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Life’s Essential 8 is inversely associated with high-sensitivity C-reactive protein

Hebib, Lana ; Herraiz-Adillo, Ángel ; Higueras-Fresnillo, Sara ; Berglind, Daniel ; Daka, Bledar ; Wennberg, Patrik ; Hagström, Emil ; Lenander, Cecilia LU ; Ahlqvist, Viktor H. and Östgren, Carl Johan , et al. (2024) In Scientific Reports 14(1).
Abstract

Life’s Essential 8 (LE8) is a score that includes modifiable risk factors for cardiovascular disease. Four health behaviors (diet, physical activity, nicotine exposure and sleep health) and four health factors (non-HDL cholesterol, blood glucose, blood pressure and body mass index) are included. These modifiable risk factors promote inflammation, and inflammation is one of the biological mechanisms of cardiovascular disease development. Thus, we examined the relationship between cardiovascular health measured by LE8 and low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) in the cross-sectional population-based Swedish CArdioPulmonary bioImage Study (SCAPIS). The study consisted of 28,010 participants between... (More)

Life’s Essential 8 (LE8) is a score that includes modifiable risk factors for cardiovascular disease. Four health behaviors (diet, physical activity, nicotine exposure and sleep health) and four health factors (non-HDL cholesterol, blood glucose, blood pressure and body mass index) are included. These modifiable risk factors promote inflammation, and inflammation is one of the biological mechanisms of cardiovascular disease development. Thus, we examined the relationship between cardiovascular health measured by LE8 and low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) in the cross-sectional population-based Swedish CArdioPulmonary bioImage Study (SCAPIS). The study consisted of 28,010 participants between 50 and 64 years (51.5% women, mean age 57.5 years). All individual LE8 components were assigned a score between 0 (unhealthy) and 100 (healthy) points, and a global score was calculated. The association between LE8 scores and high-risk hs-CRP (defined as > 3.0 mg/L) was analyzed using adjusted logistic regression with spline analyses. There was a strong, dose response and inverse association between LE8 scores and levels of hs-CRP. Thus, those with a low LE8 score (= 50.0 points) had 5.8 higher (95% confidence interval [CI] 5.2–6.4) odds ratio (OR) of having high hs-CRP as compared to those with a high LE8 score (= 80.0 points). In conclusion, our findings show strong inverse associations between LE8 scores and levels of hs-CRP.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
14
issue
1
article number
15024
publisher
Nature Publishing Group
external identifiers
  • scopus:85197267601
  • pmid:38951604
ISSN
2045-2322
DOI
10.1038/s41598-024-65977-3
language
English
LU publication?
yes
id
20d13d27-2528-4758-92a7-3c14d032b2c0
date added to LUP
2024-08-30 12:42:25
date last changed
2024-09-13 14:00:56
@article{20d13d27-2528-4758-92a7-3c14d032b2c0,
  abstract     = {{<p>Life’s Essential 8 (LE8) is a score that includes modifiable risk factors for cardiovascular disease. Four health behaviors (diet, physical activity, nicotine exposure and sleep health) and four health factors (non-HDL cholesterol, blood glucose, blood pressure and body mass index) are included. These modifiable risk factors promote inflammation, and inflammation is one of the biological mechanisms of cardiovascular disease development. Thus, we examined the relationship between cardiovascular health measured by LE8 and low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) in the cross-sectional population-based Swedish CArdioPulmonary bioImage Study (SCAPIS). The study consisted of 28,010 participants between 50 and 64 years (51.5% women, mean age 57.5 years). All individual LE8 components were assigned a score between 0 (unhealthy) and 100 (healthy) points, and a global score was calculated. The association between LE8 scores and high-risk hs-CRP (defined as &gt; 3.0 mg/L) was analyzed using adjusted logistic regression with spline analyses. There was a strong, dose response and inverse association between LE8 scores and levels of hs-CRP. Thus, those with a low LE8 score (= 50.0 points) had 5.8 higher (95% confidence interval [CI] 5.2–6.4) odds ratio (OR) of having high hs-CRP as compared to those with a high LE8 score (= 80.0 points). In conclusion, our findings show strong inverse associations between LE8 scores and levels of hs-CRP.</p>}},
  author       = {{Hebib, Lana and Herraiz-Adillo, Ángel and Higueras-Fresnillo, Sara and Berglind, Daniel and Daka, Bledar and Wennberg, Patrik and Hagström, Emil and Lenander, Cecilia and Ahlqvist, Viktor H. and Östgren, Carl Johan and Rådholm, Karin and Henriksson, Pontus}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Life’s Essential 8 is inversely associated with high-sensitivity C-reactive protein}},
  url          = {{http://dx.doi.org/10.1038/s41598-024-65977-3}},
  doi          = {{10.1038/s41598-024-65977-3}},
  volume       = {{14}},
  year         = {{2024}},
}