Abnormal peripheral chemokine profile in Huntington's disease.
Wild, Edward ; Magnusson-Lind, Anna LU ; Lahiri, Nayana ; Krus, Ulrika LU ; Orth, Michael J ; Tabrizi, Sarah J and Björkqvist, Maria LU
(2011)
In PLoS Currents
3.
- Abstract
- Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. Immune activation is a well-established feature of the HD brain and we have previously demonstrated a widespread, progressive innate immune response detectable in plasma throughout the course of HD. In the present work we used multiplex ELISA to quantify levels of chemokines in plasma from controls and subjects at different stages of HD. We found an altered chemokine profile tracking with disease progression, with significant elevations of five chemokines (eotaxin-3, MIP-1β, eotaxin, MCP-1 and MCP-4) while three (eotaxin-3, MIP-1β and eotaxin) showed significant linear increases across advancing disease... (More)
- Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. Immune activation is a well-established feature of the HD brain and we have previously demonstrated a widespread, progressive innate immune response detectable in plasma throughout the course of HD. In the present work we used multiplex ELISA to quantify levels of chemokines in plasma from controls and subjects at different stages of HD. We found an altered chemokine profile tracking with disease progression, with significant elevations of five chemokines (eotaxin-3, MIP-1β, eotaxin, MCP-1 and MCP-4) while three (eotaxin-3, MIP-1β and eotaxin) showed significant linear increases across advancing disease stages. We validated our results in a separate sample cohort including subjects at different stages of HD. Here we saw that chemokine levels (MCP-1 and eotaxin) correlated with clinical scores. We conclude that, like cytokines, chemokines may be linked to the pathogenesis of HD, and that immune molecules may be valuable in tracking and exploring the pathogenesis of HD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2151301
- author
- Wild, Edward
; Magnusson-Lind, Anna
LU
; Lahiri, Nayana
; Krus, Ulrika
LU
; Orth, Michael J
; Tabrizi, Sarah J
and Björkqvist, Maria
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS Currents
- volume
- 3
- article number
- RRN1231
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:21826115
- scopus:84855975733
- ISSN
- 2157-3999
- DOI
- 10.1371/currents.RRN1231
- language
- English
- LU publication?
- yes
- id
- 7c45b648-bb75-40bb-a1de-8aa59d14e5c0 (old id 2151301)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21826115?dopt=Abstract
- date added to LUP
- 2016-04-04 09:33:54
- date last changed
- 2023-09-06 01:07:22
@article{7c45b648-bb75-40bb-a1de-8aa59d14e5c0,
abstract = {{Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. Immune activation is a well-established feature of the HD brain and we have previously demonstrated a widespread, progressive innate immune response detectable in plasma throughout the course of HD. In the present work we used multiplex ELISA to quantify levels of chemokines in plasma from controls and subjects at different stages of HD. We found an altered chemokine profile tracking with disease progression, with significant elevations of five chemokines (eotaxin-3, MIP-1β, eotaxin, MCP-1 and MCP-4) while three (eotaxin-3, MIP-1β and eotaxin) showed significant linear increases across advancing disease stages. We validated our results in a separate sample cohort including subjects at different stages of HD. Here we saw that chemokine levels (MCP-1 and eotaxin) correlated with clinical scores. We conclude that, like cytokines, chemokines may be linked to the pathogenesis of HD, and that immune molecules may be valuable in tracking and exploring the pathogenesis of HD.}},
author = {{Wild, Edward and Magnusson-Lind, Anna and Lahiri, Nayana and Krus, Ulrika and Orth, Michael J and Tabrizi, Sarah J and Björkqvist, Maria}},
issn = {{2157-3999}},
language = {{eng}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS Currents}},
title = {{Abnormal peripheral chemokine profile in Huntington's disease.}},
url = {{http://dx.doi.org/10.1371/currents.RRN1231}},
doi = {{10.1371/currents.RRN1231}},
volume = {{3}},
year = {{2011}},
}