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Serial single-photon emission computed tomographic and transcranial doppler measurements for evaluation of vasospasm after aneurysmal subarachnoid hemorrhage

Egge, A ; Sjoholm, H ; Waterloo, K ; Solberg, T ; Ingebrigtsen, T and Romner, Bertil LU (2005) In Neurosurgery 57(2). p.237-248
Abstract
Objective: To assess the clinical value of serial single photon-emission computed tomographic (SPECT) measurements after aneurysmal subarachnoid hemorrhage (SAH). Methods: Thirty-two patients were studied prospectively during the first 26 days after SAH with repeated SPELT measurements; clinical examinations, and transcranial Doppler recordings. Time trends were analyzed with a general linear model. A final SPECT measurement was performed after 1 year. Results: A mean of 2.6 (range, 1-5) SPECT measurements revealed a significant (P=0.001) quadratic curve consistent with initial hypoperfusion and then with hyperperfusion during the acute stage. SPELT findings were significantly associated with transcranial Doppler recordings (P=0.016) and... (More)
Objective: To assess the clinical value of serial single photon-emission computed tomographic (SPECT) measurements after aneurysmal subarachnoid hemorrhage (SAH). Methods: Thirty-two patients were studied prospectively during the first 26 days after SAH with repeated SPELT measurements; clinical examinations, and transcranial Doppler recordings. Time trends were analyzed with a general linear model. A final SPECT measurement was performed after 1 year. Results: A mean of 2.6 (range, 1-5) SPECT measurements revealed a significant (P=0.001) quadratic curve consistent with initial hypoperfusion and then with hyperperfusion during the acute stage. SPELT findings were significantly associated with transcranial Doppler recordings (P=0.016) and clinical assessments (P=0.008). Patients fulfilling clinical and transcranial Doppler criteria for vasospasm demonstrated a more pronounced relative hypoperfusionj hyperperfusion time course. A multivariate logistic regression analysis identified SPECT measurements obtained during Days 7 to 14 after the SAH as the only independent predictor (beta=0.042, P=0.02) for impaired perfusion after 1 year. Conclusion: Serial SPECT measurements after aneurysmal SAH demonstrate that regional changes in cerebral perfusion follow a nonlinear time trend, and repeated measurements are necessary. This observation, as well as the low feasibility of SPECT, restricts the clinical value of such measurements. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hemorrhage, subarachnoid, hemodynamics, single-photon emission computed tomography, vasospasm, transcranial Doppler
in
Neurosurgery
volume
57
issue
2
pages
237 - 248
publisher
Oxford University Press
external identifiers
  • wos:000231111200009
  • pmid:16094151
  • scopus:23244432516
ISSN
0148-396X
DOI
10.1227/01.NEU.0000166538.60333.D6
language
English
LU publication?
yes
id
fdb7ccd1-d032-418b-8666-cabbfa888506 (old id 224837)
alternative location
http://www.neurosurgery-online.com/pt/re/neurosurg/abstract.00006123-200508000-00005.htm;jsessionid=GT2MpV7wjNYWBwFJck9LGGFQxwBq0nqpnB8xX25nj5ThMSpW0vhn!-79285651!181195629!8091!-1
date added to LUP
2016-04-01 16:09:03
date last changed
2022-03-14 22:30:39
@article{fdb7ccd1-d032-418b-8666-cabbfa888506,
  abstract     = {{Objective: To assess the clinical value of serial single photon-emission computed tomographic (SPECT) measurements after aneurysmal subarachnoid hemorrhage (SAH). Methods: Thirty-two patients were studied prospectively during the first 26 days after SAH with repeated SPELT measurements; clinical examinations, and transcranial Doppler recordings. Time trends were analyzed with a general linear model. A final SPECT measurement was performed after 1 year. Results: A mean of 2.6 (range, 1-5) SPECT measurements revealed a significant (P=0.001) quadratic curve consistent with initial hypoperfusion and then with hyperperfusion during the acute stage. SPELT findings were significantly associated with transcranial Doppler recordings (P=0.016) and clinical assessments (P=0.008). Patients fulfilling clinical and transcranial Doppler criteria for vasospasm demonstrated a more pronounced relative hypoperfusionj hyperperfusion time course. A multivariate logistic regression analysis identified SPECT measurements obtained during Days 7 to 14 after the SAH as the only independent predictor (beta=0.042, P=0.02) for impaired perfusion after 1 year. Conclusion: Serial SPECT measurements after aneurysmal SAH demonstrate that regional changes in cerebral perfusion follow a nonlinear time trend, and repeated measurements are necessary. This observation, as well as the low feasibility of SPECT, restricts the clinical value of such measurements.}},
  author       = {{Egge, A and Sjoholm, H and Waterloo, K and Solberg, T and Ingebrigtsen, T and Romner, Bertil}},
  issn         = {{0148-396X}},
  keywords     = {{hemorrhage; subarachnoid; hemodynamics; single-photon emission computed tomography; vasospasm; transcranial Doppler}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{237--248}},
  publisher    = {{Oxford University Press}},
  series       = {{Neurosurgery}},
  title        = {{Serial single-photon emission computed tomographic and transcranial doppler measurements for evaluation of vasospasm after aneurysmal subarachnoid hemorrhage}},
  url          = {{http://dx.doi.org/10.1227/01.NEU.0000166538.60333.D6}},
  doi          = {{10.1227/01.NEU.0000166538.60333.D6}},
  volume       = {{57}},
  year         = {{2005}},
}