Side-effects of post-treatment biopsies in prostate cancer patients treated with endocrine therapy alone or combined with radical radiotherapy in the Scandinavian Prostate Cancer Group-7 randomized trial
(2011) In Scandinavian Journal of Urology and Nephrology 45(4). p.233-238- Abstract
- Objective. Post-treatment prostate biopsy side-effects were evaluated in patients with locally advanced prostate cancer on endocrine therapy alone or combined with radiotherapy in the Scandinavian Prostate Cancer Group-7 randomized trial. Material and methods. One-hundred and twenty patients underwent transrectalultrasound-guided biopsy, and were requested to complete a questionnaire on side-effects occurring within 7 days' follow-up. Results. The questionnaire was returned by 109 patients (91%) (endocrine therapy only 52%, combined endocrine therapy and radiotherapy 48%). Previous therapy had no significant influence on pain, urinary flow, haematuria or haematospermia. Pain at biopsy was reported in 63% (mild, 57%; moderate, 5.6%; severe,... (More)
- Objective. Post-treatment prostate biopsy side-effects were evaluated in patients with locally advanced prostate cancer on endocrine therapy alone or combined with radiotherapy in the Scandinavian Prostate Cancer Group-7 randomized trial. Material and methods. One-hundred and twenty patients underwent transrectalultrasound-guided biopsy, and were requested to complete a questionnaire on side-effects occurring within 7 days' follow-up. Results. The questionnaire was returned by 109 patients (91%) (endocrine therapy only 52%, combined endocrine therapy and radiotherapy 48%). Previous therapy had no significant influence on pain, urinary flow, haematuria or haematospermia. Pain at biopsy was reported in 63% (mild, 57%; moderate, 5.6%; severe, one patient) and pain at follow-up in 31% (mild, 27%; moderate, four patients). Haematuria (mean duration 2.2 days) was reported in 41%, and reduced urinary flow in 20% (mild, 18%; severe: four patients; no patient had urinary retention). Haematospermia was scarce. No patient reported urinary tract infection. Rectal bleeding occurred in 18% in the endocrine and 35% in the combined therapy group (p = 0.047), with a mean duration of 1.6 and 2.2 days, respectively (p = 0.031). In logistic regression analysis, a trend towards increased rectal bleeding was found in patients on combined endocrine therapy and radiotherapy (odds ratio 2.4, p = 0.050). Conclusion. Patient-reported post-treatment prostate biopsy side-effects were mild and self-limiting. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2161620
- author
- Solberg, Arne ; Widmark, Anders ; Tasdemir, Ilker ; Ahlgren, Göran LU and Angelsen, Anders
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Endocrine therapy, post-treatment biopsy, prostate cancer, radiotherapy, side-effects
- in
- Scandinavian Journal of Urology and Nephrology
- volume
- 45
- issue
- 4
- pages
- 233 - 238
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000293909300002
- scopus:80051774412
- pmid:21452932
- ISSN
- 0036-5599
- DOI
- 10.3109/00365599.2011.560577
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Urology (013243400), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- e6fe9d07-e3e4-4768-9696-e68f597db8e4 (old id 2161620)
- date added to LUP
- 2016-04-01 15:02:11
- date last changed
- 2022-01-28 03:48:34
@article{e6fe9d07-e3e4-4768-9696-e68f597db8e4,
abstract = {{Objective. Post-treatment prostate biopsy side-effects were evaluated in patients with locally advanced prostate cancer on endocrine therapy alone or combined with radiotherapy in the Scandinavian Prostate Cancer Group-7 randomized trial. Material and methods. One-hundred and twenty patients underwent transrectalultrasound-guided biopsy, and were requested to complete a questionnaire on side-effects occurring within 7 days' follow-up. Results. The questionnaire was returned by 109 patients (91%) (endocrine therapy only 52%, combined endocrine therapy and radiotherapy 48%). Previous therapy had no significant influence on pain, urinary flow, haematuria or haematospermia. Pain at biopsy was reported in 63% (mild, 57%; moderate, 5.6%; severe, one patient) and pain at follow-up in 31% (mild, 27%; moderate, four patients). Haematuria (mean duration 2.2 days) was reported in 41%, and reduced urinary flow in 20% (mild, 18%; severe: four patients; no patient had urinary retention). Haematospermia was scarce. No patient reported urinary tract infection. Rectal bleeding occurred in 18% in the endocrine and 35% in the combined therapy group (p = 0.047), with a mean duration of 1.6 and 2.2 days, respectively (p = 0.031). In logistic regression analysis, a trend towards increased rectal bleeding was found in patients on combined endocrine therapy and radiotherapy (odds ratio 2.4, p = 0.050). Conclusion. Patient-reported post-treatment prostate biopsy side-effects were mild and self-limiting.}},
author = {{Solberg, Arne and Widmark, Anders and Tasdemir, Ilker and Ahlgren, Göran and Angelsen, Anders}},
issn = {{0036-5599}},
keywords = {{Endocrine therapy; post-treatment biopsy; prostate cancer; radiotherapy; side-effects}},
language = {{eng}},
number = {{4}},
pages = {{233--238}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Urology and Nephrology}},
title = {{Side-effects of post-treatment biopsies in prostate cancer patients treated with endocrine therapy alone or combined with radical radiotherapy in the Scandinavian Prostate Cancer Group-7 randomized trial}},
url = {{http://dx.doi.org/10.3109/00365599.2011.560577}},
doi = {{10.3109/00365599.2011.560577}},
volume = {{45}},
year = {{2011}},
}