The Impact of Pharmacokinetic Interactions with Eslicarbazepine Acetate Versus Oxcarbazepine and Carbamazepine in Clinical Practice
(2016) In Therapeutic Drug Monitoring 38(4). p.499-505- Abstract
Background: Eslicarbazepine acetate (ESL) is a new anti-epileptic drug (AED) chemically related to oxcarbazepine (OXC) and carbamazepine (CBZ) and is increasingly used in clinical practice. The purpose of the study was to investigate 2-way pharmacokinetic interactions between ESL and other AEDs as compared to OXC and CBZ. Methods: Anonymous data regarding age, gender, use of AEDs, daily doses and serum concentration measurements of ESL, OXC, CBZ and lamotrigine (LTG) and other AEDs were retrieved from 2 therapeutic drug monitoring (TDM) databases in Norway. Drugs were categorized according to their known potential for interactions. Concentration/dose (C/D) ratios were calculated. Results: Data from 1100 patients were available. The C/D... (More)
Background: Eslicarbazepine acetate (ESL) is a new anti-epileptic drug (AED) chemically related to oxcarbazepine (OXC) and carbamazepine (CBZ) and is increasingly used in clinical practice. The purpose of the study was to investigate 2-way pharmacokinetic interactions between ESL and other AEDs as compared to OXC and CBZ. Methods: Anonymous data regarding age, gender, use of AEDs, daily doses and serum concentration measurements of ESL, OXC, CBZ and lamotrigine (LTG) and other AEDs were retrieved from 2 therapeutic drug monitoring (TDM) databases in Norway. Drugs were categorized according to their known potential for interactions. Concentration/dose (C/D) ratios were calculated. Results: Data from 1100 patients were available. The C/D ratios of ESL and OXC were unchanged in combination with enzyme-inducing AEDs or valproate (VPA). The C/D ratio of CBZ decreased by 40% and 22% in combination with other enzyme-inducing AEDs or VPA, respectively, pointing to an increased clearance. ESL demonstrated no significant enzyme-inducing effect on LTG metabolism although there was a 20% and 34% decrease in the C/D ratio of LTG in combination with OXC and CBZ, respectively. Conclusions: Possible pharmacokinetic interactions have been studied for ESL as compared to OXC and CBZ. The pharmacokinetics of ESL is not affected by enzyme-inducing AEDs or VPA and does not affect the metabolism of LTG in contrast to OXC and CBZ. The study demonstrates the value of using TDM databases to explore the potential for pharmacokinetic interactions of new AEDs.
(Less)
- author
- Johannessen Landmark, Cecilie ; Svendsen, Torleiv ; Dinarevic, Jasmin ; Kufaas, Ruben F. ; Reimers, Arne LU ; Brodtkorb, Eylert ; Baftiu, Arton ; Burns, Margrete L. ; Guptill, Jeffrey and Johannessen, Svein I.
- publishing date
- 2016-08-01
- type
- Contribution to journal
- publication status
- published
- keywords
- anti-epileptic drugs, eslicarbazepine acetate, pharmacokinetic interactions, therapeutic drug monitoring (TDM)
- in
- Therapeutic Drug Monitoring
- volume
- 38
- issue
- 4
- pages
- 499 - 505
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:27414974
- scopus:84979523549
- ISSN
- 0163-4356
- DOI
- 10.1097/FTD.0000000000000306
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © Copyright 2016 Wolters Kluwer Health, Inc. All rights reserved.
- id
- 20230526-92a6-4602-af33-1c9723def134
- date added to LUP
- 2024-08-31 14:45:02
- date last changed
- 2024-09-02 12:56:42
@article{20230526-92a6-4602-af33-1c9723def134,
abstract = {{<p>Background: Eslicarbazepine acetate (ESL) is a new anti-epileptic drug (AED) chemically related to oxcarbazepine (OXC) and carbamazepine (CBZ) and is increasingly used in clinical practice. The purpose of the study was to investigate 2-way pharmacokinetic interactions between ESL and other AEDs as compared to OXC and CBZ. Methods: Anonymous data regarding age, gender, use of AEDs, daily doses and serum concentration measurements of ESL, OXC, CBZ and lamotrigine (LTG) and other AEDs were retrieved from 2 therapeutic drug monitoring (TDM) databases in Norway. Drugs were categorized according to their known potential for interactions. Concentration/dose (C/D) ratios were calculated. Results: Data from 1100 patients were available. The C/D ratios of ESL and OXC were unchanged in combination with enzyme-inducing AEDs or valproate (VPA). The C/D ratio of CBZ decreased by 40% and 22% in combination with other enzyme-inducing AEDs or VPA, respectively, pointing to an increased clearance. ESL demonstrated no significant enzyme-inducing effect on LTG metabolism although there was a 20% and 34% decrease in the C/D ratio of LTG in combination with OXC and CBZ, respectively. Conclusions: Possible pharmacokinetic interactions have been studied for ESL as compared to OXC and CBZ. The pharmacokinetics of ESL is not affected by enzyme-inducing AEDs or VPA and does not affect the metabolism of LTG in contrast to OXC and CBZ. The study demonstrates the value of using TDM databases to explore the potential for pharmacokinetic interactions of new AEDs.</p>}},
author = {{Johannessen Landmark, Cecilie and Svendsen, Torleiv and Dinarevic, Jasmin and Kufaas, Ruben F. and Reimers, Arne and Brodtkorb, Eylert and Baftiu, Arton and Burns, Margrete L. and Guptill, Jeffrey and Johannessen, Svein I.}},
issn = {{0163-4356}},
keywords = {{anti-epileptic drugs; eslicarbazepine acetate; pharmacokinetic interactions; therapeutic drug monitoring (TDM)}},
language = {{eng}},
month = {{08}},
number = {{4}},
pages = {{499--505}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Therapeutic Drug Monitoring}},
title = {{The Impact of Pharmacokinetic Interactions with Eslicarbazepine Acetate Versus Oxcarbazepine and Carbamazepine in Clinical Practice}},
url = {{http://dx.doi.org/10.1097/FTD.0000000000000306}},
doi = {{10.1097/FTD.0000000000000306}},
volume = {{38}},
year = {{2016}},
}