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Laser-induced Fluorescence In Malignant and Normal Tissue In Mice Injected With 2 Different Carotenoporphyrins

Nilsson, H ; Johansson, Jonas LU ; Svanberg, Katarina LU ; Svanberg, Sune LU ; Jori, G ; Reddi, E ; Segalla, A ; Gust, D ; Moore, A. L and Moore, T. A (1994) In British Journal of Cancer 70(5). p.873-879
Abstract
Laser-induced fluorescence (LIF) was used to characterise the localisation of an intravenously administered trimethylated carotenoporphyrin [CP(Me)(3)] and a trimethoxylated carotenoporphyrin [CP(OMe)(3)] in an intramuscularly transplanted malignant tumour (MS-2 fibrosarcoma) and healthy muscle in female Balb/c mice, 3, 24, 48 and 96 h post injection. The fluorescence was induced with a dye laser pumped by a nitrogen laser, emitting light at 425 nm. The fluorescence spectra were recorded in the region 455-760 nm using a polychromator equipped with an image-intensified CCD camera. The tumour/peritumoral muscle ratio was about 5:1 for CP(Me), and about 6:1 for CP(OMe)(3) in terms of the background-free fluorescence intensity, which peaked at... (More)
Laser-induced fluorescence (LIF) was used to characterise the localisation of an intravenously administered trimethylated carotenoporphyrin [CP(Me)(3)] and a trimethoxylated carotenoporphyrin [CP(OMe)(3)] in an intramuscularly transplanted malignant tumour (MS-2 fibrosarcoma) and healthy muscle in female Balb/c mice, 3, 24, 48 and 96 h post injection. The fluorescence was induced with a dye laser pumped by a nitrogen laser, emitting light at 425 nm. The fluorescence spectra were recorded in the region 455-760 nm using a polychromator equipped with an image-intensified CCD camera. The tumour/peritumoral muscle ratio was about 5:1 for CP(Me), and about 6:1 for CP(OMe)(3) in terms of the background-free fluorescence intensity, which peaked at about 655 nm. By including the endogenous tissue fluorescence, the contrast was further enhanced by a factor of approximately 2. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Cancer
volume
70
issue
5
pages
873 - 879
publisher
Nature Publishing Group
external identifiers
  • scopus:0028154913
ISSN
1532-1827
DOI
10.1038/bjc.1994.413
language
English
LU publication?
yes
id
f530e9ba-dc06-480d-8721-8c2cac0f8a05 (old id 2259051)
date added to LUP
2016-04-04 08:14:25
date last changed
2021-01-03 05:21:00
@article{f530e9ba-dc06-480d-8721-8c2cac0f8a05,
  abstract     = {{Laser-induced fluorescence (LIF) was used to characterise the localisation of an intravenously administered trimethylated carotenoporphyrin [CP(Me)(3)] and a trimethoxylated carotenoporphyrin [CP(OMe)(3)] in an intramuscularly transplanted malignant tumour (MS-2 fibrosarcoma) and healthy muscle in female Balb/c mice, 3, 24, 48 and 96 h post injection. The fluorescence was induced with a dye laser pumped by a nitrogen laser, emitting light at 425 nm. The fluorescence spectra were recorded in the region 455-760 nm using a polychromator equipped with an image-intensified CCD camera. The tumour/peritumoral muscle ratio was about 5:1 for CP(Me), and about 6:1 for CP(OMe)(3) in terms of the background-free fluorescence intensity, which peaked at about 655 nm. By including the endogenous tissue fluorescence, the contrast was further enhanced by a factor of approximately 2.}},
  author       = {{Nilsson, H and Johansson, Jonas and Svanberg, Katarina and Svanberg, Sune and Jori, G and Reddi, E and Segalla, A and Gust, D and Moore, A. L and Moore, T. A}},
  issn         = {{1532-1827}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{873--879}},
  publisher    = {{Nature Publishing Group}},
  series       = {{British Journal of Cancer}},
  title        = {{Laser-induced Fluorescence In Malignant and Normal Tissue In Mice Injected With 2 Different Carotenoporphyrins}},
  url          = {{https://lup.lub.lu.se/search/files/5170603/2297477.pdf}},
  doi          = {{10.1038/bjc.1994.413}},
  volume       = {{70}},
  year         = {{1994}},
}