Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study.
(2011) In Diabetologia 54. p.2811-2819- Abstract
- AIMS/HYPOTHESIS:
To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland.
METHODS:
Heritability estimates for type 2 diabetes adjusted for sex, age and BMI are provided for different age groups of type 2 diabetes and for 34 clinical and metabolic traits in 5,810 individuals from 942 families using a variance component model (SOLAR). In addition, family means of these traits and their distribution across families are calculated.
RESULTS:
The strongest heritability for type 2 diabetes was seen in patients with age at onset 35-60 years (h (2) = 0.69). However, including patients with onset up to 75... (More) - AIMS/HYPOTHESIS:
To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland.
METHODS:
Heritability estimates for type 2 diabetes adjusted for sex, age and BMI are provided for different age groups of type 2 diabetes and for 34 clinical and metabolic traits in 5,810 individuals from 942 families using a variance component model (SOLAR). In addition, family means of these traits and their distribution across families are calculated.
RESULTS:
The strongest heritability for type 2 diabetes was seen in patients with age at onset 35-60 years (h (2) = 0.69). However, including patients with onset up to 75 years dropped the h (2) estimates to 0.31. Among quantitative traits, the highest h (2) estimates in all individuals and in non-diabetic individuals were seen for lean body mass (h (2) = 0.53-0.65), HDL-cholesterol (0.52-0.61) and suppression of NEFA during OGTT (0.63-0.76) followed by measures of insulin secretion (insulinogenic index [IG(30)] = 0.41-0.50) and insulin action (insulin sensitivity index [ISI] = 0.37-0.40). In contrast, physical activity showed rather low heritability (0.16-0.18), whereas smoking showed strong heritability (0.57-0.59). Family means of these traits differed two- to fivefold between families belonging to the lowest and highest quartile of the trait (p < 0.00001).
CONCLUSIONS/INTERPRETATION:
To detect stronger genetic effects in type 2 diabetes, it seems reasonable to restrict inclusion of patients to those with age at onset 35-60 years. Sequencing of families with extreme quantitative traits could be an important next step in the dissection of the genetics of type 2 diabetes. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2151278
- author
- Almgren, Peter LU ; Lehtovirta, M ; Isomaa, B ; Sarelin, L ; Taskinen, M R ; Lyssenko, Valeriya LU ; Tuomi, Tiinamaija and Groop, Leif LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetologia
- volume
- 54
- pages
- 2811 - 2819
- publisher
- Springer
- external identifiers
-
- wos:000295679800010
- pmid:21826484
- scopus:80054707972
- pmid:21826484
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-011-2267-5
- language
- English
- LU publication?
- yes
- id
- 6f223dd4-6ef0-443e-bf2f-a987ccfad6b1 (old id 2151278)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21826484?dopt=Abstract
- date added to LUP
- 2016-04-04 08:21:18
- date last changed
- 2024-03-29 18:26:40
@article{6f223dd4-6ef0-443e-bf2f-a987ccfad6b1,
abstract = {{AIMS/HYPOTHESIS:<br/><br>
To study the heritability and familiality of type 2 diabetes and related quantitative traits in families from the Botnia Study in Finland.<br/><br>
<br/><br>
METHODS:<br/><br>
Heritability estimates for type 2 diabetes adjusted for sex, age and BMI are provided for different age groups of type 2 diabetes and for 34 clinical and metabolic traits in 5,810 individuals from 942 families using a variance component model (SOLAR). In addition, family means of these traits and their distribution across families are calculated.<br/><br>
<br/><br>
RESULTS:<br/><br>
The strongest heritability for type 2 diabetes was seen in patients with age at onset 35-60 years (h (2) = 0.69). However, including patients with onset up to 75 years dropped the h (2) estimates to 0.31. Among quantitative traits, the highest h (2) estimates in all individuals and in non-diabetic individuals were seen for lean body mass (h (2) = 0.53-0.65), HDL-cholesterol (0.52-0.61) and suppression of NEFA during OGTT (0.63-0.76) followed by measures of insulin secretion (insulinogenic index [IG(30)] = 0.41-0.50) and insulin action (insulin sensitivity index [ISI] = 0.37-0.40). In contrast, physical activity showed rather low heritability (0.16-0.18), whereas smoking showed strong heritability (0.57-0.59). Family means of these traits differed two- to fivefold between families belonging to the lowest and highest quartile of the trait (p < 0.00001).<br/><br>
<br/><br>
CONCLUSIONS/INTERPRETATION:<br/><br>
To detect stronger genetic effects in type 2 diabetes, it seems reasonable to restrict inclusion of patients to those with age at onset 35-60 years. Sequencing of families with extreme quantitative traits could be an important next step in the dissection of the genetics of type 2 diabetes.}},
author = {{Almgren, Peter and Lehtovirta, M and Isomaa, B and Sarelin, L and Taskinen, M R and Lyssenko, Valeriya and Tuomi, Tiinamaija and Groop, Leif}},
issn = {{1432-0428}},
language = {{eng}},
pages = {{2811--2819}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study.}},
url = {{http://dx.doi.org/10.1007/s00125-011-2267-5}},
doi = {{10.1007/s00125-011-2267-5}},
volume = {{54}},
year = {{2011}},
}