IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors
(2011) In Blood 118(5). p.1283-1290- Abstract
- Deficiencies in the IL-7 signaling pathway result in severe disruptions of lymphoid development in adult mice. To understand more about how IL-7 deficiency impacts early lymphoid development, we have investigated lineage restriction events within the common lymphoid progenitor (CLP) compartment in IL-7 knockout mice. This revealed that although IL-7 deficiency had a minor impact on the development of LY6D(-) multipotent CLPs, the formation of the lineage restricted LY6D(+) CLP population was dramatically reduced. This was reflected in a low-level transcription of B-lineage genes as well as in a loss of functional B-cell commitment. The few Ly6D(+) CLPs developed in the absence of IL-7 displayed increased lineage plasticity and low... (More)
- Deficiencies in the IL-7 signaling pathway result in severe disruptions of lymphoid development in adult mice. To understand more about how IL-7 deficiency impacts early lymphoid development, we have investigated lineage restriction events within the common lymphoid progenitor (CLP) compartment in IL-7 knockout mice. This revealed that although IL-7 deficiency had a minor impact on the development of LY6D(-) multipotent CLPs, the formation of the lineage restricted LY6D(+) CLP population was dramatically reduced. This was reflected in a low-level transcription of B-lineage genes as well as in a loss of functional B-cell commitment. The few Ly6D(+) CLPs developed in the absence of IL-7 displayed increased lineage plasticity and low expression of Ebf-1. Absence of Ebf-1 could be linked to increased plasticity because even though Ly6D(+) cells develop in Ebf-1-deficient mice, these cells retain both natural killer and dendritic cell potential. This reveals that IL-7 is essential for normal development of Ly6D(+) CLPs and that Ebf-1 is crucial for lineage restriction in early lymphoid progenitors. (Blood. 2011; 118(5):1283-1290) (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2071687
- author
- Tsapogas, Panagiotis ; Zandi, Sasan ; Ahsberg, Josefine ; Zetterblad, Jenny ; Welinder, Eva LU ; Jonsson, Jan Ingvar ; Månsson, Robert LU ; Qian, Hong and Sigvardsson, Mikael
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood
- volume
- 118
- issue
- 5
- pages
- 1283 - 1290
- publisher
- American Society of Hematology
- external identifiers
-
- wos:000293510000020
- scopus:80051573966
- pmid:21652681
- ISSN
- 1528-0020
- DOI
- 10.1182/blood-2011-01-332189
- language
- English
- LU publication?
- yes
- id
- 9df59362-2e1a-4968-a7e4-6d0361a5e87f (old id 2071687)
- date added to LUP
- 2016-04-01 09:55:46
- date last changed
- 2022-02-09 20:59:24
@article{9df59362-2e1a-4968-a7e4-6d0361a5e87f, abstract = {{Deficiencies in the IL-7 signaling pathway result in severe disruptions of lymphoid development in adult mice. To understand more about how IL-7 deficiency impacts early lymphoid development, we have investigated lineage restriction events within the common lymphoid progenitor (CLP) compartment in IL-7 knockout mice. This revealed that although IL-7 deficiency had a minor impact on the development of LY6D(-) multipotent CLPs, the formation of the lineage restricted LY6D(+) CLP population was dramatically reduced. This was reflected in a low-level transcription of B-lineage genes as well as in a loss of functional B-cell commitment. The few Ly6D(+) CLPs developed in the absence of IL-7 displayed increased lineage plasticity and low expression of Ebf-1. Absence of Ebf-1 could be linked to increased plasticity because even though Ly6D(+) cells develop in Ebf-1-deficient mice, these cells retain both natural killer and dendritic cell potential. This reveals that IL-7 is essential for normal development of Ly6D(+) CLPs and that Ebf-1 is crucial for lineage restriction in early lymphoid progenitors. (Blood. 2011; 118(5):1283-1290)}}, author = {{Tsapogas, Panagiotis and Zandi, Sasan and Ahsberg, Josefine and Zetterblad, Jenny and Welinder, Eva and Jonsson, Jan Ingvar and Månsson, Robert and Qian, Hong and Sigvardsson, Mikael}}, issn = {{1528-0020}}, language = {{eng}}, number = {{5}}, pages = {{1283--1290}}, publisher = {{American Society of Hematology}}, series = {{Blood}}, title = {{IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors}}, url = {{http://dx.doi.org/10.1182/blood-2011-01-332189}}, doi = {{10.1182/blood-2011-01-332189}}, volume = {{118}}, year = {{2011}}, }