophosphate was associated with a total loss of insulin-releasing ability. The 5ʹ-nucleotide triphosphate derivatives of these nucleotides were all ineffective. It is suggested that cyclic AMP potentiation of glucose-stimulated insulin release in the mouse is highly specific for this nucleotide.
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https://lup.lub.lu.se/record/1f3091c3-4853-4d43-b719-d8520b64f9d6
- author
- Lernmark, Åke LU
- publishing date
- 1974-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cyclic AMP, Cyclic mononucleotides, Insulin release, Isolated islets
- in
- Hormone Research in Paediatrics
- volume
- 5
- issue
- 4
- pages
- 7 pages
- publisher
- Karger
- external identifiers
-
- scopus:0016258258
- pmid:4366458
- ISSN
- 1663-2818
- DOI
- 10.1159/000178635
- language
- English
- LU publication?
- no
- id
- 1f3091c3-4853-4d43-b719-d8520b64f9d6
- date added to LUP
- 2019-12-12 23:36:04
- date last changed
- 2024-03-13 08:16:24
@article{1f3091c3-4853-4d43-b719-d8520b64f9d6, abstract = {{<p>The insulin-releasing activities of cyclic and non-cyclic nucleotides were studied with isolated pancreatic islets from obese-hyperglycemic mice. Substitution of cylidine, inosine, guanosine, or uridine for the adenosine moeity of cyclic 3ʹ,5ʹ-adenosine monophosphate was associated with a total loss of insulin-releasing ability. The 5ʹ-nucleotide triphosphate derivatives of these nucleotides were all ineffective. It is suggested that cyclic AMP potentiation of glucose-stimulated insulin release in the mouse is highly specific for this nucleotide.</p>}}, author = {{Lernmark, Åke}}, issn = {{1663-2818}}, keywords = {{Cyclic AMP; Cyclic mononucleotides; Insulin release; Isolated islets}}, language = {{eng}}, month = {{01}}, number = {{4}}, pages = {{227--233}}, publisher = {{Karger}}, series = {{Hormone Research in Paediatrics}}, title = {{Specificity of cyclic AMP potentiation of glucose-stimulated insulin release}}, url = {{http://dx.doi.org/10.1159/000178635}}, doi = {{10.1159/000178635}}, volume = {{5}}, year = {{1974}}, }