Immunobiology of Intestinal Eosinophils - A Dogma in the Changing?
(2011) In Journal of Innate Immunity 3. p.565-576- Abstract
- Infiltration of eosinophils into the intestinal mucosa is a typical hallmark of antiparasite immune responses and inflammatory disorders of the intestinal tract, and eosinophils are thought to contribute to these processes by release of their cytotoxic granule content. However, utilizing novel tools to study eosinophils, it has been recognized that eosinophils are constitutively present in the gastrointestinal tract. In addition, as the dogmatic antiparasite function of eosinophils has proven difficult to document experimentally, it has become increasingly clear that eosinophils are likely to have a more complex role than previously appreciated. Thus, the prevailing dogma of eosinophils merely as antiparasitic effector cells is changing.... (More)
- Infiltration of eosinophils into the intestinal mucosa is a typical hallmark of antiparasite immune responses and inflammatory disorders of the intestinal tract, and eosinophils are thought to contribute to these processes by release of their cytotoxic granule content. However, utilizing novel tools to study eosinophils, it has been recognized that eosinophils are constitutively present in the gastrointestinal tract. In addition, as the dogmatic antiparasite function of eosinophils has proven difficult to document experimentally, it has become increasingly clear that eosinophils are likely to have a more complex role than previously appreciated. Thus, the prevailing dogma of eosinophils merely as antiparasitic effector cells is changing. Instead, it has been suggested that eosinophils can contribute also to several other processes in the intestinal mucosa, e.g. local tissue homeostasis and adaptive immune responses. This review describes the current knowledge regarding the characteristics and functions of intestinal eosinophils, and the regulation of eosinophil trafficking to the intestinal mucosa during the steady state and inflammation. Finally, potential additional and new roles of intestinal eosinophils in the intestinal mucosal immune system are discussed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2150767
- author
- Svensson Frej, Marcus LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Innate Immunity
- volume
- 3
- pages
- 565 - 576
- publisher
- Karger
- external identifiers
-
- wos:000296368900004
- pmid:21860213
- scopus:80054961279
- ISSN
- 1662-811X
- DOI
- 10.1159/000328799
- language
- English
- LU publication?
- yes
- id
- d1175cfc-2bc7-4ffb-ab3a-8592656a45eb (old id 2150767)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21860213?dopt=Abstract
- date added to LUP
- 2016-04-04 07:58:59
- date last changed
- 2022-03-15 07:36:01
@article{d1175cfc-2bc7-4ffb-ab3a-8592656a45eb,
abstract = {{Infiltration of eosinophils into the intestinal mucosa is a typical hallmark of antiparasite immune responses and inflammatory disorders of the intestinal tract, and eosinophils are thought to contribute to these processes by release of their cytotoxic granule content. However, utilizing novel tools to study eosinophils, it has been recognized that eosinophils are constitutively present in the gastrointestinal tract. In addition, as the dogmatic antiparasite function of eosinophils has proven difficult to document experimentally, it has become increasingly clear that eosinophils are likely to have a more complex role than previously appreciated. Thus, the prevailing dogma of eosinophils merely as antiparasitic effector cells is changing. Instead, it has been suggested that eosinophils can contribute also to several other processes in the intestinal mucosa, e.g. local tissue homeostasis and adaptive immune responses. This review describes the current knowledge regarding the characteristics and functions of intestinal eosinophils, and the regulation of eosinophil trafficking to the intestinal mucosa during the steady state and inflammation. Finally, potential additional and new roles of intestinal eosinophils in the intestinal mucosal immune system are discussed.}},
author = {{Svensson Frej, Marcus}},
issn = {{1662-811X}},
language = {{eng}},
pages = {{565--576}},
publisher = {{Karger}},
series = {{Journal of Innate Immunity}},
title = {{Immunobiology of Intestinal Eosinophils - A Dogma in the Changing?}},
url = {{https://lup.lub.lu.se/search/files/5161636/2295988.pdf}},
doi = {{10.1159/000328799}},
volume = {{3}},
year = {{2011}},
}