From PDE3B to the regulation of energy homeostasis.
(2011) In Current Opinion in Pharmacology 11. p.676-682- Abstract
- The incidence of obesity in the developed world is increasing at an alarming rate. Concurrent with the increase in the incidence of obesity is an increase in the incidence of type 2 diabetes. Cyclic AMP (cAMP) and cGMP are key second messengers in all cells; for example, when it comes to processes of relevance for the regulation of energy metabolism, cAMP is a key mediator in the regulation of lipolysis, glycogenolysis, gluconeogenesis and pancreatic β cell insulin secretion. PDE3B, one of several enzymes which hydrolyze cAMP and cGMP, is expressed in cells of importance for the regulation of energy homeostasis, including adipocytes, hepatocytes, hypothalamic cells and β cells. It has been shown, using PDE3 inhibitors and gene targeting... (More)
- The incidence of obesity in the developed world is increasing at an alarming rate. Concurrent with the increase in the incidence of obesity is an increase in the incidence of type 2 diabetes. Cyclic AMP (cAMP) and cGMP are key second messengers in all cells; for example, when it comes to processes of relevance for the regulation of energy metabolism, cAMP is a key mediator in the regulation of lipolysis, glycogenolysis, gluconeogenesis and pancreatic β cell insulin secretion. PDE3B, one of several enzymes which hydrolyze cAMP and cGMP, is expressed in cells of importance for the regulation of energy homeostasis, including adipocytes, hepatocytes, hypothalamic cells and β cells. It has been shown, using PDE3 inhibitors and gene targeting approaches in cells and animals, that altered levels of PDE3B result in a number of changes in the regulation of glucose and lipid metabolism and in overall energy homeostasis. This article highlights the complexity involved in the regulation of PDE3B by hormones, and in the regulation of downstream metabolic effects by PDE3B in several interacting tissues. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2200482
- author
- Degerman, Eva LU ; Ahmad, Faiyaz ; Chung, Youn Wook ; Guirguis, Emilia ; Omar, Bilal LU ; Stenson, Lena LU and Manganiello, Vincent
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Opinion in Pharmacology
- volume
- 11
- pages
- 676 - 682
- publisher
- Elsevier
- external identifiers
-
- wos:000298523300018
- pmid:22001403
- scopus:82255192444
- pmid:22001403
- ISSN
- 1471-4973
- DOI
- 10.1016/j.coph.2011.09.015
- language
- English
- LU publication?
- yes
- id
- d8a284ee-936a-45c8-938a-f73079f45a23 (old id 2200482)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22001403?dopt=Abstract
- date added to LUP
- 2016-04-04 08:25:42
- date last changed
- 2022-05-01 06:24:42
@article{d8a284ee-936a-45c8-938a-f73079f45a23, abstract = {{The incidence of obesity in the developed world is increasing at an alarming rate. Concurrent with the increase in the incidence of obesity is an increase in the incidence of type 2 diabetes. Cyclic AMP (cAMP) and cGMP are key second messengers in all cells; for example, when it comes to processes of relevance for the regulation of energy metabolism, cAMP is a key mediator in the regulation of lipolysis, glycogenolysis, gluconeogenesis and pancreatic β cell insulin secretion. PDE3B, one of several enzymes which hydrolyze cAMP and cGMP, is expressed in cells of importance for the regulation of energy homeostasis, including adipocytes, hepatocytes, hypothalamic cells and β cells. It has been shown, using PDE3 inhibitors and gene targeting approaches in cells and animals, that altered levels of PDE3B result in a number of changes in the regulation of glucose and lipid metabolism and in overall energy homeostasis. This article highlights the complexity involved in the regulation of PDE3B by hormones, and in the regulation of downstream metabolic effects by PDE3B in several interacting tissues.}}, author = {{Degerman, Eva and Ahmad, Faiyaz and Chung, Youn Wook and Guirguis, Emilia and Omar, Bilal and Stenson, Lena and Manganiello, Vincent}}, issn = {{1471-4973}}, language = {{eng}}, pages = {{676--682}}, publisher = {{Elsevier}}, series = {{Current Opinion in Pharmacology}}, title = {{From PDE3B to the regulation of energy homeostasis.}}, url = {{http://dx.doi.org/10.1016/j.coph.2011.09.015}}, doi = {{10.1016/j.coph.2011.09.015}}, volume = {{11}}, year = {{2011}}, }